Tet2 - tet methylcytosine dioxygenase 2 Gene

Mus musculus

Also known as Ayu17-449; mKIAA1546; E130014J05Rik

Gene ID: 214133 | Gene type: protein coding

About Tet2

Summary

Enables methylcytosine dioxygenase activity. Involved in cellular protein modification process; myeloid cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including DNA demethylation; animal organ development; and hematopoietic stem cell homeostasis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; extraembryonic component; lower urogenital tract; reproductive system; and urethra epithelium. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tet2 Products(2)

mRNA	Protein	Name
NM_001040400.2	NP_001035490.2	methylcytosine dioxygenase TET2 isoform 1
NM_001346736.1	NP_001333665.1	methylcytosine dioxygenase TET2 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5-methylcytosine dioxygenase activity	IDA IDA: Inferred from direct assay	19372391	MGI
enables 5-methylcytosine dioxygenase activity	IMP IMP: Inferred from mutant phenotype	21057493	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23222540	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chromosomal 5-methylcytosine DNA demethylation, oxidation pathway	IMP IMP: Inferred from mutant phenotype	21803851	MGI
acts upstream of or within cytosine metabolic process	IMP IMP: Inferred from mutant phenotype	21803851	MGI
acts upstream of or within hematopoietic stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	21803851	MGI
acts upstream of or within hemoglobin metabolic process	IMP IMP: Inferred from mutant phenotype	21803851	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	21723200	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	21803851	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	18288583	MGI
acts upstream of or within liver morphogenesis	IMP IMP: Inferred from mutant phenotype	21803851	MGI
involved in myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	21057493	MGI
acts upstream of or within myeloid progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	21803851	MGI
acts upstream of or within positive regulation of gene expression via chromosomal CpG island demethylation	IDA IDA: Inferred from direct assay	20639862	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23353889	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	18288583	MGI
involved in protein O-linked glycosylation	IMP IMP: Inferred from mutant phenotype	23353889	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	21803851	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

methylcytosine dioxygenase TET2

probable methylcytosine dioxygenase TET2	tet oncogene 2
tet oncogene family member 2

Tet2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Tet2	Q4JK59	Ogt	Mus musculus	Q8CGY8	Anti Bait CoIP	23222540

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111558	Bobcat339	Inhibitor	99.44%	Unkown
HY-111558A	Bobcat339 hydrochloride	Inhibitor	99.59%	Unkown
HY-402410	TETi76	Inhibitor	97.49%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tet2	NCBI	NCBI:54790

Name
Email *

	Sorry, but the email address you supplied was invalid.