Gpm6a - glycoprotein m6a Gene

Rattus norvegicus

Also known as M6a

Gene ID: 306439 | Gene type: protein coding

About Gpm6a

Summary

Enables Calcium Channel activity. Involved in positive regulation of filopodium assembly; regulation of synapse organization; and synapse assembly. Located in several cellular components, including filopodium; neuron projection; and neuronal cell body. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Orthologous to human GPM6A (glycoprotein M6A). [provided by Alliance of Genome Resources, Apr 2022]

Gpm6a Products(3)

mRNA	Protein	Name
NM_001394533.1	NP_001381462.1	neuronal membrane glycoprotein M6-a isoform 2
NM_001394534.1	NP_001381463.1	neuronal membrane glycoprotein M6-a isoform 3
NM_178105.3	NP_835206.1	neuronal membrane glycoprotein M6-a isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IDA IDA: Inferred from direct assay	12359212	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17548356	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	21426347	RGD
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	27793698	RGD
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	27793698	RGD
involved in synapse assembly	IDA IDA: Inferred from direct assay	19737934	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in filopodium	IDA IDA: Inferred from direct assay	16286650	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	23622064	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10447243	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	27793698	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	21426347	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	21426347	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	10447243	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	16286650	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	10447243	RGD
is active in presynaptic active zone membrane	EXP EXP: Inferred from Experiment	23622064	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	23622064	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuronal membrane glycoprotein M6-a

Gpm6a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Gpm6a	Q812E9	Oprm1	Rattus norvegicus	P33535	Pull Down	17548356
Intra	Gpm6a	Q812E9	Oprm1	Rattus norvegicus	P33535	Anti Tag CoIP	17548356
Intra	Gpm6a	Q812E9	Oprm1	Rattus norvegicus	P33535	BRET	17548356
Intra	Gpm6a	Q812E9	Oprm1	Rattus norvegicus	P33535	Y2H	17548356

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05643	GPM6A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22535	Gpm6a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS29055	Gpm6a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpm6a	NCBI	NCBI:2823

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