Pgk1 - phosphoglycerate kinase 1 Gene

Rattus norvegicus

Also known as Pgk

Gene ID: 24644 | Gene type: protein coding

About Pgk1

Summary

Enables ADP binding activity; ATP binding activity; and phosphoglycerate kinase activity. Involved in gluconeogenesis and glycolytic process. Located in cytosol. Human ortholog(s) of this gene implicated in hemolytic anemia and phosphoglycerate kinase 1 deficiency. Orthologous to human PGK1 (phosphoglycerate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pgk1 Products(1)

mRNA	Protein	Name
NM_053291.3	NP_445743.2	phosphoglycerate kinase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IDA IDA: Inferred from direct assay	6405813	RGD
enables ATP binding	IMP IMP: Inferred from mutant phenotype	3091090	RGD
enables phosphoglycerate kinase activity	IDA IDA: Inferred from direct assay	1834654	RGD
enables phosphoglycerate kinase activity	IMP IMP: Inferred from mutant phenotype	3091090	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in gluconeogenesis	IDA IDA: Inferred from direct assay	15720133	RGD
involved in gluconeogenesis	IMP IMP: Inferred from mutant phenotype	3091090	RGD
involved in glycolytic process	IDA IDA: Inferred from direct assay	6405813	RGD
involved in glycolytic process	IMP IMP: Inferred from mutant phenotype	3091090	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phosphoglycerate kinase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134205A	CBR-470-1	Activator	98.02%	Unkown
HY-15154	NG 52	Inhibitor	99.88%	Unkown
HY-W195984	Z57346765		98.53%	Unkown
HY-RS10384	PGK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-127162	Prostaglandin K1		/	Unkown
HY-RS16592	Pgk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23026	Pgk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pgk1	NCBI	NCBI:5230
Mus musculus	Pgk1	NCBI	NCBI:18655

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