2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Quinone Reductase
  5. Quinone Reductase Modulator

Quinone Reductase Modulator

Quinone Reductase Modulator (1):

Cat. No. Product Name Effect Purity
  • HY-128895A
    KL1333 hydrochloride
    		Modulator
    KL1333 hydrochloride is an orally active NAD+ modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD+ levels through NADH oxidation. Elevated NAD+ levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures.