Bisphenol C 

Bisphenol C is an estrogen receptor-α (ERα) agonist and an ERβ antagonist, with IC₅₀ values of 2.65 nM for ERα and 1.94 nM for ERβ. Bisphenol C is a material of manufacturing polyester polymers like polycarbonate, is widely used in daily items like water bottles, food packaging, textile and so on^[1][2][3].

Bisphenol C (41-150 nM) induces cardiac defects in zebrafish. Bisphenol C disrupts m6A homeostasis by downregulation of the key m6A methyltransferase, Mettl3, thereby causing the m6A reader, Igf2bp2b, to fail in recognizing and stabilizing the inefficiently m6A-modified acox1 and tnnt2d mRNA. Then, downregulation of Acox1 (a regulator in cardiac fatty acid metabolism) and Tnnt2d (a component of cardiac troponin for muscle contraction) led to cardiac defects^[2].
Bisphenol C exposure leading to liver and intestinal developmental defects in zebrafish, which occurres via disruption of GPER-AKT-mTOR-RPS6 pathway. Bisphenol C downregulates phosphorylated and total levels of mTOR, which synergistically reduced the phosphorylation of RPS6, suppressing the translation of genes essential for cell proliferation in liver and intestine such as yap1 and tcf4^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

256.34

C₁₇H₂₀O₂

79-97-0

Solid

White to off-white

CC1=CC(=CC=C1O)C(C)(C)C2=CC=C(C(=C2)C)O

Room temperature in continental US; may vary elsewhere.

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

• [1]. Xiaohui Liu, et al. Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding. PLoS One. 2021 Feb 9;16(2):e0246583.  [Content Brief]

  [2]. Su K, et al. Bisphenol C Induces Cardiac Developmental Defects by Disrupting m6A Homeostasis. Environ Sci Technol. 2024 Oct 1;58(39):17259-17269.  [Content Brief]

  [3]. Liu J, et al. Bisphenol C induces developmental defects in liver and intestine through mTOR signaling in zebrafish (Danio rerio). Chemosphere. 2023 May;322:138195.  [Content Brief]