2. Gene
  3. Pstpip1 - proline-serine-threonine phosphatase-interacting protein 1 Gene

Pstpip1 - proline-serine-threonine phosphatase-interacting protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as def-2; CD2BP1

Gene ID: 19200 | Gene type: protein coding

About Pstpip1

Summary

Enables actin binding activity and protein Phosphatase binding activity. Predicted to be involved in actin filament polymerization. Predicted to act upstream of or within several processes, including endocytosis; inflammatory response; and innate immune response. Located in actomyosin contractile ring; cleavage furrow; and stress fiber. Is expressed in several structures, including genitourinary system; lung; musculature; pancreas; and spleen. Human ortholog(s) of this gene implicated in PAPA syndrome. Orthologous to human PSTPIP1 (proline-serine-threonine Phosphatase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Pstpip1 Products(13)

mRNA Protein Name
NM_001409150.1 NP_001396079.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 2
NM_001409151.1 NP_001396080.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 3
NM_001409152.1 NP_001396081.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 4
NM_001409153.1 NP_001396082.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 5
NM_001409154.1 NP_001396083.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 6
NM_001409155.1 NP_001396084.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 7
NM_001409156.1 NP_001396085.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 8
NM_001409157.1 NP_001396086.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 9
NM_001409158.1 NP_001396087.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 10
NM_001409159.1 NP_001396088.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 11
NM_001409160.1 NP_001396089.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 11
NM_001409161.1 NP_001396090.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 11
NM_011193.3 NP_035323.2 proline-serine-threonine phosphatase-interacting protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables actin binding IDA
IDA: Inferred from direct assay
9265651 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9265651 MGI
enables protein phosphatase binding IDA
IDA: Inferred from direct assay
9265651 MGI
Cellular Component GO Annotation Evidence Reference Source
located in actomyosin contractile ring IDA
IDA: Inferred from direct assay
9265651 MGI
located in cleavage furrow IDA
IDA: Inferred from direct assay
9265651 MGI
located in stress fiber IDA
IDA: Inferred from direct assay
9265651 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proline-serine-threonine phosphatase-interacting protein 1

PEST phosphatase-interacting protein 1

Pstpip1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Pstpip1 P97814 Ptpn12 Mus musculus P35831
Anti Bait CoIP
16204241
Intra
Pstpip1 P97814 Ptpn12 Mus musculus P35831
Anti Bait CoIP
11711533
Intra
Pstpip1 P97814 Ptpn12 Mus musculus P35831
IF
11711533
Intra
Pstpip1 P97814 Ptpn18 Mus musculus Q61152
Pull Down
9804817
Intra
Pstpip1 P97814 Abl1 Mus musculus P00520
Anti Tag CoIP
11163214
Intra
Pstpip1 P97814 Abl1 Mus musculus P00520
Anti Bait CoIP
11163214
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11345 PSTPIP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pstpip1 NCBI NCBI:9051