2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Quinone Reductase

Quinone Reductase

Quinone Reductase

Quinones, a class of organic compounds, are formally derived from aromatic compounds and are a subset of the quinoid family which also contains the quinone imines and the quinone methides. NQO1 (QR1, EC 1.6.99.2), also referred to as DT-diaphorase (formerly), nicotinamide quinone oxidoreductase 1, quinone reductase type 1, or menadione reductase, is a cytosolic flavoenzyme. Another member of the quinone oxidoreductases family is NQO2 (QR2, EC 1.10.99.2) which is also a FAD bound protein (25 kDa) and closely related to NQO1. In addition to NQO1 and NQO2 found in humans, an ancient NQO3 subfamily exists in eubacteria, NQO4 subfamily in fungi, and NQO5 subfamily in archaebacteria[1][2].

Quinone Reductase Related Products (44):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-148480
    Nrf2 activator-6
    		Activator
    Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator. Nrf2 activator-6 has an IC50 of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4).
    Nrf2 activator-6
  • HY-115772
    4′-Bromoflavone
    		Inducer
    4′-Bromoflavone, a cancer chemopreventive agent, is a potent phase II detoxification enzymes inducer.
    4′-Bromoflavone
  • HY-118588
    Diminutol
    		Inhibitor 98.1%
    Diminutol is an inhibitor for NADP-dependent quinone oxidoreductase (NQO1), that is involved in microtubule morphogenesis and cell devision.
    Diminutol
  • HY-149244
    Nrf2 activator-7
    		Activator
    Nrf2 activator-7 (Compound 12b) is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway.
    Nrf2 activator-7
  • HY-170301
    Keap1-IN-1
    		Inhibitor
    Keap1-IN-1 (Compound 27) is the inhibitor for Keap1, that covalently modifys the Cys151 site in the BTB domain of KEAP1, and interfers with the interaction between Keap-Nrf. Keap1-IN-1 upregulates the mRNA expression of the antioxidant stress element (ARE)-dependent gene NQO1 with an EC50 of 160 nM. Keap1-IN-1 exhibits cytotoxicity in cell U2OS with an EC50 of 527 nM.
    Keap1-IN-1
  • HY-107736
    AI-3
    		Activator
    AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases.
    AI-3
  • HY-146114
    Antitumor agent-67
    		Substrate
    Antitumor agent-67 (compound 3) is a potent antitumor agent. Antitumor agent-67 has highly selective toxicity to cancer cells and lower damage to normal cells. Antitumor agent-67 can be activated by NQO1 and effectively liberate podophyllotoxin and kill tumor cells. Antitumor agent-67 significantly suppresses cancer growth in HepG2 xenograft models without obvious toxicity.
    Antitumor agent-67
  • HY-123903
    Tanshindiol B
    		Activator
    Tanshindiol B, a naphthaquinone diterpene, inhibits glioblastoma (GBM) growth by induction of noptosis (NQO1-dependent necrosis).
    Tanshindiol B
  • HY-171035
    PRL-295
    		Inhibitor
    PRL-295 is an orally active inhibitor targeting Keap1-Nrf2 interaction. PRL-295 increases the thermal stability of Keap1 and disrupts its interaction with Nrf2, thereby activating the Nrf2-dependent transcriptional target NAD(P)H:quinone oxidoreductase 1 (NQO1). PRL-295 protects against Acetaminophen (HY-66005)-induced liver injury in mice.
    PRL-295
  • HY-RS09523
    NQO1 Human Pre-designed siRNA Set A
    		Inhibitor

    NQO1 Human Pre-designed siRNA Set A contains three designed siRNAs for NQO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    NQO1 Human Pre-designed siRNA Set A
    NQO1 Human Pre-designed siRNA Set A
  • HY-121425
    Dunnione
    Dunnione (CompoundⅠ) is a pigment. Dunnione can be isolated from the leaves of Didymocarpus pedicellata.
    Dunnione
  • HY-N10344
    Glucoarabin
    		Activator
    Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity.
    Glucoarabin
  • HY-147795
    Nampt-IN-8
    		Substrate
    Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS.
    Nampt-IN-8
  • HY-141439
    TBE 31
    		Inducer
    TBE 31 is a potent and orally active NQO1 inducer with an Dm value of 1.1 nM. TBE 31 also is a potent Nrf2 activator. TBE 31 reacts with cysteines of Keap1, impairing its ability to target nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) for degradation. TBE 31 shows cytoprotective effects.
    TBE 31
  • HY-170947
    Antitumor agent-195
    		Inhibitor
    Antitumor agent-195 (compound 16c) is a dual targeting agent of STAT3 and NQO1. Antitumor agent-195 significantly inhibits phosphorylation of STAT3 at Tyr705 at a concentration of 1 μM and effectively induce Apoptosis in MDAMB-231 and MDA-MB-468 breast cancer cells. Antitumor agent-195 as a NQO1 substrate strongly increases ROS generation and causes severe DNA damage in a dose-dependent manner. Antitumor agent-195 shows encouraging anti-tumor efficacy in the MDA-MB-231 xenograft model.
    Antitumor agent-195
  • HY-N15190
    Sesaminol
    		Activator
    Sesaminol is an orally active activator for Nrf2-ARE pathway, that promotes the the nuclear translocation of Nrf2 and enhances the NQO1 expression, thereby enhances the cell's defense against oxidative stress. Sesaminol inhibits 6-OHDA (HY-B1081)-induced ROS production and apoptosis in cell SH-SY5Y. Sesaminol exhibits neuroprotective efficacy against Rotenone (HY-B1756)-induced Parkinson's disease.
    Sesaminol
  • HY-N15456
    Cryptolepinone
    		Activator
    Cryptolepinone is a quinone reductase activator with a CD (concentration required to double induction) value of 0.02 μg/mL and can be found in Sida acuta. In the mouse mammary organ culture assay, 10 μg/mL of Cryptolepinone inhibited 83.3% of the preneoplastic lesions induced by DMBA (HY-W011845). Cryptolepinone can be used in anti-cancer research.
    Cryptolepinone
  • HY-169842
    NSC 645827
    		Inhibitor
    NSC 645827 is an inhibitor for NAD(P)H: quinone oxidoreductase 1 (NQO1) with an IC50 of 0.7 μM.
    NSC 645827
  • HY-RS22982
    Nqo1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Nqo1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nqo1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Nqo1 Rat Pre-designed siRNA Set A
    Nqo1 Rat Pre-designed siRNA Set A
  • HY-RS16549
    Nqo1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Nqo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nqo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Nqo1 Mouse Pre-designed siRNA Set A
    Nqo1 Mouse Pre-designed siRNA Set A