2. Gene
  3. Smc1a - structural maintenance of chromosomes 1A Gene

Smc1a - structural maintenance of chromosomes 1A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Smc1; Smcb; Sb1.8; SMC-1A; Smc1l1; Smc1alpha; mKIAA0178; 5830426I24Rik

Gene ID: 24061 | Gene type: protein coding

About Smc1a

Summary

Enables chromatin binding activity and mediator complex binding activity. Acts upstream of or within meiotic cell cycle and stem cell population maintenance. Located in nucleus. Part of meiotic cohesin complex. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2 and developmental and epileptic encephalopathy. Orthologous to human SMC1A (structural maintenance of chromosomes 1A). [provided by Alliance of Genome Resources, Apr 2022]

Smc1a Products(1)

mRNA Protein Name
NM_019710.2 NP_062684.2 structural maintenance of chromosomes protein 1A
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
20720539 MGI
enables mediator complex binding IDA
IDA: Inferred from direct assay
20720539 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10375619 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within meiotic cell cycle IPI
IPI: Inferred from physical interaction
12759374 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
20720539 MGI
Cellular Component GO Annotation Evidence Reference Source
part of cohesin complex IDA
IDA: Inferred from direct assay
10375619 MGI
part of meiotic cohesin complex IDA
IDA: Inferred from direct assay
21527826 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10375619 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

structural maintenance of chromosomes protein 1A

SMC (segregation of mitotic chromosomes 1)-like 1

SMC protein 1A

SMC-1-alpha

chromosome segregation protein SmcB

segregation of mitotic chromosomes b

Smc1a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Smc1a Q9CU62 Mecp2 Mus musculus Q9Z2D6
Anti Bait CoIP
20159591
Intra
Smc1a Q9CU62 Atrx Mus musculus Q61687
Anti Bait CoIP
20159591
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13416 SMC1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22809 Smc1a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smc1a NCBI NCBI:8243