Ccna2 - cyclin A2 Gene

Mus musculus

Also known as Ccn1; Ccna; Cyca; Ccn-1; CycA2

Gene ID: 12428 | Gene type: protein coding

About Ccna2

Summary

Enables protein kinase binding activity. Acts upstream of or within positive regulation of transcription, DNA-templated. Located in cytoplasm; female pronucleus; and male pronucleus. Part of cyclin A2-CDK2 complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human CCNA2 (cyclin A2). [provided by Alliance of Genome Resources, Apr 2022]

Ccna2 Products(1)

mRNA	Protein	Name
NM_009828.3	NP_033958.2	cyclin-A2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11331592	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11981756	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	16137671	MGI
acts upstream of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16137671	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	16137671	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16137671	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of cyclin A2-CDK1 complex	IPI IPI: Inferred from physical interaction	19592082	MGI
part of cyclin A2-CDK2 complex	IDA IDA: Inferred from direct assay	7739547	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15159393	MGI
located in female pronucleus	IDA IDA: Inferred from direct assay	16137671	MGI
located in male pronucleus	IDA IDA: Inferred from direct assay	16137671	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15159393	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cyclin-A2

Cyclin A2 (Cyclin A)

cyclin-A

Ccna2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ccna2	P51943	CDK2	Homo sapiens	P24941	GMS	21565702
Cross	Ccna2	P51943	CDK2	Homo sapiens	P24941	X-Ray Diffraction	21565702
Intra	Ccna2	P51943	Cdk1	Mus musculus	P11440	Anti Bait CoIP	19592082
Intra	Ccna2	P51943	Cdk2	Mus musculus	P97377	Anti Bait CoIP	19592082

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W097625	6-Methoxyflavone		99.87%	Unkown
HY-174321	A2073	Inhibitor	/	Unkown
HY-RS02117	CCNA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18168	Ccna2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24642	Ccna2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccna2	NCBI	NCBI:890

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