Sin3a - transcriptional regulator, SIN3A (yeast) Gene

Mus musculus

Also known as Sin3; mSin3A; mKIAA4126

Gene ID: 20466 | Gene type: protein coding

About Sin3a

Summary

Enables several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and transcription corepressor activity. Involved in several processes, including cerebral cortex neuron differentiation; negative regulation of circadian rhythm; and regulation of axon extension. Acts upstream of or within several processes, including cellular response to glucose stimulus; positive regulation of G2/M transition of mitotic cell cycle; and response to methylglyoxal. Located in kinetochore and nucleus. Part of transcription repressor complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and retina. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A). [provided by Alliance of Genome Resources, Apr 2022]

Sin3a Products(4)

mRNA	Protein	Name
NM_001110350.1	NP_001103820.1	paired amphipathic helix protein Sin3a isoform 2
NM_001110351.1	NP_001103821.1	paired amphipathic helix protein Sin3a isoform 1
NM_001357754.1	NP_001344683.1	paired amphipathic helix protein Sin3a isoform 1
NM_011378.2	NP_035508.2	paired amphipathic helix protein Sin3a isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14593184	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19235719	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	17074803	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7889570	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	7889570	MGI
enables transcription corepressor activity	IGI IGI: Inferred from genetic interaction	10734093	MGI
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	15998811	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	14593184	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA replication	IMP IMP: Inferred from mutant phenotype	15998811	MGI
acts upstream of or within cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	17670746	MGI
involved in cerebral cortex neuron differentiation	IMP IMP: Inferred from mutant phenotype	27399968	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	24029230	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	15998811	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7889570	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15998811	MGI
involved in negative regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	21680841	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	7889570	MGI
acts upstream of or within positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	15998811	MGI
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	27399968	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	15998811	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15998811	MGI
involved in regulation of axon extension	IMP IMP: Inferred from mutant phenotype	27399968	MGI
acts upstream of or within response to methylglyoxal	IDA IDA: Inferred from direct assay	17670746	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in kinetochore	IDA IDA: Inferred from direct assay	14519686	MGI
located in nucleus	IDA IDA: Inferred from direct assay	8649810	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	17182846	MGI
part of transcription repressor complex	IDA IDA: Inferred from direct assay	10734093	MGI
part of transcription repressor complex	IPI IPI: Inferred from physical interaction	17182846	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

paired amphipathic helix protein Sin3a

histone deacetylase complex subunit Sin3a	transcriptional corepressor Sin3a
transcriptional regulator, SIN3 yeast homolog A

Sin3a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sin3a	Q60520	Mecp2	Mus musculus	Q9Z2D6	Anti Bait CoIP	23770565
Intra	Sin3a	Q60520	Hdac1	Mus musculus	O09106	Anti Bait CoIP	19424149
Intra	Sin3a	Q60520	Hdac1	Mus musculus	O09106	Anti Bait CoIP	21448134
Intra	Sin3a	Q60520	Hdac1	Mus musculus	O09106	Anti Bait CoIP	24240174
Intra	Sin3a	Q60520	Hdac1	Mus musculus	O09106	Anti Bait CoIP	20404188
Intra	Sin3a	Q60520	Hdac2	Mus musculus	P70288	Anti Bait CoIP	19424149
Intra	Sin3a	Q60520	Hdac2	Mus musculus	P70288	Anti Bait CoIP	20404188
Intra	Sin3a	Q60520	Hdac2	Mus musculus	P70288	Anti Bait CoIP	24240174
Intra	Sin3a	Q60520	Tet1	Mus musculus	Q3URK3	Anti Bait CoIP	21490601
Intra	Sin3a	Q60520	Suds3	Mus musculus	Q8BR65	Y2H	11909966
Intra	Sin3a	Q60520	Suds3	Mus musculus	Q8BR65	Pull Down	11909966
Intra	Sin3a	Q60520	Sap30	Mus musculus	O88574	CoIP	9702189
Intra	Sin3a	Q60520	Sap30	Mus musculus	O88574	Y2H	9702189
Intra	Sin3a	Q60520	Sap30	Mus musculus	O88574	Pull Down	9702189
Intra	Sin3a	Q60520	Sap30	Mus musculus	O88574	Anti Tag CoIP	9702189
Cross	Sin3a	Q60520	MNT	Homo sapiens	Q99583	Anti Bait CoIP	9184233
Cross	Sin3a	Q60520	MNT	Homo sapiens	Q99583	Y2H	9184233

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3242	Mad1 (6-21)		98.02%	Unkown
HY-RS12925	SIN3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P3242A	Mad1 (6-21) TFA		/	Unkown
HY-RS20104	Sin3a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26607	Sin3a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sin3a	NCBI	NCBI:25942

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