Fyb - FYN binding protein Gene

Mus musculus

Also known as ADAP; Fyb1; Slap130; p120/130; p120/p130; FYB-120/130; B630013F22Rik

Gene ID: 23880 | Gene type: protein coding

About Fyb

Summary

The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of Integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Fyb Products(2)

mRNA	Protein	Name
NM_001278269.1	NP_001265198.1	FYN-binding protein 1 isoform 2
NM_011815.5	NP_035945.1	FYN-binding protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12681493	MGI

Biological Process GO Annotation	Evidence	Reference	Source
NOT acts upstream of or within mast cell activation	IMP IMP: Inferred from mutant phenotype	15153494	MGI
acts upstream of or within protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	17403904	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	17403904	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	12681493	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

FYN-binding protein 1

FYN binding protein FYB-130	FYN-T-binding protein
SLP-76-associated phosphoprotein	adhesion and degranulation promoting adaptor protein

Fyb Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Fyb1	O35601	Lcp2	Mus musculus	Q60787	Pull Down	15477347

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05172	FYB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

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