Ogt - O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) Gene

Mus musculus

Also known as Ogtl; 1110038P24Rik; 4831420N21Rik

Gene ID: 108155 | Gene type: protein coding

About Ogt

Summary

Enables protein O-GlcNAc transferase activity. Involved in several processes, including circadian regulation of gene expression; positive regulation of cold-induced thermogenesis; and regulation of gluconeogenesis. Acts upstream of or within protein O-linked glycosylation. Predicted to be located in several cellular components, including euchromatin; neuronal cell body; and zymogen granule. Predicted to be part of Histone Acetyltransferase complex and protein N-acetylglucosaminyltransferase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Apr 2022]

Ogt Products(2)

mRNA	Protein	Name
NM_001290535.1	NP_001277464.1	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2
NM_139144.4	NP_631883.2	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	22878500	MGI
enables protein O-acetylglucosaminyltransferase activity	IDA IDA: Inferred from direct assay	21471514	MGI
enables protein O-acetylglucosaminyltransferase activity	IMP IMP: Inferred from mutant phenotype	23395176	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17670746	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23395176	MGI
involved in hemopoiesis	IMP IMP: Inferred from mutant phenotype	33406421	MGI
involved in mitophagy	IMP IMP: Inferred from mutant phenotype	33406421	MGI
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	23395176	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	28637651	MGI
involved in positive regulation of lipid biosynthetic process	IDA IDA: Inferred from direct assay	21471514	MGI
involved in positive regulation of transcription from RNA polymerase II promoter by glucose	IDA IDA: Inferred from direct assay	21471514	MGI
acts upstream of or within protein O-linked glycosylation	IDA IDA: Inferred from direct assay	17670746	MGI
involved in regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	23395176	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	28143929	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEP IEP: Inferred from expression pattern	28143929	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	28143929	MGI
involved in regulation of synapse assembly	IDA IDA: Inferred from direct assay	28143929	MGI
involved in regulation of synapse assembly	IEP IEP: Inferred from expression pattern	28143929	MGI
involved in regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	28143929	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28143929	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	28143929	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	28143929	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	21471514	MGI
is active in synapse	IDA IDA: Inferred from direct assay	28143929	MGI
is active in synapse	IEP IEP: Inferred from expression pattern	28143929	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

O-GlcNAc transferase subunit p110

O-linked N-acetylglucosamine transferase 110 kDa subunit

Ogt Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ogt	Q8CGY8	Tet2	Mus musculus	Q4JK59	Anti Bait CoIP	23222540

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119738	OSMI-1	Inhibitor	99.90%	Unkown
HY-114361	OSMI-4	Inhibitor	99.69%	Unkown
HY-112174	UDP-GlcNAc disodium		99.92%	Unkown
HY-145934	UDP-GalNAz disodium	Substrate	99.78%	Unkown
HY-145934A	UDP-GlcNAz disodium	Substrate	99.74%	Unkown
HY-136282	OGT-IN-2	Inhibitor	99.82%	Unkown
HY-139793	UDP-glucosamine disodium		99.43%	Unkown
HY-135784	OSMI-2	Inhibitor	98.73%	Unkown
HY-101548	OGT-IN-1	Inhibitor	98.14%	Unkown
HY-148113	PG 34		≥98.0%	Unkown
HY-119738A	(Rac)-OSMI-1	Inhibitor	96.51%	Unkown
HY-135785	OSMI-3	Inhibitor	99.08%	Unkown
HY-125278	OGT-IN-4	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ogt	NCBI	NCBI:8473

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