2. Signaling Pathways
  3. Immunology/Inflammation
  4. LAG-3

LAG-3

Lymphocyte activation gene-3; CD223

Lymphocyte activation gene-3 (LAG-3) is an immune checkpoint protein that belongs to the immunoglobulin superfamily. LAG-3 is mainly expressed on activated T cells, NK cells, B cells and plasmacytoid dendritic cells. LAG-3 has a high affinity for MHC class II molecules and can also bind to FGL1. Binding of LAG-3 to its ligands leads to the inhibition of T cell activation and proliferation, thereby regulating the immune response. In the tumor microenvironment, overexpression of LAG-3 is often observed, which helps tumor cells escape immune surveillance. LAG-3 is considered as an important target for cancer immunotherapy. In addition to its role in tumor immunity, LAG-3 is also involved in the pathogenesis of some autoimmune diseases and infectious diseases[1][2][3].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P990912
    Cugrastomig
    HY-P990912 is an PDCD1/LAG3-targeting IgG1κ-[scFv-heavy -κ]2 type chimeric human and humanized antibody.
    Cugrastomig
  • HY-P990976
    Brivestobart
    HY-P990976 is an LAG3-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Brivestobart
  • HY-P10837
    LAG-3 cyclic peptide inhibitor 12
    		Inhibitor
    LAG-3 cyclic peptide inhibitor 12 (Cyclic peptide 12) is an inhibitor of LAG-3 with an IC50 value of 4.45 μM and a Ki value of 2.66 µM.
    LAG-3 cyclic peptide inhibitor 12
  • HY-P991298
    DNV-3
    		Inhibitor
    DNV-3 is a human monoclonal antibody (mAb) targeting CD223/LAG3.
    DNV-3
  • HY-P10835
    LAG-3 cyclic peptide inhibitor C25
    		Inhibitor
    LAG-3 cyclic peptide inhibitor C25 is a LAG-3 inhibitor. LAG-3 cyclic peptide inhibitor C25 has a high affinity with human LAG-3 protein with a Kd value of 0.66 μM. LAG-3 cyclic peptide inhibitor C25 can block the interaction of LAG-3 with HLA-DR (MHC-II) and activate CD8+ T cells. LAG-3 cyclic peptide inhibitor C25 can be used in the study of cancer.
    LAG-3 cyclic peptide inhibitor C25
  • HY-176814
    LAG-3-IN-1
    		Inhibitor
    LAG-3-IN-1 (Compound 11) is a LAG-3 inhibitor with a KD of 0.41  μM. LAG-3-IN-1 disrupts the LAG-3/MHCII interaction, enhances IFN-γ secretion and promotes tumor cell killing in cocultures of PBMCs and cancer cells. LAG-3-IN-1 can be used for cancers like ovarian cancer, colon adenocarcinoma and melanoma research.
    LAG-3-IN-1
  • HY-P990243
    Anti-Mouse FGL-1 Antibody (177R4)
    		Ligand
    Anti-Mouse FGL-1 Antibody (177R4) is an anti-mouse FGL-1 IgG2a monoclonal antibody. Anti-Mouse FGL-1 Antibody (177R4) can increase CD8+ T cell infiltration. Anti-Mouse FGL-1 Antibody (177R4) enhances the anti-tumor immune effect by blocking FGL1. Anti-Mouse FGL-1 Antibody (177R4) can be used for research on cancer such as lung cancer and breast cancer.
    Anti-Mouse FGL-1 Antibody (177R4)
  • HY-P990204
    Anti-Mouse LAG-3 (D265A) Antibody (C9B7W)
    		Inhibitor
    Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) is an anti-mouse LAG-3 IgG1 monoclonal antibody. Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) is a chimeric antibody of the original C9B7W antibody (HY-P99141). Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) contains the D265A mutation region. Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) can be used for research on cancer.
    Anti-Mouse LAG-3 (D265A) Antibody (C9B7W)
  • HY-P991303
    TQB-2223
    		Inhibitor
    TQB-2223 is a human monoclonal antibody (mAb) targeting CD223/LAG3. TQB-2223 can be used in the study of Hodgkin lymphoma.
    TQB-2223
  • HY-P991605
    HLX26
    		Inhibitor
    HLX26 is a humanised anti-LAG-3 monoclonal antibody. HLX26 has antitumor activity especially advanced solid tumours. HLX26 can be used for lymphoma research.
    HLX26
  • HY-176813
    LAG-3 Hit II
    		Inhibitor
    LAG-3 Hit II is a LAG-3 inhibitor with a KD of 4.32  μM. LAG-3 Hit II can be used for cancers like ovarian cancer, colon adenocarcinoma and melanoma research.
    LAG-3 Hit II
  • HY-P990750
    Negalstobart
    Negalstobart is an anti-LAG3 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Negalstobart
  • HY-P991299
    ENUM006
    		Inhibitor
    ENUM006 is a human monoclonal antibody (mAb) targeting CD223/LAG3.
    ENUM006
  • HY-164308
    SA-15-P
    		Inhibitor
    SA-15-P inhibits LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 values of 4.21 and 6.52 μM respectively. LAG-3/MHCII interaction is a target for immunotherapies.
    SA-15-P
Cat. No. Product Name / Synonyms Application Reactivity