Bcr - BCR activator of RhoGEF and GTPase Gene

Mus musculus

Also known as mKIAA3017; 5133400C09Rik

Gene ID: 110279 | Gene type: protein coding

About Bcr

Summary

Enables GTPase activator activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of cellular extravasation; and regulation of vascular permeability. Acts upstream of or within several processes, including animal organ development; cellular response to lipopolysaccharide; and regulation of vesicle-mediated transport. Located in cytosol; plasma membrane; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including cardiovascular system; central nervous system; forelimb bud; genitourinary system; and spleen. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Bcr Products(1)

mRNA	Protein	Name
NM_001081412.2	NP_001074881.1	breakpoint cluster region protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	17116687	MGI
enables GTPase activator activity	IGI IGI: Inferred from genetic interaction	19703997	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17000758	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	17116687	MGI
acts upstream of or within brain development	IGI IGI: Inferred from genetic interaction	11684658	MGI
acts upstream of cell migration	IGI IGI: Inferred from genetic interaction	17116687	MGI
acts upstream of or within cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	7889565	MGI
acts upstream of or within definitive hemopoiesis	IMP IMP: Inferred from mutant phenotype	7889565	MGI
acts upstream of establishment of localization in cell	IGI IGI: Inferred from genetic interaction	17116687	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	7889565	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	11921339	MGI
acts upstream of or within intracellular protein transmembrane transport	IMP IMP: Inferred from mutant phenotype	7889565	MGI
acts upstream of macrophage migration	IGI IGI: Inferred from genetic interaction	17116687	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	20962234	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	20962234	MGI
involved in negative regulation of blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	23152932	MGI
involved in negative regulation of cellular extravasation	IMP IMP: Inferred from mutant phenotype	23152932	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	19703997	MGI
acts upstream of or within negative regulation of macrophage migration	IGI IGI: Inferred from genetic interaction	17116687	MGI
acts upstream of or within negative regulation of neutrophil degranulation	IGI IGI: Inferred from genetic interaction	19703997	MGI
acts upstream of or within negative regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	7889565	MGI
acts upstream of or within negative regulation of respiratory burst	IMP IMP: Inferred from mutant phenotype	7889565	MGI
acts upstream of or within neuromuscular process controlling balance	IGI IGI: Inferred from genetic interaction	11921339	MGI
acts upstream of neutrophil degranulation	IGI IGI: Inferred from genetic interaction	19703997	MGI
acts upstream of phagocytosis	IGI IGI: Inferred from genetic interaction	17116687	MGI
acts upstream of or within positive regulation of phagocytosis	IGI IGI: Inferred from genetic interaction	17116687	MGI
acts upstream of or within regulation of cell cycle	IDA IDA: Inferred from direct assay	11809706	MGI
involved in regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	23152932	MGI
acts upstream of or within renal system process	IMP IMP: Inferred from mutant phenotype	7889565	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	19703997	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	20962234	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	20962234	MGI
located in cytosol	IDA IDA: Inferred from direct assay	17116687	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20962234	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20962234	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17116687	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	25331951	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

breakpoint cluster region protein

breakpoint cluster region homolog

Related Agents

Approval

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10181	Dasatinib		99.85%	Yes
HY-15463	Imatinib		99.95%	Yes
HY-10159	Nilotinib		99.94%	Yes
HY-50946	Imatinib Mesylate		99.98%	Yes
HY-104010	Asciminib	Inhibitor	99.61%	Yes
HY-15666	Olverembatinib	Inhibitor	99.47%	Yes
HY-10181A	Dasatinib hydrochloride		99.67%	Yes
HY-10159A	Nilotinib monohydrochloride monohydrate		99.91%	Yes
HY-129390	Orelabrutinib	Inhibitor	99.97%	Yes
HY-13904	Flumatinib	Inhibitor	99.94%	Unkown
HY-15728	Radotinib		99.19%	Yes
HY-104010A	Asciminib hydrochloride	Inhibitor	99.84%	Yes
HY-10181B	Dasatinib monohydrate		99.58%	Yes
HY-15666A	Olverembatinib dimesylate	Inhibitor	99.80%	Yes
HY-13905	Flumatinib mesylate	Inhibitor	99.80%	Unkown
HY-10159B	Nilotinib hydrochloride		/	Unkown
HY-50946R	Imatinib Mesylate (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13024	Rebastinib		99.91%	Phase 2
HY-50868	Bafetinib		99.18%	Phase 2
HY-137460	Vodobatinib	Inhibitor	98.09%	Phase 2
HY-109010	Poseltinib	Inhibitor	98.08%	Phase 2
HY-109082	Cevidoplenib	Inhibitor	99.58%	Phase 2
HY-120508	Pivanex		95.0%	Phase 2
HY-15493	AN-019	Inhibitor	/	Phase 2
HY-15749	XL228	Inhibitor	99.64%	Phase 1
HY-103275	Adaphostin		99.02%	Phase 1
HY-118084	LS-104		/	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99761	Obexelimab		99.99%	Phase 3
HY-P991086	MGD010	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (122)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13520	Nocodazole		99.59%	Unkown
HY-13264	Degrasyn		99.70%	Unkown
HY-147308	Zelenirstat	Inhibitor	99.76%	Unkown
HY-125845	(S,R,S)-AHPC		99.13%	Unkown
HY-15738	GNF-5	Inhibitor	99.95%	Unkown
HY-11007	GNF-2	Inhibitor	99.82%	Unkown
HY-125834	GMB-475		98.69%	Unkown
HY-158145	DS55980254	Inhibitor	99.65%	Unkown
HY-10943	GNF-7	Inhibitor	99.70%	Unkown
HY-157562	DS68591889		99.18%	Unkown
HY-152036A	SIAIS100 TFA	Degrader	99.75%	Unkown
HY-128756	SIAIS178	Inhibitor	99.36%	Unkown
HY-153415	PROTAC BCR-ABL Degrader-1	Degrader	98.73%	Unkown
HY-10181S	Dasatinib-d8		99.15%	Unkown
HY-13943	CNX-774	Inhibitor	99.92%	Unkown
HY-153357	NRX-0492	Degrader	98.16%	Unkown
HY-103274	PD180970		99.27%	Unkown
HY-18010	PCI 29732	Inhibitor	99.86%	Unkown
HY-136268	AQX-435	Activator	99.15%	Unkown
HY-147414	Vamotinib	Inhibitor	98.69%	Unkown
HY-100338	CNX-500	Inhibitor	99.88%	Unkown
HY-10159S	Nilotinib-d6		99.95%	Unkown
HY-131669	Dasatinib metabolite M6		99.64%	Unkown
HY-103032	Multi-kinase inhibitor 1	Inhibitor	99.34%	Unkown
HY-15463S	Imatinib-d8		99.88%	Unkown
HY-107447	N-Deshydroxyethyl Dasatinib		98.58%	Unkown
HY-15814	HG-7-85-01		99.94%	Unkown
HY-15463S1	Imatinib-d4		99.86%	Unkown
HY-157327	AKE-72	Inhibitor	98.29%	Unkown
HY-101489A	GZD856 formic		95.36%	Unkown
HY-123450	S116836		99.60%	Unkown
HY-145887	BCR-ABL1-IN-1		99.82%	Unkown
HY-117718	AG957	Inhibitor	99.30%	Unkown
HY-123159	AKI603	Inhibitor	98.03%	Unkown
HY-13904S	Flumatinib-d3	Inhibitor	99.9%	Unkown
HY-153008	BCR-ABL-IN-7	Inhibitor	99.66%	Unkown
HY-156148	BCR-ABL-IN-8	Inhibitor	/	Unkown
HY-111872	SNIPER(ABL)-020	Inhibitor	99.79%	Unkown
HY-108486	Herbimycin A	Inhibitor	99%	Unkown
HY-123390	DB07107	Inhibitor	/	Unkown
HY-130297	PROTAC BCR-ABL1 ligand 1	Inhibitor	99.17%	Unkown
HY-133794	Dasatinib N-oxide		99.24%	Unkown
HY-15463S2	Imatinib-d3 hydrochloride		95.19%	Unkown
HY-10159C	Nilotinib hydrochloride dihydrate		99.89%	Unkown
HY-10181S1	Dasatinib-d4		97.54%	Unkown
HY-41940	Dasatinib intermediate-1	Control	≥98.0%	Unkown
HY-101489	GZD856		/	Unkown
HY-108704	CT-721	Inhibitor	/	Unkown
HY-110402	(S,R,S)-AHPC TFA		/	Unkown
HY-111871	SNIPER(ABL)-033	Inhibitor	/	Unkown
HY-128607	Mcl1-IN-9	Inhibitor	/	Unkown
HY-136526	BCR-ABL-IN-3	Inhibitor	/	Unkown
HY-111851	SNIPER(ABL)-049	Inhibitor	/	Unkown
HY-111854	SNIPER(ABL)-015	Inhibitor	/	Unkown
HY-111858	SNIPER(ABL)-050	Inhibitor	/	Unkown
HY-111859	SNIPER(ABL)-058	Inhibitor	/	Unkown
HY-111860	SNIPER(ABL)-013	Inhibitor	/	Unkown
HY-111861	SNIPER(ABL)-024	Inhibitor	/	Unkown
HY-111862	SNIPER(ABL)-044	Inhibitor	/	Unkown
HY-111873	SNIPER(ABL)-019	Inhibitor	/	Unkown
HY-133794S	Dasatinib N-oxide-d8		/	Unkown
HY-100314	BCR-ABL-IN-1	Inhibitor	/	Unkown
HY-101268	CHMFL-ABL-053	Inhibitor	/	Unkown
HY-10159S1	Nilotinib-13C,d3		/	Unkown
HY-101763B	(S,R,S)-AHPC dihydrochloride		/	Unkown
HY-10181G	Dasatinib (GMP)		/	Unkown
HY-111863	SNIPER(ABL)-047	Inhibitor	/	Unkown
HY-111874	SNIPER(ABL)-039	Inhibitor	/	Unkown
HY-119177	PD173956	Inhibitor	/	Unkown
HY-120036	Tyrphostin AG1112	Inhibitor	/	Unkown
HY-125090	PHA-680626		/	Unkown
HY-126143	CHMFL-ABL-039	Inhibitor	/	Unkown
HY-131275	Imatinib Impurity E		96.05%	Unkown
HY-142922	BCR-ABL-IN-4	Inhibitor	/	Unkown
HY-147581	BTK-IN-11	Inhibitor	/	Unkown
HY-147584	BTK-IN-14	Inhibitor	/	Unkown
HY-150566	BCR-ABL-IN-5	Inhibitor	/	Unkown
HY-150569	BCR-ABL-IN-6	Inhibitor	/	Unkown
HY-150908	Brigatinib A		/	Unkown
HY-152036	SIAIS100	Degrader	/	Unkown
HY-153085	CD19 CAR circRNA		/	Unkown
HY-153234	CD19 car circRNA-LNP		/	Unkown
HY-153582	ML 2-23	Degrader	/	Unkown
HY-15728S	Radotinib-d6		/	Unkown
HY-157389	AK-HW-90	Inhibitor	/	Unkown
HY-160478	GNF-6	Inhibitor	/	Unkown
HY-161323	FLT3-ITD/D835Y-IN-1		/	Unkown
HY-161445	(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH		/	Unkown
HY-162257	BTK-IN-34	Inhibitor	/	Unkown
HY-162489	Tyrosine kinase-IN-8	Inhibitor	/	Unkown
HY-162698	JMF4073	Inhibitor	/	Unkown
HY-162952	cSRC/BCR-ABL1-IN-1	Inhibitor	/	Unkown
HY-168963	PROTAC BTK Degrader-13		/	Unkown
HY-169230	BCR-ABL-IN-9	Inhibitor	/	Unkown
HY-169231	BCR-ABL-IN-10	Inhibitor	/	Unkown
HY-171184	EAPB0503		/	Unkown
HY-172096	cSRC/BCR-ABL-IN-1	Inhibitor	/	Unkown
HY-176269	VS1150		/	Unkown
HY-177273	Kinase modulator-1	Inhibitor	/	Unkown
HY-18819	BCR-ABL-IN-2	Inhibitor	/	Unkown
HY-E70634	ABL1 E255K Recombinant Human Active Protein Kinase		/	Unkown
HY-E70635	ABL1 F317I Recombinant Human Active Protein Kinase		/	Unkown
HY-E70636	ABL1 G250E Recombinant Human Active Protein Kinase		/	Unkown
HY-E70637	ABL1 H396P Recombinant Human Active Protein Kinase		/	Unkown
HY-E70638	ABL1 M351T Recombinant Human Active Protein Kinase		/	Unkown
HY-E70639	ABL1 Q252H Recombinant Human Active Protein Kinase		/	Unkown
HY-E70640	ABL1 T315I Recombinant Human Active Protein Kinase		/	Unkown
HY-E70641	ABL1 Y253F Recombinant Human Active Protein Kinase		/	Unkown
HY-E70789	BCR-RET Recombinant Human Active Protein Kinase		/	Unkown
HY-E70808	BTK C481R Recombinant Human Active Protein Kinase		/	Unkown
HY-E70809	BTK V416L Recombinant Human Active Protein Kinase		/	Unkown
HY-RS01450	BCR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-123486	HS-438		/	Unkown
HY-132549S	Nilotinib-d3		/	Unkown
HY-15463S3	Imatinib-13C,d3		/	Unkown
HY-160174	BCR-ABL kinase-IN-3	Inhibitor	/	Unkown
HY-160174A	BCR-ABL kinase-IN-3 (dihydrocholide)	Inhibitor	/	Unkown
HY-164393	ON044580		/	Unkown
HY-164469	CHMFL-48	Inhibitor	/	Unkown
HY-169608	BCR-ABL-IN-11	Inhibitor	/	Unkown
HY-RS16598	Bcr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23032	Bcr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bcr	NCBI	NCBI:613

Name
Email *

	Sorry, but the email address you supplied was invalid.