Ffar4 - free fatty acid receptor 4 Gene

Mus musculus

Also known as Ffa4; GT01; Pgr4; Gpr120; Gpr129; O3far1; KPG_013

Gene ID: 107221 | Gene type: protein coding

About Ffar4

Summary

Enables G protein-coupled receptor activity; fatty acid binding activity; and Taste Receptor activity. Involved in several processes, including brown fat cell differentiation; positive regulation of cell communication; and positive regulation of cell differentiation. Acts upstream of or within G protein-coupled receptor signaling pathway and hormone secretion. Located in cilium; endocytic vesicle; and plasma membrane. Is expressed in brown fat; intestine; and liver. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FFAR4 (Free Fatty Acid Receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Ffar4 Products(1)

mRNA	Protein	Name
NM_181748.2	NP_861413.1	free fatty acid receptor 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	15619630	MGI
enables fatty acid binding	IDA IDA: Inferred from direct assay	15619630	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20813258	MGI
enables taste receptor activity	IMP IMP: Inferred from mutant phenotype	20573884	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15619630	MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	31761534	MGI
involved in brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	27853148	MGI
involved in fat cell differentiation	IMP IMP: Inferred from mutant phenotype	22343897	MGI
involved in ghrelin secretion	IMP IMP: Inferred from mutant phenotype	24222669	MGI
acts upstream of or within hormone secretion	IDA IDA: Inferred from direct assay	15619630	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15774482	MGI
involved in negative regulation of cytokine production	IDA IDA: Inferred from direct assay	20813258	MGI
acts upstream of or within negative regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	26828067	MGI
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	20813258	MGI
involved in negative regulation of somatostatin secretion	IMP IMP: Inferred from mutant phenotype	24663807	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	27852822	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	15774482	MGI
involved in positive regulation of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	29343498	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	27853148	MGI
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	27852822	MGI
involved in positive regulation of glucagon secretion	IMP IMP: Inferred from mutant phenotype	24742677	MGI
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	26365922	MGI
involved in regulation of D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	20813258	MGI
involved in white fat cell differentiation	IDA IDA: Inferred from direct assay	31761534	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cilium	IDA IDA: Inferred from direct assay	31761534	MGI
located in endocytic vesicle	IDA IDA: Inferred from direct assay	15619630	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15619630	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

free fatty acid receptor 4

G-protein coupled receptor 120	G-protein-coupled receptor GT01
omega-3 fatty acid receptor 1

Ffar4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ffar4	Q7TMA4	Arrb2	Mus musculus	Q91YI4	Anti Tag CoIP	20813258
Intra	Ffar4	Q7TMA4	Arrb2	Mus musculus	Q91YI4	Anti Bait CoIP	20813258

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114610	13Z,16Z-Docosadienoic acid	Agonist	99.00%	Unkown
HY-N3977	Grifolic acid	Agonist	≥98.0%	Unkown
HY-162689	GprA	Agonist	/	Unkown
HY-164870	FFAR1/FFAR4 agonist-1	Agonist	/	Unkown
HY-RS04877	FFAR4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18817	Ffar4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25307	Ffar4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ffar4	NCBI	NCBI:338557

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