2. Signaling Pathways
  3. Cytoskeleton
  4. Collagen
  5. Collagen Inhibitor

Collagen Inhibitor

Collagen Inhibitors (4):

Cat. No. Product Name Effect Purity
  • HY-108681
    680C91
    		Inhibitor 99.54%
    680C91 is an orally active, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with a Ki of 51 nM. TDO is the key enzyme of tryptophan catabolism. 680C91 can be used for the research of cancer immunotherapy and Alzheimer’s Disease.
  • HY-139589
    Zaloglanstat
    		Inhibitor 98.50%
    Zaloglanstat (ISC-27864; GRC-27864) is a selective, orally active microsomal mPGES-1 inhibitor. Zaloglanstat has an IC50 of 5 nM for human mPGES-1 without significant inhibitory effect on COX-1/2 (IC50 >10 μM). Zaloglanstat blocks the conversion of arachidonic acid metabolite prostaglandin PGH2 to prostaglandin PGE2, thereby inhibiting inflammation-related PGE2 overproduction and reducing inflammatory responses and pain. Zaloglanstat inhibits IL-1β-induced PGE2 release in A549 cells and human synovial fibroblasts in vitro. Zaloglanstat inhibits PGE2 release in pig and dog whole blood with IC50s ??of 161 nM and 154 nM, respectively. Zaloglanstat can be used in the study of asthma, osteoarthritis, and neurodegenerative diseases.
  • HY-127150
    Clofezone
    		Inhibitor
    Clofezone (Perclusone) is an antirheumatic agent that inhibits collagen formation in rat Chondrus granulomas. Clofezone can be used in the study of various rheumatic diseases, especially arthritis (RA) and ankylosing spondylitis (AS).
  • HY-W273690
    Pentifylline
    		Inhibitor 99.23%
    Pentifylline is a vasodilator with anti-inflammatory activity. Pentifylline inhibits platelet aggregation and thromboxane A2 synthesis, reduces the release of free radicals, and decreases the production of type 1 collagen and laminin in fibroblasts. Pentifylline has the potential to be studied in acute ischemic stroke.