Akap6 - A-kinase anchoring protein 6 Gene

Rattus norvegicus

Also known as mAkap

Gene ID: 64553 | Gene type: protein coding

About Akap6

Summary

Enables several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of cellular protein metabolic process; regulation of intracellular signal transduction; and regulation of muscle system process. Located in several cellular components, including T-tubule; intercalated disc; and junctional sarcoplasmic reticulum membrane. Part of protein-containing complex. Colocalizes with nuclear envelope. Human ortholog(s) of this gene implicated in anorexia nervosa and ovary epithelial Cancer. Orthologous to human AKAP6 (A-kinase anchoring protein 6). [provided by Alliance of Genome Resources, Apr 2022]

Akap6 Products(1)

mRNA	Protein	Name
NM_022618.2	NP_072140.2	A-kinase anchor protein 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenylate cyclase binding	IDA IDA: Inferred from direct assay	19574217	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	15182229	RGD
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	11590243	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15652351	RGD
enables protein kinase A binding	IDA IDA: Inferred from direct assay	10413680	RGD
enables protein kinase A regulatory subunit binding	IDA IDA: Inferred from direct assay	9679148	RGD
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	11590243	RGD
enables protein-membrane adaptor activity	IDA IDA: Inferred from direct assay	10413680	RGD
enables transmembrane transporter binding	IDA IDA: Inferred from direct assay	9679148	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	11590243	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cytokine stimulus	IMP IMP: Inferred from mutant phenotype	16177794	RGD
involved in cellular response to epinephrine stimulus	IMP IMP: Inferred from mutant phenotype	11179196	RGD
involved in negative regulation of adenylate cyclase activity	IMP IMP: Inferred from mutant phenotype	19574217	RGD
involved in positive regulation of cAMP-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	11179196	RGD
involved in positive regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	16306226	RGD
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	16177794	RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development	IDA IDA: Inferred from direct assay	16306226	RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	21550986	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	11179196	RGD
involved in positive regulation of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	12709444	RGD
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	16306226	RGD
involved in protein-containing complex localization	IMP IMP: Inferred from mutant phenotype	11179196	RGD
involved in regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	12709444	RGD
involved in regulation of cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	11179196	RGD
involved in regulation of relaxation of cardiac muscle	IMP IMP: Inferred from mutant phenotype	11179196	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	9679148	RGD
located in caveola	IDA IDA: Inferred from direct assay	20224290	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	9679148	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	9679148	RGD
located in junctional sarcoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	12709444	RGD
located in nuclear envelope	IDA IDA: Inferred from direct assay	10413680	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	10413680	RGD
located in nucleus	IDA IDA: Inferred from direct assay	9679148	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11296225	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11296225	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	9679148	RGD
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	7721854	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A-kinase anchor protein 6

A kinase (PRKA) anchor protein 6	AKAP-6
PRKA6	protein kinase A-anchoring protein 6

Akap6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Akap6	Q9WVC7	Ppp3cb	Rattus norvegicus	P20651	Anti Bait CoIP	19883655

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00521	AKAP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22383	Akap6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28907	Akap6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Akap6	NCBI	NCBI:9472

Name
Email *

	Sorry, but the email address you supplied was invalid.