Mlf1 - myeloid leukemia factor 1 Gene

Mus musculus

Also known as HLS7

Gene ID: 17349 | Gene type: protein coding

About Mlf1

Summary

Enables DNA binding activity. Involved in myeloid progenitor cell differentiation and transcription, DNA-templated. Located in several cellular components, including ciliary basal body; ciliary base; and non-motile cilium. Is expressed in several structures, including brain; gonad; immune system; lung; and nasal cavity respiratory epithelium. Orthologous to human MLF1 (myeloid leukemia factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mlf1 Products(2)

mRNA	Protein	Name
NM_001039543.2	NP_001034632.1	myeloid leukemia factor 1 isoform a
NM_010801.3	NP_034931.2	myeloid leukemia factor 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	17008314	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12176995	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA-templated transcription	IDA IDA: Inferred from direct assay	17008314	MGI
involved in myeloid progenitor cell differentiation	IDA IDA: Inferred from direct assay	10523300	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	27914912	MGI
is active in ciliary base	IDA IDA: Inferred from direct assay	27914912	MGI
located in cilium	IDA IDA: Inferred from direct assay	27914912	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12176995	MGI
located in motile cilium	IDA IDA: Inferred from direct assay	23300604	MGI
located in non-motile cilium	IDA IDA: Inferred from direct assay	23300604	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17008314	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myeloid leukemia factor 1

hematopoietic lineage switch 7

myelodysplasia-myeloid leukemia factor 1

Mlf1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mlf1	Q9QWV4	Ywhaz	Mus musculus	P63101	Pull Down	12176995
Intra	Mlf1	Q9QWV4	Ywhaz	Mus musculus	P63101	Y2H	12176995
Intra	Mlf1	Q9QWV4	Nrbp1	Mus musculus	Q99J45	Anti Tag CoIP	12176995
Intra	Mlf1	Q9QWV4	Nrbp1	Mus musculus	Q99J45	Y2H	12176995
Intra	Mlf1	Q9QWV4	Nrbp1	Mus musculus	Q99J45	IF	12176995

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08487	MLF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22237	Mlf1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mlf1	NCBI	NCBI:4291

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