2. Gene
  3. Glp1r - glucagon-like peptide 1 receptor Gene

Glp1r - glucagon-like peptide 1 receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Glip; RATGL1RCP

Gene ID: 25051 | Gene type: protein coding

About Glp1r

Summary

Enables G protein-coupled peptide receptor activity and peptide hormone binding activity. Involved in several processes, including cAMP-mediated signaling; learning or memory; and positive regulation of Insulin secretion. Located in plasma membrane. Is integral component of plasma membrane. Used to study hyperglycemia and hypertension. Biomarker of obesity. Orthologous to human GLP1R (glucagon like peptide 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Glp1r Products(1)

mRNA Protein Name
NM_012728.2 NP_036860.2 glucagon-like peptide 1 receptor precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled peptide receptor activity IPI
IPI: Inferred from physical interaction
8612565 RGD
enables glucagon-like peptide 1 receptor activity IDA
IDA: Inferred from direct assay
7527026 RGD
enables peptide hormone binding IDA
IDA: Inferred from direct assay
1326760 RGD
enables peptide receptor activity IDA
IDA: Inferred from direct assay
15789279 RGD
Biological Process GO Annotation Evidence Reference Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
8612565 RGD
involved in associative learning IDA
IDA: Inferred from direct assay
12925848 RGD
involved in cAMP/PKA signal transduction IMP
IMP: Inferred from mutant phenotype
10446905 RGD
involved in feeding behavior IMP
IMP: Inferred from mutant phenotype
10933308 RGD
involved in hormone secretion IDA
IDA: Inferred from direct assay
8828468 RGD
involved in insulin secretion IMP
IMP: Inferred from mutant phenotype
10362617 RGD
involved in learning or memory IMP
IMP: Inferred from mutant phenotype
12925848 RGD
involved in memory IDA
IDA: Inferred from direct assay
12925848 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
12409292 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
12925848 RGD
NOT involved in positive regulation of D-glucose import IDA
IDA: Inferred from direct assay
12093887 RGD
involved in positive regulation of blood pressure IDA
IDA: Inferred from direct assay
12093887 RGD
involved in positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
10580413 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10580413 RGD
involved in positive regulation of insulin secretion IDA
IDA: Inferred from direct assay
12093887 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11845326 RGD
involved in regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
10446905 RGD
involved in release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
15789279 RGD
involved in response to glucose IMP
IMP: Inferred from mutant phenotype
11845326 RGD
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
21046358 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glucagon-like peptide 1 receptor

GLP-1 receptor

GLP-1-R

GLP-1R

pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1

Glp1r Antibodies

Cat. No. Product Name Application Reactivity
HY-P81160 GLP-1R Antibody WB, IHC-P, IHC-F, ICC/IF, FC Human, Mouse, Rat

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114118 Semaglutide 99.84% Unkown
HY-114118A Semaglutide TFA 99.92% Unkown
HY-114118B Semaglutide acetate 99.92% Unkown
Clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Phase
HY-P3506 Retatrutide Agonist 99.96% Phase 3
HY-112185 Orforglipron Agonist 99.80% Phase 3
HY-P4146 Survodutide Agonist 99.92% Phase 3
HY-P3375 Mazdutide Agonist 99.74% Phase 3
HY-P3506A Retatrutide TFA Agonist 99.10% Phase 3
HY-P4146A Survodutide TFA Agonist 99.62% Phase 3
HY-P3375A Mazdutide TFA Agonist / Phase 3
HY-P3506B Retatrutide acetate Agonist / Phase 3
HY-125824 Danuglipron Agonist 99.85% Phase 2
HY-153865 Lotiglipron Agonist 99.68% Phase 2
HY-P3291 Dapiglutide Agonist 99.40% Phase 2
HY-P10018 Bamadutide Agonist 99.96% Phase 2
Pre-clinical Phase
Bioactive Molecules (75)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-121835 GLP-1R agonist 2 Agonist 99.94% Unkown
HY-101116 GLP-1R Antagonist 1 Antagonist 99.67% Unkown
HY-114118F Semaglutide, FITC labeled 99.83% Unkown
HY-142162 LSN3318839 Modulator 99.81% Unkown
HY-143312 V-0219 Modulator 99.86% Unkown
HY-45894 tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu Control 97.59% Unkown
HY-112185A Orforglipron hemicalcium hydrate Agonist 99.71% Unkown
HY-112679 GLP-1 receptor agonist 2 Agonist 98.70% Unkown
HY-116819 VU0453379 Modulator ≥98.0% Unkown
HY-141839 GLP-1R modulator C16 Modulator 99.60% Unkown
HY-141840 GLP-1R modulator C5 Modulator 99.60% Unkown
HY-141842 GLP-1R modulator L7-028 Modulator 98.77% Unkown
HY-143312A V-0219 hydrochloride Modulator 99.65% Unkown
HY-116819A VU0453379 hydrochloride Modulator ≥99.0% Unkown
HY-148212 GLP-1R agonist 17 Agonist 99.82% Unkown
HY-144035 GLP-1R agonist 4 Agonist 98.26% Unkown
HY-143312E (S)-V-0219 hydrochloride Modulator 99.71% Unkown
HY-144034 GLP-1R agonist 3 Agonist 99.15% Unkown
HY-147625 GLP-1R agonist 12 Agonist 95.06% Unkown
HY-P10302A GLP-1R/GIPR agonist-1 (soduim) Agonist 96.55% Unkown
HY-P10019 Pegsebrenatide Agonist 95.32% Unkown
HY-143312D (R)-V-0219 hydrochloride Modulator 99.37% Unkown
HY-147623 GLP-1R agonist 10 Agonist 98.99% Unkown
HY-153193 LSN3160440 Modulator / Unkown
HY-163996 DD202-114 Agonist 98.47% Unkown
HY-108795B [Gly8]-GLP-1(7-37) acetate Agonist / Unkown
HY-145632 Pemvidutide Agonist / Unkown
HY-147622 GLP-1R agonist 9 Agonist / Unkown
HY-P10302 GLP-1R/GIPR agonist-1 Agonist / Unkown
HY-P10716 Exendin-P5 Activator 96.70% Unkown
HY-114118S3 Semaglutide-13C6,15N TFA 96.04% Unkown
HY-138996 GLP-1 receptor agonist 8 Agonist / Unkown
HY-172811 DA-302168S Agonist / Unkown
HY-120828 Albenatide Agonist / Unkown
HY-129657 GLP-1 receptor agonist 4 Agonist / Unkown
HY-143312B (R)-V-0219 Modulator / Unkown
HY-143312C (S)-V-0219 Modulator / Unkown
HY-144033 GLP-1R agonist 1 Agonist / Unkown
HY-144133 GLP-1R agonist 5 Agonist / Unkown
HY-144134 GLP-1R agonist 6 Agonist / Unkown
HY-144135 GLP-1R agonist 7 Agonist / Unkown
HY-144136 GLP-1R agonist 8 Agonist / Unkown
HY-145632A Pemvidutide TFA Antagonist 98.07% Unkown
HY-147626 GLP-1R agonist 13 Agonist / Unkown
HY-147627 GLP-1R agonist 14 Agonist / Unkown
HY-147628 GLP-1R agonist 15 Agonist / Unkown
HY-147629 GLP-1R agonist 16 Agonist / Unkown
HY-160031 GLP-1R agonist 19 Agonist / Unkown
HY-161915 GLP-1R agonist 23 Agonist / Unkown
HY-162306 GLP-1R agonist 18 Agonist / Unkown
HY-162435 GLP-1R agonist 20 Agonist / Unkown
HY-162436 GLP-1R agonist 21 Agonist / Unkown
HY-162437 GLP-1R agonist 22 Agonist / Unkown
HY-162979 GLP-1R agonist 25 Agonist / Unkown
HY-168481 GLP-1R agonist 27 Agonist / Unkown
HY-172410 GLP-1R agonist 28 Agonist / Unkown
HY-172673 GLP-1R agonist 31 Agonist / Unkown
HY-172836S GLP-1 receptor agonist 17-d3 Agonist / Unkown
HY-173479 GLP-1R agonist 30 Agonist / Unkown
HY-P0165B Taspoglutide acetate Agonist / Unkown
HY-P0264A Exendin(9-39) amide acetate Antagonist / Unkown
HY-P10337 OXM-7 Agonist / Unkown
HY-P10842 d-GLP-2 E33A Agonist / Unkown
HY-P3539 Exendin-4 (3-39) / Unkown
HY-P3542 Des His1, Glu8 Exendin-4 Antagonist / Unkown
HY-P4386 (Asp28)-Exenatide Agonist / Unkown
HY-P5161 FC382K10W15 Agonist / Unkown
HY-P5161A FC382K10W15 TFA Agonist / Unkown
HY-RS05490 GLP1R Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-125824A Danuglipron tromethamine Agonist / Unkown
HY-142162A (S,R)-LSN3318839 Control / Unkown
HY-168585 GLP-1R agonist 26 Agonist / Unkown
HY-172411 GLP-1R agonist 29 Agonist / Unkown
HY-RS16631 Glp1r Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23066 Glp1r Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990013 Gulgafafusp alfa Inhibitor / Unkown
HY-P990967 Sonefpeglutide / Unkown
HY-P991099 Anti-GLP1R Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glp1r NCBI NCBI:2740
Mus musculus Glp1r NCBI NCBI:14652