Lcp2 - lymphocyte cytosolic protein 2 Gene

Mus musculus

Also known as twm; SLP76; SLP-76; m1Khoe

Gene ID: 16822 | Gene type: protein coding

About Lcp2

Summary

Acts upstream of or within mast cell activation. Located in cell-cell junction. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human LCP2 (lymphocyte cytosolic protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Lcp2 Products(1)

mRNA	Protein	Name
NM_010696.4	NP_034826.2	lymphocyte cytosolic protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15477347	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cytokine production	IMP IMP: Inferred from mutant phenotype	15153494	MGI
acts upstream of or within mast cell activation	IMP IMP: Inferred from mutant phenotype	15153494	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lymphocyte cytosolic protein 2

SH2 domain-containing leukocyte protein of 76 kDa

SLP-76 tyrosine phosphoprotein

Lcp2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Lcp2	Q60787	Cd6	Mus musculus	Q61003	Affinity Chrom	24584089
Intra	Lcp2	Q60787	Cd6	Mus musculus	Q61003	Anti Bait CoIP	24584089
Intra	Lcp2	Q60787	Lat	Mus musculus	O54957	Affinity Chrom	24584089
Intra	Lcp2	Q60787	Grap2	Mus musculus	O89100	Affinity Chrom	24584089
Intra	Lcp2	Q60787	Fyb1	Mus musculus	O35601	Affinity Chrom	24584089
Intra	Lcp2	Q60787	Fyb1	Mus musculus	O35601	Pull Down	15477347

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07564	LCP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20761	Lcp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27275	Lcp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lcp2	NCBI	NCBI:3937

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