2. Signaling Pathways
  3. Immunology/Inflammation
  4. Fc Receptor (FcR)
  5. Fc Receptor (FcR) Inhibitor

Fc Receptor (FcR) Inhibitor

Fc Receptor (FcR) Inhibitors (7):

Cat. No. Product Name Effect Purity
  • HY-P99009
    Batoclimab
    		Inhibitor 99.89%
    Batoclimab (RVT-1401) is a fully humanized IgG1 monoclonal antibody targeting FcRn. Batoclimab has high affinity for the IgG-binding site on FcRn. By competitively binding to the IgG binding site on FcRn, Batoclimab blocks FcRn-mediated recycling of IgG, resulting in enhanced degradation and subsequent reductions in IgG levels. Batoclimab can be used in the research of autoimmune diseases such as myasthenia gravis and thyroid eye disease.
  • HY-P990676
    VIB-9600
    		Inhibitor 99.41%
    VIB-9600 is a humanized antibody expressed in CHO cells, targeting FcgR2a/CD32a. VIB-9600 has a huIgG1 type heavy chain and huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for VIB-9600 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
  • HY-P991086
    MGD010
    		Inhibitor
    MGD010 is a bispecific CD32B (FcγRIIb) and CD79B antibody. MGD010 inhibits activated B-cells by delivering a negative signal via simultaneous co-ligation of CD32B (FcγRIIb), with the BCR component, CD79B. MGD010 has the potential for the study of autoimmune disorders.
  • HY-P990413
    Anti-Fc gamma R1 Antibody
    		Inhibitor
    The Anti-Fc gamma R1 Antibody is a human-derived antibody expressed in CHO, targeting Fc gamma R1. The Anti-Fc gamma R1 Antibody features a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For the isotype control of the Anti-Fc gamma R1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
  • HY-145775
    hIgG-hFc receptor-IN-1
    		Inhibitor
    hIgG–hFc receptor-IN-1 (comp 66) is a human immunoglobulin G–human neonatal Fc receptor (hIgG–hFcRn) protein-protein interaction inhibitor, with an IC50 of 2 μM .
  • HY-158316
    BTL-MK
    		Inhibitor
    BTL-MK (Compound 19) an orally active antiallergic agent, that inhibits degranulation of mast cells with an IC50 of 6.7 μM, through binding to the inhibitory receptor FcγRIIB. BTL-MK improves the metaboilic stability in human liver microsomes. BTL-MK ameliorates the allergic response in Ovalbumins (HY-W250978)-induced food allergy mice model. BTL-MK exhibits a good pharmacokinetic character with metabolic stability.
  • HY-P990244
    Anti-Rat FcRn heavy chain heterodimers Antibody (2G3)
    		Inhibitor
    Anti-Rat FcRn heavy chain heterodimers Antibody (2G3) is a mouse-derived IgG1 type antibody inhibitor, targeting to rat FcRn heavy chain heterodimers.