Atrx - ATRX, chromatin remodeler Gene

Mus musculus

Also known as XH2; Xnp; ATR2; MRXS3; Rad54; Hp1bp2; RAD54L; ZNF-HX; Hp1bp38; HP1-BP38; DXHXS6677E; 4833408C14Rik

Gene ID: 22589 | Gene type: protein coding

About Atrx

Summary

Enables chromatin binding activity and histone binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; cellular response to hydroxyurea; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within several processes, including male gonad development; meiotic spindle organization; and post-embryonic forelimb morphogenesis. Located in PML body and chromosome. Is expressed in several structures, including alimentary system; early embryo; egg cylinder; genitourinary system; and nervous system. Used to study alpha thalassemia-X-linked intellectual disability syndrome. Human ortholog(s) of this gene implicated in X-linked mental retardation-hypotonic facies syndrome-1; alpha thalassemia-X-linked intellectual disability syndrome; alpha-thalassemia myelodysplasia syndrome; high grade glioma; and lung small cell carcinoma. Orthologous to human ATRX (ATRX chromatin remodeler). [provided by Alliance of Genome Resources, Apr 2022]

Atrx Products(1)

mRNA	Protein	Name
NM_009530.2	NP_033556.2	transcriptional regulator ATRX

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	15522233	MGI
enables histone binding	IDA IDA: Inferred from direct assay	20211137	MGI
enables histone binding	IPI IPI: Inferred from physical interaction	20110566	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8978696	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	24651726	MGI
acts upstream of or within Sertoli cell development	IMP IMP: Inferred from mutant phenotype	21427128	MGI
involved in cellular response to hydroxyurea	IMP IMP: Inferred from mutant phenotype	24651726	MGI
acts upstream of or within chromosome organization involved in meiotic cell cycle	IMP IMP: Inferred from mutant phenotype	15242786	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	15668733	MGI
acts upstream of or within meiotic spindle organization	IMP IMP: Inferred from mutant phenotype	15242786	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	24386478	MGI
involved in positive regulation of nuclear cell cycle DNA replication	IMP IMP: Inferred from mutant phenotype	24651726	MGI
involved in positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	20110566	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	21427128	MGI
acts upstream of or within post-embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	24386478	MGI
involved in protein localization to chromosome, telomeric region	IMP IMP: Inferred from mutant phenotype	20110566	MGI
involved in replication fork processing	IMP IMP: Inferred from mutant phenotype	24651726	MGI
acts upstream of or within seminiferous tubule development	IMP IMP: Inferred from mutant phenotype	21427128	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	21427128	MGI
involved in subtelomeric heterochromatin formation	IMP IMP: Inferred from mutant phenotype	20211137	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	21427128	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	23444137	MGI
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	23444137	MGI
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	20110566	MGI
located in condensed chromosome, centromeric region	IDA IDA: Inferred from direct assay	15242786	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	14519686	MGI
located in nuclear chromosome	IDA IDA: Inferred from direct assay	11555636	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17296936	MGI
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	15242786	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcriptional regulator ATRX

ATP-dependent helicase ATRX	HP1 alpha-interacting protein
X-linked nuclear protein	heterochromatin protein 2

Atrx Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80004	Adiponectin Antibody (YA639)	WB, ICC/IF, IHC-P	Mouse
HY-P80024	ATRX Antibody (YA828)	ICC/IF, IHC-P	Mouse

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01252	ATRX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19577	Atrx Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26074	Atrx Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atrx	NCBI	NCBI:546

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