Arrb2 - arrestin, beta 2 Gene

Mus musculus

Also known as Arr3

Gene ID: 216869 | Gene type: protein coding

About Arrb2

Summary

Enables protein kinase B binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of cell communication; and regulation of protein phosphorylation. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway and regulation of protein phosphorylation. Predicted to be located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and postsynaptic density. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human ARRB2 (Arrestin beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Arrb2 Products(4)

mRNA	Protein	Name
NM_001271358.1	NP_001258287.1	beta-arrestin-2 isoform a
NM_001271359.1	NP_001258288.1	beta-arrestin-2 isoform a
NM_001271360.1	NP_001258289.1	beta-arrestin-2 isoform b
NM_145429.5	NP_663404.1	beta-arrestin-2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18952848	MGI
enables protein kinase B binding	IPI IPI: Inferred from physical interaction	16051150	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in adult walking behavior	IMP IMP: Inferred from mutant phenotype	16051150	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	27886171	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	27886171	MGI
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	16378096	MGI
involved in negative regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	16378096	MGI
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16378096	MGI
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24974728	MGI
involved in negative regulation of toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16378096	MGI
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16378096	MGI
involved in positive regulation of cardiac muscle cell differentiation	IDA IDA: Inferred from direct assay	24974728	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	24974728	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16051150	MGI
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24974728	MGI
involved in positive regulation of synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	16051150	MGI
involved in postsynaptic signal transduction	IDA IDA: Inferred from direct assay	27886171	MGI
involved in postsynaptic signal transduction	IMP IMP: Inferred from mutant phenotype	27886171	MGI
acts upstream of or within regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	10617462	MGI
acts upstream of or within regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	15218143	MGI
acts upstream of or within regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	15218143	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27886171	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	27886171	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	11171997	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

beta-arrestin-2

arrestin 3

beta arr2

Arrb2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Arrb2	Q91YI4	Ffar4	Mus musculus	Q7TMA4	Confocal	20813258
Intra	Arrb2	Q91YI4	Card10	Mus musculus	P58660	Anti Tag CoIP	18952848

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01029	ARRB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20857	Arrb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27372	Arrb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arrb2	NCBI	NCBI:409

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