2. Autophagy Protein Tyrosine Kinase/RTK
  3. Autophagy Bcr-Abl
  4. Nilotinib hydrochloride dihydrate

Nilotinib hydrochloride dihydrate  (Synonyms: AMN107 hydrochloride dihydrate)

Cat. No.: HY-10159C
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Nilotinib (AMN107) hydrochloride dihydrate is an orally active Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity and can be used in studies of chronic myelogenous leukaemia.

For research use only. We do not sell to patients.

Nilotinib hydrochloride dihydrate Chemical Structure

Nilotinib hydrochloride dihydrate Chemical Structure

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Based on 41 publication(s) in Google Scholar

Other Forms of Nilotinib hydrochloride dihydrate:

Nilotinib hydrochloride dihydrate Related Antibodies

Top Publications Citing Use of Products

39 Publications Citing Use of MCE Nilotinib hydrochloride dihydrate

Proliferation Assay
IHC

    Nilotinib hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2018 Apr 24;9(31):22158-22183.  [Abstract]

    Primary tumors are dissected at the end of experiment and subjected to immunohistochemistry. Representative images of primary tumor sections stained with anti-PCNA (proliferation), anti-cleaved caspase 3 (apoptosis), and anti-CD31 (angiogenesis).

    Nilotinib hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: Leuk Lymphoma. 2015;56(8):2416-23.  [Abstract]

    Cell cycle analysis of HT93A cells by flow cytometry. Cells are treated with 100 nM Nilotinib and 50 ng/mL G-CSF alone or in combination for 48 h before the cell cycle is analyzed. Nilotinib treatment increases the fraction of cells in G0/G1 phase and decreased the S+G2/M-phase fraction.

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    Description

    Nilotinib (AMN107) hydrochloride dihydrate is an orally active Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity and can be used in studies of chronic myelogenous leukaemia[1][2][3].

    Molecular Weight

    602.01

    Formula

    C28H27ClF3N7O3
    SMILES

    O=C(NC1=CC(C(F)(F)F)=CC(N2C=NC(C)=C2)=C1)C3=CC=C(C)C(NC4=NC=CC(C5=CC=CN=C5)=N4)=C3.O.O.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Nilotinib hydrochloride dihydrate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Nilotinib hydrochloride dihydrateAMN107 hydrochloride dihydrateAutophagyBcr-Abltyrosine kinaseantitumorInhibitorinhibitorinhibit

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