Foxp3 - forkhead box P3 Gene

Mus musculus

Also known as sf; JM2; scurfin

Gene ID: 20371 | Gene type: protein coding

About Foxp3

Summary

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene result in the scurfy phenotype (sf). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Foxp3 Products(3)

mRNA	Protein	Name
NM_001199347.1	NP_001186276.1	forkhead box protein P3
NM_001199348.1	NP_001186277.1	forkhead box protein P3
NM_054039.2	NP_473380.1	forkhead box protein P3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17028180	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17028180	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17377532	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	16769892	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17377532	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17028180	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	15790681	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell homeostasis	IMP IMP: Inferred from mutant phenotype	10072494	MGI
acts upstream of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of CD4-positive, alpha-beta T cell differentiation	IDA IDA: Inferred from direct assay	17028180	MGI
acts upstream of CD4-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	17028180	MGI
acts upstream of DNA-templated transcription	IDA IDA: Inferred from direct assay	17028180	MGI
acts upstream of or within T cell activation	IMP IMP: Inferred from mutant phenotype	10072494	MGI
acts upstream of T cell anergy	IMP IMP: Inferred from mutant phenotype	16945588	MGI
acts upstream of or within T cell mediated immunity	IMP IMP: Inferred from mutant phenotype	11714795	MGI
acts upstream of T cell proliferation	IDA IDA: Inferred from direct assay	16769892	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	16203996	MGI
acts upstream of or within T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	10072494	MGI
acts upstream of T cell tolerance induction	IMP IMP: Inferred from mutant phenotype	16945588	MGI
acts upstream of alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	16945588	MGI
acts upstream of or within chromatin remodeling	IDA IDA: Inferred from direct assay	17028180	MGI
acts upstream of or within cytokine production	IDA IDA: Inferred from direct assay	15790681	MGI
acts upstream of or within cytokine production	IGI IGI: Inferred from genetic interaction	7930593	MGI
acts upstream of or within cytokine production	IMP IMP: Inferred from mutant phenotype	7930593	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	28396406	MGI
acts upstream of immature T cell proliferation in thymus	IMP IMP: Inferred from mutant phenotype	16230479	MGI
acts upstream of inflammatory response	IMP IMP: Inferred from mutant phenotype	16203996	MGI
acts upstream of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of interleukin-2 production	IDA IDA: Inferred from direct assay	16769892	MGI
acts upstream of interleukin-4 production	IDA IDA: Inferred from direct assay	16769892	MGI
acts upstream of interleukin-4 production	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of interleukin-5 production	IDA IDA: Inferred from direct assay	16769892	MGI
acts upstream of interleukin-5 production	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of isotype switching to IgE isotypes	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of lymphocyte proliferation	IMP IMP: Inferred from mutant phenotype	16227984	MGI
acts upstream of or within myeloid cell homeostasis	IMP IMP: Inferred from mutant phenotype	10072494	MGI
acts upstream of or within negative regulation of CD4-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	17028180	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15100250	MGI
acts upstream of or within negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	16769892	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	16203996	MGI
acts upstream of or within negative regulation of alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	16945588	MGI
acts upstream of or within negative regulation of chronic inflammatory response	IDA IDA: Inferred from direct assay	16769892	MGI
acts upstream of or within negative regulation of chronic inflammatory response	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: Inferred from direct assay	24501220	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	16203996	MGI
acts upstream of or within negative regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	16275384	MGI
involved in negative regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	18368049	MGI
acts upstream of or within negative regulation of interleukin-2 production	IDA IDA: Inferred from direct assay	16769892	MGI
involved in negative regulation of interleukin-2 production	IDA IDA: Inferred from direct assay	17377532	MGI
involved in negative regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	18368049	MGI
acts upstream of or within negative regulation of interleukin-4 production	IDA IDA: Inferred from direct assay	16769892	MGI
acts upstream of or within negative regulation of interleukin-4 production	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of or within negative regulation of interleukin-5 production	IDA IDA: Inferred from direct assay	16769892	MGI
acts upstream of or within negative regulation of interleukin-5 production	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of or within negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of or within negative regulation of isotype switching to IgE isotypes	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of or within negative regulation of lymphocyte proliferation	IMP IMP: Inferred from mutant phenotype	16227984	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16230479	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16230479	MGI
acts upstream of or within negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of or within negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	16769892	MGI
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	17377532	MGI
acts upstream of or within negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	16275384	MGI
involved in negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	18368049	MGI
acts upstream of or within positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	12612578	MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell differentiation	IDA IDA: Inferred from direct assay	17028180	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17028180	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17377532	MGI
acts upstream of or within positive regulation of T cell anergy	IMP IMP: Inferred from mutant phenotype	16945588	MGI
acts upstream of or within positive regulation of T cell tolerance induction	IMP IMP: Inferred from mutant phenotype	16945588	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	20706986	MGI
acts upstream of or within positive regulation of immature T cell proliferation in thymus	IMP IMP: Inferred from mutant phenotype	16230479	MGI
acts upstream of or within positive regulation of interleukin-4 production	IMP IMP: Inferred from mutant phenotype	20944002	MGI
acts upstream of or within positive regulation of peripheral T cell tolerance induction	IMP IMP: Inferred from mutant phenotype	16532000	MGI
acts upstream of or within positive regulation of regulatory T cell differentiation	IDA IDA: Inferred from direct assay	12522256	MGI
acts upstream of or within positive regulation of regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	15780990	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17028180	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16945588	MGI
acts upstream of or within positive regulation of transforming growth factor beta1 production	IDA IDA: Inferred from direct assay	17028180	MGI
involved in regulation of T cell anergy	IMP IMP: Inferred from mutant phenotype	17377532	MGI
acts upstream of or within regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of or within regulation of isotype switching to IgG isotypes	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18997793	MGI
acts upstream of regulatory T cell differentiation	IDA IDA: Inferred from direct assay	16769892	MGI
acts upstream of or within tolerance induction	IDA IDA: Inferred from direct assay	15809349	MGI
acts upstream of or within tolerance induction to self antigen	IMP IMP: Inferred from mutant phenotype	15780990	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17028180	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16945588	MGI
acts upstream of transforming growth factor beta1 production	IDA IDA: Inferred from direct assay	17028180	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16275384	MGI
acts upstream of type II interferon production	IDA IDA: Inferred from direct assay	16769892	MGI
acts upstream of type II interferon production	IMP IMP: Inferred from mutant phenotype	16275384	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17028180	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	19015308	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16769892	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein P3

scurfy

Foxp3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Foxp3	Q99JB6	Usp44	Mus musculus	Q8C2S0	Confocal	32644293
Intra	Foxp3	Q99JB6	Runx1	Mus musculus	Q03347	Pull Down	17377532
Intra	Foxp3	Q99JB6	Runx1	Mus musculus	Q03347	Anti Tag CoIP	17377532

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13624A	Epirubicin hydrochloride		99.16%	Yes
HY-13624	Epirubicin		98.45%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148808	Zelasudil	Inhibitor	99.33%	Phase 2

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126675A	AS2863619		99.94%	Unkown
HY-124131	DS-437	Inhibitor	98.00%	Unkown
HY-W107024	BMS-986260	Inhibitor	99.95%	Unkown
HY-126675	AS2863619 free base		99.87%	Unkown
HY-P1453A	CMD178 TFA	Inhibitor	99.71%	Unkown
HY-RS05075	FOXP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P1684	Peptide P60	Inhibitor	/	Unkown
HY-P1453	CMD178	Inhibitor	/	Unkown
HY-160040A	Cobitolimod sodium	Agonist	/	Unkown
HY-15091	Anisperimus		/	Unkown
HY-159692	AZD8701	Inhibitor	/	Unkown
HY-159692A	AZD8701 sodium	Inhibitor	/	Unkown
HY-160040	Cobitolimod	Agonist	/	Unkown
HY-162600	CDK8-IN-15	Inhibitor	/	Unkown
HY-162943	P60-L3-VHL		/	Unkown
HY-P10808	RSRGVFF	Inhibitor	/	Unkown
HY-162946	Alkyne-P60		/	Unkown
HY-RS16899	Foxp3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23341	Foxp3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991180	TRX-518	Ligand	/	Unkown
HY-P991392	TGTB227	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxp3	NCBI	NCBI:50943

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