2. Signaling Pathways
  3. Immunology/Inflammation
  4. Fc Receptor (FcR)
  5. Fc Receptor (FcR) Antagonist

Fc Receptor (FcR) Antagonist

Fc Receptor (FcR) Antagonists (3):

Cat. No. Product Name Effect Purity
  • HY-P991582
    BI-1607
    		Antagonist
    BI-1607 is a humanized monoclonal antibody targeting CD32b/FcγRIIB. BI-1607 has an antagonistic function capable of blocking the inhibitory function of FcγRIIB on immune effector cells. BI-1607 has a significant cytolytic activity against malignant B cells and antitumor activity against HER2-positive solid tumors including advanced gastric cancer (GC) with combination with Trastuzumab (HY-P9907).
  • HY-P991225
    BI-1206
    		Antagonist
    BI-1206 is a recombinant and antagonistic human monoclonal antibody targeting FcγRIIB (CD32B). BI-1206 can block CD20 internalization induced by Rituximab (HY-P9913) itself or combined with others including Ibrutinib (HY-10997), Venetoclax (HY-15531), and CHOP. BI-1206 can enhance or recover the activity of Rituximab or other anti-CD20 monoclonal antibodies. BI-1206 has cytolytic activity against malignant B cells. BI-1206 can be studied for cancer research such as mantle cell lymphoma (MCL).
  • HY-P991476
    MDX-220
    		Antagonist
    MDX-220 is a human monoclonal antibody (mAb) targeting FcRn. MDX-220 has anti-tumor activity.