2. Autophagy Neuronal Signaling Metabolic Enzyme/Protease
  3. Mitophagy PINK1/Parkin Mitochondrial Metabolism
  4. LCL768

LCL768 is a ceramide analog. LCL768 attenuates PARKIN succination to promote PARKIN activation and mitophagy. LCL768 induces CerS1-mediated endogenous C18-ceramide accumulation in mitochondria to mediate mitophagy, which is dependent on DRP1 activation via nitrosylation at C644. LCL768 alters mitochondrial metabolism, resulting in fumarate depletion and leading to tumor suppression. LCL768 improves sensorimotor defects in neurodegenerative diseases like ALS.

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LCL768 Chemical Structure

LCL768 Chemical Structure

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Description

LCL768 is a ceramide analog. LCL768 attenuates PARKIN succination to promote PARKIN activation and mitophagy. LCL768 induces CerS1-mediated endogenous C18-ceramide accumulation in mitochondria to mediate mitophagy, which is dependent on DRP1 activation via nitrosylation at C644. LCL768 alters mitochondrial metabolism, resulting in fumarate depletion and leading to tumor suppression. LCL768 improves sensorimotor defects in neurodegenerative diseases like ALS[1][2].

Molecular Weight

651.42

Formula

C37H67N2O3.1/2SeO3
SMILES

OC[C@H](NC(CCCCCCCCCCCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCC[N+]1=CC=CC=C1.[O-][Se]([O-])=O.[1/2]
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Room temperature in continental US; may vary elsewhere.
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LCL768 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LCL768LCL 768LCL-768MitophagyPINK1/ParkinMitochondrial MetabolismMitochondrial AutophagyPTEN-induced kinase 1/ParkinCeramideALSfumarate depletiontumorInhibitorinhibitorinhibit

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