2. Signaling Pathways
  3. Anti-infection
  4. Virus Protease

Virus Protease

Virus Protease

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Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-139602
    (+)-JNJ-A07
    		Inhibitor 98.46%
    (+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against a panel of 21 clinical isolates. (+)-JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models.
    (+)-JNJ-A07
  • HY-100576
    NH125
    		Inhibitor 99.63%
    NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII), also can induce eEF2 phosphorylation, with an IC50 of 60 nM for eEF-2K.
    NH125
  • HY-19711
    STING agonist-1
    		Inhibitor 99.59%
    STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.
    STING agonist-1
  • HY-B0448A
    Phenytoin sodium
    		Inhibitor 99.84%
    Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.
    Phenytoin sodium
  • HY-N0017
    Bergenin
    		Inhibitor 99.21%
    Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties.
    Bergenin
  • HY-N0763
    Angelicin
    		Inhibitor 99.98%
    Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC50=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.
    Angelicin
  • HY-N0470
    L-Lysine hydrochloride
    		Inhibitor ≥98.0%
    L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine hydrochloride
  • HY-P3042
    Chymostatin
    		Inhibitor ≥99.0%
    Chymostatin is a SARS-CoV-2 Mpro inhibitor. Chymostatin up-regulates endocan and inhibits NF-κBp65 activity. Chymostatin reduces proinflammatory cytokines (IL-1β and IL-6) and HMGB1. Chymostatin shows protective effects against Paraquat-induced acute lung injury. Chymostatin exhibits anticancer activity against lung cancer.
    Chymostatin
  • HY-N0731
    Genkwanin
    		Inhibitor 99.82%
    Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities.
    Genkwanin
  • HY-N0690
    Schisandrin C
    		Inhibitor 99.95%
    Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis. Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory and antioxidant effects. Schisandrin C is a molecular glue. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases research. Schisandrin C induces cell apoptosis.
    Schisandrin C
  • HY-N7108
    7-Hydroxyflavone
    		Inhibitor 99.84%
    7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC50 of 2.12 μM. 7-Hydroxyflavone inhibits COX-2 and 5-LOX with IC50 of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active.
    7-Hydroxyflavone
  • HY-138543
    NITD-688
    		Inhibitor 99.00%
    NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV).
    NITD-688
  • HY-143216A
    Ensitrelvir fumarate
    		Inhibitor 99.99%
    Ensitrelvir (S-217622) fumarate is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor (IC50=13 nM).
    Ensitrelvir fumarate
  • HY-10411
    AZ960
    		Inhibitor
    AZ960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM.
    AZ960
  • HY-14654S
    Aspirin-d3
    		Inhibitor 98.51%
    Aspirin-d3 is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL.
    Aspirin-d<sub>3</sub>
  • HY-N0470S3
    L-Lysine-13C6,15N2 hydrochloride
    		Inhibitor ≥98.0%
    L-Lysine-13C6,15N2 (hydrochloride) is the 13C- and 15N-labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine-<sup>13</sup>C<sub>6</sub>,<sup>15</sup>N<sub>2</sub> hydrochloride
  • HY-B1290
    2-Phenylethanol
    		Inhibitor 99.98%
    2-Phenylethanol (Phenethyl alcohol) is an aromatic alcohol with a rose-like odour. 2-Phenylethanol is a flavour and fragrance compound, and can be used as a preservative and anti-microbial agent. 2-Phenylethanol has antityrosinase and antimicrobial activities.
    2-Phenylethanol
  • HY-N0110B
    Palmatine hydroxide
    		Inhibitor 99.64%
    Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.
    Palmatine hydroxide
  • HY-100733
    4E2RCat
    		Inhibitor ≥98.0%
    4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
    4E2RCat
  • HY-E70370
    hrv 3c Protease
    hrv 3c Protease is a protease originated from human rhinoviruses. hrv 3c Protease recognizes the sequence LEVLFQGP and cleaves precisely between the Q and GP residues. hrv 3c Protease can be used to remove additional tags from the target proteins.
    hrv 3c Protease
Cat. No. Product Name / Synonyms Application Reactivity