2. Signaling Pathways
  3. PI3K/Akt/mTOR
  4. mTOR
  5. mTOR Activator

mTOR Activator

mTOR Isoform Comparison

mTOR Activators (35):

Cat. No. Product Name Effect Purity
  • HY-B0795
    MHY1485
    		Activator 99.93%
    MHY1485 is a potent cell-permeable mTOR activator that targets the ATP domain of mTOR. MHY1485 inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.
  • HY-N0109
    Salidroside
    		Activator 99.90%
    Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.
  • HY-Y0252
    L-Proline
    		Activator ≥98.0%
    L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
  • HY-N0486
    L-Leucine
    		Activator 99.79%
    L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
  • HY-U00434
    3BDO
    		Activator 99.93%
    3BDO is a new mTOR activator which can also inhibit autophagy.
  • HY-114384
    NV-5138
    		Activator ≥98.0%
    NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 is used for antidepressant studies.
  • HY-114384B
    NV-5138 hydrochloride
    		Activator ≥98.0%
    NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride is used for antidepressant studies.
  • HY-N0486S9
    L-Leucine-d3
    		Activator 99.93%
    L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
  • HY-N0486S1
    L-Leucine-13C
    		Activator 99.4%
    L-Leucine-13C is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
  • HY-D0195
    Acesulfame potassium
    		Activator 99.38%
    Acesulfame potassium is a synthetic sweetener. Long-term use of Acesulfame potassium can affect cognitive function, possibly by altering the neurometabolic functions in mice. Acesulfame potassium can suppress autophagic degradation of PD-L1 in RIL-175 and SK-Hep1 cells through the ERK1/2-mTORC1-ULK1 pathway, which may be related to immune evasion in cancer cells. Acesulfame potassium can be used in research on neurological diseases, metabolic disorders, cancer, and immune evasion.
  • HY-134508
    C24-Ceramide
    		Activator 99.92%
    C24-Ceramide is an orally active competitive binding agonist of PIP4K2C (mTOR complex regulator), thereby activating the mTOR signaling pathway. At the same time, C24-Ceramide changes the membrane morphology by inducing the formation of a partially interlocked gel phase in the phospholipid bilayer. C24-Ceramide can promote the proliferation and migration of keratinocytes to accelerate skin wound healing and drive the proliferation and metastasis of gallbladder cancer cells. The level of C24-Ceramide in serum can be used as a diagnostic marker for gallbladder cancer.
  • HY-N0486S8
    L-Leucine-13C6,15N
    		Activator 99.90%
    L-Leucine-13C6,15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
  • HY-W130610
    Stearamide
    		Activator
    Stearamide is a primary fatty acid amide. Stearamide displays cytotoxic and ichthytoxic activity.
  • HY-N0486S2
    L-Leucine-13C6
    		Activator ≥98.0%
    Leucine-13C6 is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
  • HY-N0486S3
    L-Leucine-15N
    		Activator ≥98.0%
    L-Leucine-15N is the 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
  • HY-B0168B
    Levomilnacipran hydrochloride
    		Activator 99.95%
    Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC50 values of 10.5 nM and 19.0 nM, and Ki values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression.
  • HY-N0486S
    L-Leucine-d10
    		Activator ≥99.0%
    L-Leucine-d10 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
  • HY-Y0252R
    L-Proline (Standard)
    		Activator
    L-Proline (Standard) is the analytical standard of L-Proline. This product is intended for research and analytical applications. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
  • HY-N0486R
    L-Leucine (Standard)
    		Activator
    L-Leucine (Standard) is the analytical standard of L-Leucine. This product is intended for research and analytical applications. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
  • HY-124582
    NEO214
    		Activator ≥98.0%
    NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram (HY-16900) and perillyl alcohol (HY-N7000). It has anti-cancer activity and blood-brain barrier (BBB) permeability. Over sex. NEO214 prevents autophagy-lysosome fusion, thereby blocking autophagic flux and triggering glioma cell death. The process involves mTOR activation, andTFEB(Transcription Factor EB) aggregation. NEO214 inhibitionMacroautophagy/autophagy in glioblastoma cells has the potential to overcome chemotherapy resistance in glioblastoma.