2. Signaling Pathways
  3. Immunology/Inflammation
  4. Fc Receptor (FcR)

Fc Receptor (FcR)

Fc Receptor

Fc Receptors (FcR) are a class of cell surface receptors that can recognize and bind to the Fc region of immunoglobulins, playing an important role in processes such as the immune response and immune regulation. According to the types of immunoglobulins they recognize, FcR can be classified into FcγR, FcεR, FcαR, etc. According to their functional characteristics, they can be divided into activating FcR and inhibitory FcR. FcR mediate the phagocytosis of immune cells, prompting phagocytes to eliminate antigenic foreign substances such as pathogens. FcR also participate in ADCC, which activates NK cells and other cells to kill target cells, affecting the immune response. In addition, FcR can clear immune complexes and prevent them from depositing in tissues and triggering inflammation. Abnormal functions or dysregulated expressions of FcR can lead to autoimmune diseases and allergic diseases. In tumors, FcR are involved in both the immune escape of tumor cells and can serve as targets for immunotherapy[1][2].

Fc Receptor (FcR) Related Products (38):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-NP193B
    Rat IgG Fab fragment
    Rat IgG Fab fragment is a fragment of antigen (Fab) of rat immunoglobulin G (IgG) molecules that can be used as an immunolabel in various immunoassays, including ELISA.
    Rat IgG Fab fragment
  • HY-NP0197
    Goat immunoglobulin G
    Goat Immunoglobulin G (Goat IgG) is a goat serum immunoglobulin that can be used in immunolabeling and coating protein in a variety of immunoassays including ELISA.
    Goat immunoglobulin G
  • HY-145775
    hIgG-hFc receptor-IN-1
    		Inhibitor
    hIgG–hFc receptor-IN-1 (comp 66) is a human immunoglobulin G–human neonatal Fc receptor (hIgG–hFcRn) protein-protein interaction inhibitor, with an IC50 of 2 μM .
    hIgG-hFc receptor-IN-1
  • HY-158316
    BTL-MK
    		Inhibitor
    BTL-MK (Compound 19) an orally active antiallergic agent, that inhibits degranulation of mast cells with an IC50 of 6.7 μM, through binding to the inhibitory receptor FcγRIIB. BTL-MK improves the metaboilic stability in human liver microsomes. BTL-MK ameliorates the allergic response in Ovalbumins (HY-W250978)-induced food allergy mice model. BTL-MK exhibits a good pharmacokinetic character with metabolic stability.
    BTL-MK
  • HY-NP193A
    Rat IgG Fc fragment
    Rat IgG Fc fragment is a crystallizable fragment (Fc) of rat immunoglobulin G (IgG) molecules that can be used as an immunolabel in various immunoassays, including ELISA.
    Rat IgG Fc fragment
  • HY-NP0196E
    Mouse IgG Fab fragment
    Mouse IgG Fab fragment is a fragment of antigen (Fab) of mouse immunoglobulin G (IgG) molecules that can be used as an immunolabel in various immunoassays, including ELISA.
    Mouse IgG Fab fragment
  • HY-P991582
    BI-1607
    		Antagonist
    BI-1607 is a humanized monoclonal antibody targeting CD32b/FcγRIIB. BI-1607 has an antagonistic function capable of blocking the inhibitory function of FcγRIIB on immune effector cells. BI-1607 has a significant cytolytic activity against malignant B cells and antitumor activity against HER2-positive solid tumors including advanced gastric cancer (GC) with combination with Trastuzumab (HY-P9907).
    BI-1607
  • HY-NP0197A
    Goat IgG Fc fragment
    Goat IgG Fc fragment is a crystallizable fragment (Fc) of goat immunoglobulin G (IgG) molecules that can be used as an immunolabel in various immunoassays, including ELISA.
    Goat IgG Fc fragment
  • HY-P991705
    Nebaprubart
    		Inhibitor
    Nebaprubart is a humanized IgG4κ antibody targeting FCAR/CD89. The corresponding isotype control is: Human IgG4 kappa, Isotype Control (HY-P99003).
    Nebaprubart
  • HY-P991043
    Syrian Hamster IgG, Isotype Control
    Syrian Hamster IgG, Isotype Control is the syrian hamster antibody that is the isotype control of Syrian Hamster IgG antibody.
    Syrian Hamster IgG, Isotype Control
  • HY-P990291
    Anti-Mouse CD16.2 Antibody (9E9)
    		Inhibitor
    Anti-Mouse CD16.2 Antibody (9E9) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse CD16.2. Anti-Mouse CD16.2 Antibody (9E9) reacts with mouse CD16.2, also known as FcγRIV (Fc receptor, IgG, low affinity IV). Anti-Mouse CD16.2 Antibody (9E9) inhibits cellular CD16.2 expression and signaling and blocks FcγRIV. Anti-Mouse CD16.2 Antibody (9E9) can be used for the researches of cancer, inflammation and immunology, such as CT26 tumor and lung inflammation.
    Anti-Mouse CD16.2 Antibody (9E9)
  • HY-NP0197B
    Goat IgG Fab fragment
    Goat IgG Fab fragment is a fragment of antigen (Fab) of goat immunoglobulin G (IgG) molecules that can be used as an immunolabel in various immunoassays, including ELISA.
    Goat IgG Fab fragment
  • HY-P991476
    MDX-220
    		Antagonist
    MDX-220 is a human monoclonal antibody (mAb) targeting FcRn. MDX-220 has anti-tumor activity.
    MDX-220
  • HY-P990244
    Anti-Rat FcRn heavy chain heterodimers Antibody (2G3)
    		Inhibitor
    Anti-Rat FcRn heavy chain heterodimers Antibody (2G3) is an anti-rat FcRn heavy chain heterodimers IgG1 monoclonal antibody. Anti-Rat FcRn heavy chain heterodimers Antibody (2G3) effectively inhibits the binding of FcRn to IgG. Anti-Rat FcRn heavy chain heterodimers Antibody (2G3) is used in studies of the MHC class I heavy chain FcRn heterodimers and their interaction with IgG.
    Anti-Rat FcRn heavy chain heterodimers Antibody (2G3)
  • HY-P991651
    MEDI4212
    		Inhibitor
    MEDI4212 is a humanized IgG1λ monoclonal antibody inhibitor targeting IgE. MEDI4212 potently inhibits human IgE-mediated functional responses through its receptor FcεRI, such as calcium signaling, β-hexosaminidase release and phagocytosis. MEDI4212 prevents the binding of IgE to CD23 with an IC50 of 8 nM. MEDI4212 can be used severe asthma research.
    MEDI4212
  • HY-P990290
    Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2)
    		Inhibitor
    Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD16/CD32. Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) is a chimeric antibody of the original 2.4G2 antibody (HY-P99125). Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) contains the LALA-PG mutation region. Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) can block the combination of CD16 and FcγRs. Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) can be used for the researches of immunology and cardiovascular disease.
    Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2)
  • HY-P991502
    Armenian hamster IgG1 kappa, Isotype Control
    Armenian hamster IgG1 kappa, Isotype Control, a Armenian hamster monoclonal antibody, is an isotype control for Armenian hamster IgG1 kappa antibody.
    Armenian hamster IgG1 kappa, Isotype Control
  • HY-P991225
    BI-1206
    		Antagonist
    BI-1206 is a recombinant and antagonistic human monoclonal antibody targeting FcγRIIB (CD32B). BI-1206 can block CD20 internalization induced by Rituximab (HY-P9913) itself or combined with others including Ibrutinib (HY-10997), Venetoclax (HY-15531), and CHOP. BI-1206 can enhance or recover the activity of Rituximab or other anti-CD20 monoclonal antibodies. BI-1206 has cytolytic activity against malignant B cells. BI-1206 can be studied for cancer research such as mantle cell lymphoma (MCL).
    BI-1206