2. Autophagy Neuronal Signaling
  3. PINK1/Parkin
  4. JYQ-164

JYQ-164 is a small molecule inhibitor of Parkinson's disease protein 7 (PARK7/DJ-1) in humans. JYQ-164 works by covalently and selectively targeting Cys106, a key residue of PARK7 (IC50=21 nM). The high inhibitory effect of JYQ-164 on PARK7 is 5 times more potent than the previously reported inhibitor JYQ-88. JYQ-164 can be used in Parkinson's disease and cancer research.

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JYQ-164 Chemical Structure

JYQ-164 Chemical Structure

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Based on 1 publication(s) in Google Scholar

JYQ-164 Related Antibodies

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Description

JYQ-164 is a small molecule inhibitor of Parkinson's disease protein 7 (PARK7/DJ-1) in humans. JYQ-164 works by covalently and selectively targeting Cys106, a key residue of PARK7 (IC50=21 nM). The high inhibitory effect of JYQ-164 on PARK7 is 5 times more potent than the previously reported inhibitor JYQ-88. JYQ-164 can be used in Parkinson's disease and cancer research[1].

IC50 & Target

PARK7

21 nM (IC50)

Molecular Weight

530.62

Formula

C23H26N6O5S2
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1CN(C#N)CC1)NC(S2)=NC3=C2CN(C(C4=CC=CC(S(=O)(N5CCOCC5)=O)=C4)=O)CC3
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (94.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8846 mL 9.4229 mL 18.8459 mL
5 mM 0.3769 mL 1.8846 mL 3.7692 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8846 mL 9.4229 mL 18.8459 mL 47.1147 mL
5 mM 0.3769 mL 1.8846 mL 3.7692 mL 9.4229 mL
10 mM 0.1885 mL 0.9423 mL 1.8846 mL 4.7115 mL
15 mM 0.1256 mL 0.6282 mL 1.2564 mL 3.1410 mL
20 mM 0.0942 mL 0.4711 mL 0.9423 mL 2.3557 mL
25 mM 0.0754 mL 0.3769 mL 0.7538 mL 1.8846 mL
30 mM 0.0628 mL 0.3141 mL 0.6282 mL 1.5705 mL
40 mM 0.0471 mL 0.2356 mL 0.4711 mL 1.1779 mL
50 mM 0.0377 mL 0.1885 mL 0.3769 mL 0.9423 mL
60 mM 0.0314 mL 0.1570 mL 0.3141 mL 0.7852 mL
80 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.5889 mL
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JYQ-164 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JYQ-164JYQ164JYQ 164PINK1/ParkinPTEN-induced kinase 1/ParkinCovalent bindingTargeted selectionPara-cancerNeurodegenerative diseasesInhibitorinhibitorinhibit

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