LAG-3 Inhibitor

LAG-3 Inhibitors (19):

Cat. No.	Product Name	Effect	Purity

HY-144987

RBN013209	Inhibitor	98.63%
RBN013209 is an orally active small molecule inhibitor of CD38 with an IC₅₀ of 0.01 to 0.1 μM for human CD38. RBN013209 prevents the conversion of extracellular NAD⁺ to ADPR or cADPR in tumor cells and PBMCs. RBN013209 can be used in the study of tumor. In addition, RBN013209 enables CAR-T cells to maintain the naive state and central memory state, and decreases the expression of cell activation markers and exhaustion-related inhibitory receptors.

HY-108691

PF-06465469	Inhibitor	99.48%
PF-06465469 is a covalent inhibitor of ITK with an IC₅₀ of 2 nM. PF-06465469 also inhibits BTK. PF-06465469 inhibits cell migration in response to CXCL12. PF-06465469 decreases PD-1 and LAG-3 expression. PF-06465469 can be used to study leukemia and T-cell lymphoma.

HY-P99141

Anti-Mouse LAG-3 Antibody (C9B7W)	Inhibitor
Anti-Mouse LAG-3 Antibody (C9B7W) is an anti-mouse LAG-3 IgG1 monoclonal antibody. Anti-Mouse LAG-3 Antibody (C9B7W) can enhance CD4⁺ T cell function and exert anti-tumor effects without blocking the interaction between LAG-3 and MHCII. Anti-Mouse LAG-3 Antibody (C9B7W) can be used for research on cancer such as head and neck squamous cell carcinoma (HNSCC).

HY-P991300

GSK2831781	Inhibitor
GSK2831781 is a human IgG1 monoclonal antibody (mAb) targeting CD223/LAG3. GSK2831781 can be used in the study of ulcerative colitis Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991302

KL-A289	Inhibitor
KL-A289 is a human monoclonal antibody (mAb) targeting CD223/LAG3. KL-A289 can be used in the study of metastatic GC.

HY-P991297

AM0003	Inhibitor
AM0003 is a human monoclonal antibody (mAb) targeting CD223/LAG3. AM0003 can be used in the study of advanced solid tumors.

HY-P99922

Encelimab	Inhibitor
Encelimab is an anti-LAG3 antibody. Encelimab blocks the interaction between LAG-3 and MHC II, and enhances T-cell activation. Encelimab alone or in combination with an anti-PD-1 antibody reduces tumor size in a lymphoma mice model (A20 cell xenograft).

HY-P991301

IMP-761	Inhibitor
IMP-761 is a human IgG4 monoclonal antibody (mAb) targeting CD223/LAG3. IMP-761 binds to D1 of human LAG32. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).

HY-P10837

LAG-3 cyclic peptide inhibitor 12	Inhibitor
LAG-3 cyclic peptide inhibitor 12 (Cyclic peptide 12) is an inhibitor of LAG-3 with an IC₅₀ value of 4.45 μM and a K_i value of 2.66 µM.

HY-P991298

DNV-3	Inhibitor
DNV-3 is a human monoclonal antibody (mAb) targeting CD223/LAG3.

HY-P10835

LAG-3 cyclic peptide inhibitor C25	Inhibitor
LAG-3 cyclic peptide inhibitor C25 is a LAG-3 inhibitor. LAG-3 cyclic peptide inhibitor C25 has a high affinity with human LAG-3 protein with a K_d value of 0.66 μM. LAG-3 cyclic peptide inhibitor C25 can block the interaction of LAG-3 with HLA-DR (MHC-II) and activate CD8⁺ T cells. LAG-3 cyclic peptide inhibitor C25 can be used in the study of cancer.

HY-176814

LAG-3-IN-1	Inhibitor
LAG-3-IN-1 (Compound 11) is a LAG-3 inhibitor with a K_D of 0.41  μM. LAG-3-IN-1 disrupts the LAG-3/MHCII interaction, enhances IFN-γ secretion and promotes tumor cell killing in cocultures of PBMCs and cancer cells. LAG-3-IN-1 can be used for cancers like ovarian cancer, colon adenocarcinoma and melanoma research.

HY-P990204

Anti-Mouse LAG-3 (D265A) Antibody (C9B7W)	Inhibitor
Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) is an anti-mouse LAG-3 IgG1 monoclonal antibody. Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) is a chimeric antibody of the original C9B7W antibody (HY-P99141). Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) contains the D265A mutation region. Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) can be used for research on cancer.

HY-178320

LAG-3-IN-2	Inhibitor
LAG-3-IN-2 (Compound LG-17) is a LAG-3 inhibitor. LAG-3-IN-2 can be used for the study of immunology.

HY-P991303

TQB-2223	Inhibitor
TQB-2223 is a human monoclonal antibody (mAb) targeting CD223/LAG3. TQB-2223 can be used in the study of Hodgkin lymphoma.

HY-P991605

HLX26	Inhibitor
HLX26 is a humanised anti-LAG-3 monoclonal antibody. HLX26 has antitumor activity especially advanced solid tumours. HLX26 can be used for lymphoma research.

HY-176813

LAG-3 Hit II	Inhibitor
LAG-3 Hit II is a LAG-3 inhibitor with a K_D of 4.32  μM. LAG-3 Hit II can be used for cancers like ovarian cancer, colon adenocarcinoma and melanoma research.

HY-P991299

ENUM006	Inhibitor
ENUM006 is a human monoclonal antibody (mAb) targeting CD223/LAG3.

HY-164308

SA-15-P	Inhibitor
SA-15-P inhibits LAG-3/MHCII and LAG-3/FGL1 interactions with IC₅₀ values of 4.21 and 6.52 μM respectively. LAG-3/MHCII interaction is a target for immunotherapies.

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