2. PROTAC Epigenetics Immunology/Inflammation
  3. Molecular Glues Histone Acetyltransferase BCL6
  4. TCIP3

TCIP3 is a bivalent molecular glue with with dual binding to p300/CBP and BCL6. TCIP3 redirects p300 and CBP to activate programmed cell death genes normally repressed by the oncogenic driver, BCL6. TCIP3 can be used for the study of diffuse large B cell lymphomas (DLBCLs). TCIP3 exhibits no toxicity in non-transformed tonsillar lymphocytes or fibroblasts.

For research use only. We do not sell to patients.

TCIP3 Chemical Structure

TCIP3 Chemical Structure

CAS No. : 3067681-36-8

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TCIP3 Related Antibodies

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CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

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Description

TCIP3 is a bivalent molecular glue with with dual binding to p300/CBP and BCL6. TCIP3 redirects p300 and CBP to activate programmed cell death genes normally repressed by the oncogenic driver, BCL6. TCIP3 can be used for the study of diffuse large B cell lymphomas (DLBCLs). TCIP3 exhibits no toxicity in non-transformed tonsillar lymphocytes or fibroblasts[1].

Molecular Weight

1177.74

Formula

C58H71ClF2N16O7
CAS No.
SMILES

O=C(N1CC2=C(CC1)N(C3CCN(CC3)C(CCN4CCN(CC4)C(C5CCN(CC5)C6=NC=C(C(NC7=CC(C=C(C(N8C)=O)OCC(NC)=O)=C8C(OC)=C7)=N6)Cl)=O)=O)N=C2N9C%10=C(CCC9)C=C(C%11=CN(C)N=C%11)C(C(F)F)=C%10)NC
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TCIP3 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCIP33067681-36-8TCIP 3TCIP-3Molecular GluesHistone AcetyltransferaseBCL6HATsHATB-cell lymphoma 6 proteinB-cell lymphoma 5 protein (BCL-5)Zinc finger and BTB domain-containing protein 27Zinc finger protein 51molecular gluep300/CBPDLBCLInhibitorinhibitorinhibit

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