2. Gene
  3. Cyp2e1 - cytochrome P450, family 2, subfamily e, polypeptide 1 Gene

Cyp2e1 - cytochrome P450, family 2, subfamily e, polypeptide 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cyp2e

Gene ID: 25086 | Gene type: protein coding

About Cyp2e1

Summary

Enables HSP70 protein binding activity and HSP90 protein binding activity. Involved in several processes, including response to ethanol; response to ozone; and triglyceride metabolic process. Located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Is intrinsic component of endoplasmic reticulum membrane. Used to study drug-induced hepatitis. Biomarker of several diseases, including alcohol use disorder; fatty liver disease (multiple); liver disease (multiple); middle cerebral artery infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; fatty liver disease; gastrointestinal system Cancer (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (Cytochrome P450 family 2 subfamily E member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp2e1 Products(1)

mRNA Protein Name
NM_031543.2 NP_113731.2 cytochrome P450 2E1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables Hsp70 protein binding IDA
IDA: Inferred from direct assay
19401463 RGD
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
19401463 RGD
Biological Process GO Annotation Evidence Reference Source
involved in response to 3-methylcholanthrene IEP
IEP: Inferred from expression pattern
19889059 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16337197 RGD
involved in response to ozone IEP
IEP: Inferred from expression pattern
9571988 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
21170329 RGD
involved in triglyceride metabolic process IMP
IMP: Inferred from mutant phenotype
20116195 RGD
involved in xenobiotic metabolic process IMP
IMP: Inferred from mutant phenotype
21187827 RGD
Cellular Component GO Annotation Evidence Reference Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
8809087 RGD
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
19401463 RGD
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
19401463 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 2E1

4-nitrophenol 2-hydroxylase

CYPIIE1

P450-J

P450RLM6

cytochrome P450 subfamily 2e1 (ethanol-inducible)

cytochrome P450, subfamily 2E, polypeptide 1

cytochrome P450-J

cytochrome P450RLM6

Related Agents

Approval
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N6972 Cepharanthine 99.87% Yes
HY-B0876 Fomepizole Inhibitor 99.78% Yes
HY-B0876A Fomepizole hydrochloride Inhibitor 99.85% Yes
HY-108292 Propacetamol hydrochloride 99.89% Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-129105 Clomethiazole 98.65% Phase 3
Pre-clinical Phase
Bioactive Molecules (26)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-Y0698 Thioacetamide ≥98.0% Unkown
HY-N0692 Schisandrol B 99.99% Unkown
HY-W013268 (S)-(+)-N-3-Benzylnirvanol Inhibitor 99.82% Unkown
HY-D0848 N,N'-Methylenebisacrylamide Activator 99.66% Unkown
HY-W042193 2-Piperidone 99.92% Unkown
HY-Y0110 2-Naphthol 99.91% Unkown
HY-N4110 Friedelin Inhibitor ≥99.0% Unkown
HY-116228 Cadrofloxacin Inhibitor 98.21% Unkown
HY-N1407 Polygalaxanthone III Inhibitor 99.76% Unkown
HY-W072025 CYP2E1-IN-1 / Unkown
HY-N2586 Tenuifoliside C 99.57% Unkown
HY-N8382 Chalepensin Inhibitor ≥98.0% Unkown
HY-B1462S Chlorzoxazone-d3 Modulator 98.50% Unkown
HY-W458364 1-(Isothiazol-3-yl)ethan-1-one Inhibitor / Unkown
HY-146177 CYP3A4 enzyme-IN-1 Inhibitor / Unkown
HY-19435 GYKI-47261 / Unkown
HY-19435A GYKI-47261 dihydrochloride / Unkown
HY-E70463 Human CYP2E1,High-Reductase / Unkown
HY-E70484 Human CYP2E1,High-Reductase+b5 / Unkown
HY-RS03463 CYP2E1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-Y0110S 2-Naphthol-d8 / Unkown
HY-119403 4-Phenyl-1,2,3-thiadiazole Inhibitor / Unkown
HY-B1351 Bilberry Extract / Unkown
HY-RS16890 Cyp2e1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23332 Cyp2e1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-Y0110S1 2-Naphthol-d7 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp2e1 NCBI NCBI:1571