Ppp3cb - protein phosphatase 3 catalytic subunit beta Gene

Rattus norvegicus

Also known as Calna2

Gene ID: 24675 | Gene type: protein coding

About Ppp3cb

Summary

Enables calcium-dependent protein serine/threonine Phosphatase activity and Calmodulin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of Insulin secretion involved in cellular response to glucose stimulus; and response to amphetamine. Located in plasma membrane. Part of protein-containing complex. Is active in synapse. Biomarker of schizophrenia. Human ortholog(s) of this gene implicated in aortic valve stenosis. Orthologous to human PPP3CB (protein Phosphatase 3 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Ppp3cb Products(1)

mRNA	Protein	Name
NM_017042.2	NP_058738.1	serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	12135494	RGD
enables calmodulin binding	IDA IDA: Inferred from direct assay	12135494	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15120593	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	12135494	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in muscle cell cellular homeostasis	IEP IEP: Inferred from expression pattern	11997253	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	11978799	RGD
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	12135494	RGD
involved in regulation of insulin secretion	IDA IDA: Inferred from direct assay	11978799	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	11954050	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11978799	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16306226	RGD
is active in synapse	IDA IDA: Inferred from direct assay	1313851	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

CAM-PRP catalytic subunit	CNA beta
CaN Abeta	Calcineurin subunit A beta
protein phosphatase 3, catalytic subunit, beta isozyme	protein phosphatase-2Bb

Ppp3cb Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ppp3cb	P20651	Akap6	Rattus norvegicus	Q9WVC7	Anti Tag CoIP	19883655

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11024	PPP3CB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp3cb	NCBI	NCBI:5532

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