Mecp2 - methyl CpG binding protein 2 Gene

Mus musculus

Also known as Mbd5; WBP10; 1500041B07Rik; D630021H01Rik

Gene ID: 17257 | Gene type: protein coding

About Mecp2

Summary

Enables several functions, including nucleic acid binding activity; promoter-specific chromatin binding activity; and transcription corepressor activity. Involved in several processes, including negative regulation of smooth muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; and positive regulation of histone H3-K9 trimethylation. Acts upstream of or within several processes, including glycerolipid metabolic process; nervous system development; and regulation of gene expression. Located in cytosol; heterochromatin; and nucleus. Is expressed in several structures, including alimentary system; early conceptus; nervous system; paraxial mesenchyme; and sensory organ. Used to study Rett syndrome. Human ortholog(s) of this gene implicated in Rett syndrome; X-linked intellectual disability-psychosis-macroorchidism syndrome; autistic disorder; severe congenital encephalopathy due to MECP2 mutation; and syndromic X-linked intellectual disability Lubs type. Orthologous to human MECP2 (methyl-CpG binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Mecp2 Products(2)

mRNA	Protein	Name
NM_001081979.2	NP_001075448.1	methyl-CpG-binding protein 2 isoform 1
NM_010788.4	NP_034918.1	methyl-CpG-binding protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	18511691	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15608638	MGI
enables double-stranded methylated DNA binding	IDA IDA: Inferred from direct assay	14593184	MGI
enables histone reader activity	IDA IDA: Inferred from direct assay	18511691	MGI
enables histone reader activity	IMP IMP: Inferred from mutant phenotype	17108082	MGI
enables mRNA binding	IDA IDA: Inferred from direct assay	15342650	MGI
enables methyl-CpG binding	IDA IDA: Inferred from direct assay	15342650	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	16782889	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15696166	MGI
enables siRNA binding	IDA IDA: Inferred from direct assay	15342650	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	25722434	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	14593184	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Notch signaling pathway	IDA IDA: Inferred from direct assay	30560934	MGI
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	11242117	MGI
involved in associative learning	IMP IMP: Inferred from mutant phenotype	26158416	MGI
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	16199017	MGI
acts upstream of or within biogenic amine metabolic process	IMP IMP: Inferred from mutant phenotype	15975715	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	18571096	MGI
acts upstream of or within cardiolipin metabolic process	IMP IMP: Inferred from mutant phenotype	17237885	MGI
acts upstream of catecholamine secretion	IMP IMP: Inferred from mutant phenotype	17050729	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15939091	MGI
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	18571096	MGI
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	16399702	MGI
acts upstream of or within dendrite development	IMP IMP: Inferred from mutant phenotype	15519245	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	8563762	MGI
acts upstream of or within epigenetic regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15757975	MGI
acts upstream of or within excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	17920015	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	30560934	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	30560934	MGI
acts upstream of or within genomic imprinting	IMP IMP: Inferred from mutant phenotype	15608638	MGI
acts upstream of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	15939091	MGI
acts upstream of or within glucocorticoid metabolic process	IMP IMP: Inferred from mutant phenotype	17108082	MGI
acts upstream of or within glutamine metabolic process	IMP IMP: Inferred from mutant phenotype	17237885	MGI
acts upstream of or within heterochromatin formation	IMP IMP: Inferred from mutant phenotype	15608638	MGI
acts upstream of or within inositol metabolic process	IMP IMP: Inferred from mutant phenotype	17237885	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	16467389	MGI
acts upstream of or within long-term memory	IMP IMP: Inferred from mutant phenotype	16399702	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	16087343	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	16399702	MGI
acts upstream of or within multicellular organismal response to stress	IMP IMP: Inferred from mutant phenotype	17108082	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18511691	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17108082	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17997046	MGI
involved in negative regulation of smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	25722434	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10888872	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	25722434	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15608638	MGI
acts upstream of or within nervous system process involved in regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	17544925	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	16199017	MGI
acts upstream of or within neuromuscular process controlling posture	IMP IMP: Inferred from mutant phenotype	11242117	MGI
involved in neuron differentiation	IDA IDA: Inferred from direct assay	30560934	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	15345242	MGI
involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	30560934	MGI
acts upstream of or within neuron maturation	IMP IMP: Inferred from mutant phenotype	15519245	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	15345242	MGI
acts upstream of or within phosphatidylcholine metabolic process	IMP IMP: Inferred from mutant phenotype	17237885	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18511691	MGI
acts upstream of or within positive regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	15939091	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16782889	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	16467389	MGI
acts upstream of or within proprioception	IMP IMP: Inferred from mutant phenotype	16467389	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	17296936	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	18203756	MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process	IMP IMP: Inferred from mutant phenotype	16354910	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	16399702	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16467389	MGI
acts upstream of or within respiratory gaseous exchange by respiratory system	IMP IMP: Inferred from mutant phenotype	11242117	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	17997046	MGI
acts upstream of or within response to other organism	IMP IMP: Inferred from mutant phenotype	17997046	MGI
acts upstream of or within sensory perception of pain	IMP IMP: Inferred from mutant phenotype	18321864	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	16199017	MGI
acts upstream of or within startle response	IMP IMP: Inferred from mutant phenotype	18321864	MGI
acts upstream of or within synapse assembly	IMP IMP: Inferred from mutant phenotype	17920015	MGI
acts upstream of trans-synaptic signaling by BDNF	IMP IMP: Inferred from mutant phenotype	17050729	MGI
acts upstream of or within ventricular system development	IMP IMP: Inferred from mutant phenotype	18571096	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	16399702	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17546630	MGI
located in cytosol	IDA IDA: Inferred from direct assay	15939091	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	14519686	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11809720	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

methyl-CpG-binding protein 2

meCp-2 protein

Mecp2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mecp2	Q9Z2D6	Smarca4	Mus musculus	Q3TKT4	Anti Bait CoIP	19602036
Intra	Mecp2	Q9Z2D6	Smarca4	Mus musculus	Q3TKT4	Anti Bait CoIP	24270455
Intra	Mecp2	Q9Z2D6	Smc1a	Mus musculus	Q9CU62	Anti Bait CoIP	20159591
Intra	Mecp2	Q9Z2D6	Smc3	Mus musculus	Q9CW03	Anti Bait CoIP	20159591
Intra	Mecp2	Q9Z2D6	Atrx	Mus musculus	Q61687	Anti Bait CoIP	24270455
Intra	Mecp2	Q9Z2D6	Atrx	Mus musculus	Q61687	Anti Bait CoIP	20159591
Intra	Mecp2	Q9Z2D6	Hdac3	Mus musculus	O88895	Anti Bait CoIP	23770565
Intra	Mecp2	Q9Z2D6	Hdac3	Mus musculus	O88895	Anti Tag CoIP	23770565
Intra	Mecp2	Q9Z2D6	Sin3a	Mus musculus	Q60520	Anti Bait CoIP	19602036
Intra	Mecp2	Q9Z2D6	Sin3a	Mus musculus	Q60520	Anti Bait CoIP	23770565
Intra	Mecp2	Q9Z2D6	Sin3a	Mus musculus	Q60520	Anti Tag CoIP	23770565
Intra	Mecp2	Q9Z2D6	Smarca2	Mus musculus	O35846	Anti Bait CoIP	15696166
Intra	Mecp2	Q9Z2D6	Sp3	Mus musculus	O70494	Anti Bait CoIP	20385708

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08276	MECP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20053	Mecp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26557	Mecp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mecp2	NCBI	NCBI:4204

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