2. Signaling Pathways
  3. Immunology/Inflammation
  4. LAG-3

LAG-3

Lymphocyte activation gene-3; CD223

Lymphocyte activation gene-3 (LAG-3) is an immune checkpoint protein that belongs to the immunoglobulin superfamily. LAG-3 is mainly expressed on activated T cells, NK cells, B cells and plasmacytoid dendritic cells. LAG-3 has a high affinity for MHC class II molecules and can also bind to FGL1. Binding of LAG-3 to its ligands leads to the inhibition of T cell activation and proliferation, thereby regulating the immune response. In the tumor microenvironment, overexpression of LAG-3 is often observed, which helps tumor cells escape immune surveillance. LAG-3 is considered as an important target for cancer immunotherapy. In addition to its role in tumor immunity, LAG-3 is also involved in the pathogenesis of some autoimmune diseases and infectious diseases[1][2][3].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P10835
    LAG-3 cyclic peptide inhibitor C25
    		Inhibitor
    LAG-3 cyclic peptide inhibitor C25 is a LAG-3 inhibitor. LAG-3 cyclic peptide inhibitor C25 has a high affinity with human LAG-3 protein with a Kd value of 0.66 μM. LAG-3 cyclic peptide inhibitor C25 can block the interaction of LAG-3 with HLA-DR (MHC-II) and activate CD8+ T cells. LAG-3 cyclic peptide inhibitor C25 can be used in the study of cancer.
    LAG-3 cyclic peptide inhibitor C25
  • HY-P99736
    Miptenalimab
    Miptenalimab (BI-754111) is an anti-human LAG-3 antibody (KD: 88.6 nM for h LAG-3). Miptenalimab blocks the interaction of LAG-3 with its ligand MHC-II.
    Miptenalimab
  • HY-P990740
    Fanastomig
    Fanastomig is an anti-PDCD1/LAG3 monoclonal antibody.
    Fanastomig
  • HY-P990204
    Anti-Mouse LAG-3 (D265A) Antibody (C9B7W)
    		Inhibitor
    Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse LAG-3.
    Anti-Mouse LAG-3 (D265A) Antibody (C9B7W)
  • HY-P990700
    Tobemstomig
    Tobemstomig is an anti-PDCD1/LAG3 human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
    Tobemstomig
  • HY-P991301
    IMP-761
    		Inhibitor
    IMP-761 is a human IgG4 monoclonal antibody (mAb) targeting CD223/LAG3. IMP-761 binds to D1 of human LAG32. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).
    IMP-761
  • HY-P990750
    Negalstobart
    Negalstobart is an anti-LAG3 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Negalstobart
  • HY-P991299
    ENUM006
    		Inhibitor
    ENUM006 is a human monoclonal antibody (mAb) targeting CD223/LAG3.
    ENUM006
  • HY-164308
    SA-15-P
    		Inhibitor
    SA-15-P inhibits LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 values of 4.21 and 6.52 μM respectively. LAG-3/MHCII interaction is a target for immunotherapies.
    SA-15-P
Cat. No. Product Name / Synonyms Application Reactivity