2. Signaling Pathways
  3. Autophagy
    Neuronal Signaling
  4. PINK1/Parkin
  5. PINK1/Parkin Inhibitor

PINK1/Parkin Inhibitor

PINK1/Parkin Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-15887
    MG 149
    		Inhibitor 99.24%
    MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50 = 47 uM); little potent for PCAF and p300 (IC50 >200 uM). MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG 149 can induce mitochondrial depolarization and promote PINK1 dependent mitochondrial clearance. MG 149 can reverse chronic restraint stress (CRS) induced hypertension and related molecular changes. MG 149 commonly used in research on diseases such as hypertension and Parkinson's disease.
  • HY-163562
    JYQ-164
    		Inhibitor 99.43%
    JYQ-164 is a small molecule inhibitor of Parkinson's disease protein 7 (PARK7/DJ-1) in humans. JYQ-164 works by covalently and selectively targeting Cys106, a key residue of PARK7 (IC50=21 nM). The high inhibitory effect of JYQ-164 on PARK7 is 5 times more potent than the previously reported inhibitor JYQ-88. JYQ-164 can be used in Parkinson's disease and cancer research.
  • HY-N13241
    Rhodiola Rosea Extract
    		Inhibitor
    Rhodiola Rosea Extract is a rhodiola rosea extract, and its components include: Salidroside. Rhodiola Rosea Extract can affect the release of stress hormones, promote energy metabolism, and can be used in the study of "stress" indications..