Bcl6 - BCL6, transcription repressor Gene

About Bcl6

Summary

Predicted to enable DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of regulatory T cell differentiation; regulation of gene expression; and type 2 immune response. Predicted to act upstream of or within several processes, including hemopoiesis; negative regulation of signal transduction; and regulation of lymphocyte activation. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in nucleoplasm. Predicted to colocalize with replication fork. Human ortholog(s) of this gene implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Orthologous to human BCL6 (BCL6 transcription repressor). [provided by Alliance of Genome Resources, Apr 2022]