Oprm1 - opioid receptor, mu 1 Gene

Rattus norvegicus

Also known as MORA; Oprm; Oprrm1

Gene ID: 25601 | Gene type: protein coding

About Oprm1

Summary

Enables several functions, including G-protein beta-subunit binding activity; filamin binding activity; and morphine receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of signal transduction; and response to alkaloid. Located in several cellular components, including dendrite; focal adhesion; and perikaryon. Is active in spine apparatus. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Colocalizes with sarcolemma. Biomarker of brain ischemia and human immunodeficiency virus infectious disease. Orthologous to human OPRM1 (Opioid Receptor mu 1). [provided by Alliance of Genome Resources, Apr 2022]

Oprm1 Products(12)

mRNA	Protein	Name
NM_001038597.2	NP_001033686.1	mu-type opioid receptor isoform IA
NM_001038599.2	NP_001033688.2	mu-type opioid receptor isoform 1B2
NM_001038600.2	NP_001033689.1	mu-type opioid receptor isoform 1C1
NM_001038601.2	NP_001033690.1	mu-type opioid receptor isoform 1C2
NM_001304733.1	NP_001291662.1	mu-type opioid receptor isoform 1G1
NM_001304734.1	NP_001291663.1	mu-type opioid receptor isoform 1G2
NM_001304735.1	NP_001291664.1	mu-type opioid receptor isoform 1
NM_001304736.1	NP_001291665.1	mu-type opioid receptor isoform 1H2
NM_001304737.1	NP_001291666.1	mu-type opioid receptor isoform 1
NM_001304738.1	NP_001291667.1	mu-type opioid receptor isoform 1
NM_001304740.1	NP_001291669.1	mu-type opioid receptor isoform 1
NM_013071.2	NP_037203.1	mu-type opioid receptor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	15525342	RGD
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	9224819	RGD
enables G-protein beta-subunit binding	IPI IPI: Inferred from physical interaction	19682558	RGD
enables morphine receptor activity	IDA IDA: Inferred from direct assay	11779147	RGD
enables morphine receptor activity	IMP IMP: Inferred from mutant phenotype	9224819	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12519790	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	20214800	RGD
enables voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	1846076	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11779147	RGD
involved in acute inflammatory response to antigenic stimulus	IEP IEP: Inferred from expression pattern	19298846	RGD
involved in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IDA IDA: Inferred from direct assay	8051154	RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11779147	RGD
involved in adenylate cyclase-inhibiting opioid receptor signaling pathway	IDA IDA: Inferred from direct assay	17157995	RGD
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	15949635	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	21041644	RGD
involved in excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	18065149	RGD
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15748148	RGD
involved in negative regulation of luteinizing hormone secretion	IMP IMP: Inferred from mutant phenotype	34270714	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9572309	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	17384143	RGD
involved in positive regulation of appetite	IMP IMP: Inferred from mutant phenotype	18805404	RGD
involved in positive regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	34270714	RGD
involved in regulation of NMDA receptor activity	IMP IMP: Inferred from mutant phenotype	17976846	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	17425581	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	17156932	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	28511993	RGD
involved in response to food	IEP IEP: Inferred from expression pattern	19301417	RGD
involved in response to growth factor	IEP IEP: Inferred from expression pattern	17142830	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17553897	RGD
involved in social behavior	IMP IMP: Inferred from mutant phenotype	32388931	RGD
involved in sperm ejaculation	IDA IDA: Inferred from direct assay	31310777	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	26686371	RGD
located in dendrite	IDA IDA: Inferred from direct assay	17194545	RGD
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	16194531	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	16194531	RGD
located in focal adhesion	IDA IDA: Inferred from direct assay	17157995	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	26686371	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	17194545	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	11312309	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	11312309	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	15961389	RGD
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	26686371	RGD
is active in spine apparatus	IDA IDA: Inferred from direct assay	11312309	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mu-type opioid receptor

M-OR-1	MOR-1
MUOR1	opioid receptor B

Oprm1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Oprm1	P33535	Wls	Rattus norvegicus	Q6P689	Anti Bait CoIP	20214800
Intra	Oprm1	P33535	Gpm6a	Rattus norvegicus	Q812E9	Confocal	17548356
Intra	Oprm1	P33535	Gpm6a	Rattus norvegicus	Q812E9	Anti Tag CoIP	17548356
Intra	Oprm1	P33535	Pld2	Rattus norvegicus	P70498	Anti Tag CoIP	12519790
Intra	Oprm1	P33535	Syp	Rattus norvegicus	P07825	Y2H	17005904
Intra	Oprm1	P33535	Syp	Rattus norvegicus	P07825	Confocal	17005904
Intra	Oprm1	P33535	Syp	Rattus norvegicus	P07825	BRET	17005904

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116163	ML350		/	Unkown
HY-RS09806	OPRM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Oprm1	NCBI	NCBI:4988

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