2. Signaling Pathways
  3. Autophagy
    Neuronal Signaling
  4. PINK1/Parkin

PINK1/Parkin

PTEN-induced kinase 1/Parkin

PINK1 (PTEN-induced kinase 1) is a serine/threonine protein kinase whose activity is affected by mitochondrial membrane potential. PINK1 accumulates on the outer damaged mitochondrial membrane and activates PARKIN through phosphorylation. PARKIN is an E3 ubiquitin ligase that ubiquitinates mitochondrial outer membrane proteins, recruits autophagy-related proteins such as OPTN, NDP52, and initiates mitophagy. PINK1/Parkin regulates mitochondrial homeostasis, selectively removes damaged or redundant mitochondria, thereby maintaining and optimizing the mitochondrial network, regulating the energy metabolism, reducing oxidative stress and inflammatory responses. PINK1/Parkin dysfunction could lead to Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), or glaucoma[1][2].

PINK1/Parkin Related Products (27):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N13241
    Rhodiola Rosea Extract
    		Inhibitor
    Rhodiola Rosea Extract is a rhodiola rosea extract, and its components include: Salidroside. Rhodiola Rosea Extract can affect the release of stress hormones, promote energy metabolism, and can be used in the study of "stress" indications..
    Rhodiola Rosea Extract
  • HY-170992
    Autophagy agonist-1
    		Activator
    Autophagy agonist-1 (compound 22) is an Autophagy agonist. Autophagy agonist-1 exhibits significant anticancer activity against HepG2 cells and normal cells with IC50s of 8.8 μM and > 50 μM. Autophagy agonist-1 induces G1/S phase cell cycle arrest and inhibits CDK4 and CyclinD1 expression while upregulating P21. Autophagy agonist-1 promotes the accumulation of autophagosomes and the proteins LC3 and PINK1, enhancing autophagy and mitophagy in HepG2 cells.
    Autophagy agonist-1
  • HY-134398
    Kinetin triphosphate
    Kinetin triphosphate(6-Fu-ATP; KTP) is an ATP analogue that regulates or enhances kinase function with higher catalytic efficiency than its endogenous substrate, ATP. Kinetin triphosphate can be used in Parkinson's disease research.
    Kinetin triphosphate
  • HY-N0164R
    Matrine (Standard)
    Matrine (Standard) is the analytical standard of Matrine. This product is intended for research and analytical applications. Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI).
    Matrine (Standard)
  • HY-176568
    LCL768
    		Activator
    LCL768 is a ceramide analog. LCL768 attenuates PARKIN succination to promote PARKIN activation and mitophagy. LCL768 induces CerS1-mediated endogenous C18-ceramide accumulation in mitochondria to mediate mitophagy, which is dependent on DRP1 activation via nitrosylation at C644. LCL768 alters mitochondrial metabolism, resulting in fumarate depletion and leading to tumor suppression. LCL768 improves sensorimotor defects in neurodegenerative diseases like ALS.
    LCL768
  • HY-100410R
    FCCP (Standard)
    		Activator
    FCCP (Standard) is the analytical standard of FCCP. This product is intended for research and analytical applications. FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.
    FCCP (Standard)
  • HY-100941R
    CCCP (Standard)
    		Activator
    CCCP (Standard) is the analytical standard of CCCP. This product is intended for research and analytical applications. CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.
    CCCP (Standard)