2. Signaling Pathways
  3. Immunology/Inflammation
  4. CD3

CD3

Cluster of differentiation 3

CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P990608
    Alpitatug
    		99.13%
    Alpitatug (IMC 3C5) is a CHO-expressed human antibody that targets KLK2/Kallikrein 2. Alpitatug has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.3 kDa. The isotype control for Alpitatug can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Alpitatug
  • HY-P990717
    Brenetafusp
    		Inhibitor
    Brenetafusp is an anti-CD3E/PRAME monoclonal antibody.
    Brenetafusp
  • HY-P99146
    Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)
    		Inhibitor
    Anti-Mouse TCR gamma/delta Antibody is an anti-mouse TCR gamma/delta IgG antibody inhibitor derived from host Armenian Hamster.
    Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)
  • HY-P990095
    Vonsetamig
    		Inhibitor
    Vonsetamig is a humanised immunoglobulin G4-kappa, anti-TNFRSF17 and CD3E bispecific antibody. Vonsetamig is an antineoplastic.
    Vonsetamig
  • HY-P990920
    Gocatamig
    		Inhibitor ≥99.0%
    HY-P990920 is an CD3E/ALB/DLL3-targeting (scFv-heavy-lamdba)-VH-VH' type chimeric humanized antibody.
    Gocatamig
  • HY-P991088
    HPN536
    		Inhibitor
    HPN536 is a trispecific, T-cell-activating protein-based construct, which binds to mesothelin-expressing tumor cells, CD3ε on T cells, and to serum albumin. HPN536 specifically redirects T cells for potent redirected lysis of mesothelin-expressing cancer cells with concomitant T-cell activation.
    HPN536
  • HY-P99562
    Tidutamab
    Tidutamab (XmAb-18087) is a humanized and affinity-optimized bispecific antibody (bsAb) targeting SSTR2 binding domain and T-cell binding domain (CD3). Tidutamab possesses a full Fc domain to maintain long serum half-life.Tidutamab eliminates SSTR+ tumor cells by stimulating redirected T cellmediated cytotoxicity (RTcC).
    Tidutamab
  • HY-P990925
    Linclatamig
    		Inhibitor
    HY-P990925 is an CD3E-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
    Linclatamig
  • HY-P990903
    Avitotamig
    		Inhibitor
    HY-P990903 is an CD3E/CD33-targeting [H-γ1 _ L-κ-scFv heavy -κ]-dimer type bispecific antibody.
    Avitotamig
  • HY-P990955
    Ebribafusp alfa
    		Inhibitor
    HY-P990955 is an CD3E-targeting IgG4κ type chimeric antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Ebribafusp alfa
  • HY-P991015
    Pasritamig
    		Inhibitor
    HY-P991015 is an KLK2/CD3E-targeting (H-γ1_L-κ)_scFvkh-G1(h-CH2-CH3) type bispecific antibody.
    Pasritamig
  • HY-P990928
    Mipletamig
    		Inhibitor
    HY-P990928 is an CD3E-targeting [(scFv -κ-heavy) G1-h-CH2-CH3 (scFv-heavy -κ)]2 type chimeric human and humanized antibody.
    Mipletamig
  • HY-P990953
    Zubotamig
    		Inhibitor
    HY-P990953 is an CD3E/VTCN1-targeting Ig(G1 -κ_G1 -λ2) type chimeric human antibody.
    Zubotamig
  • HY-P990969
    Amtabafusp alfa
    		Inhibitor
    HY-P990969 is an CD3E/CD4-targeting IgG1 λ1 type humanized antibody, the recommed isotype control is Human IgG1 lambda1, Isotype Control (HY-P99992).
    Amtabafusp alfa
  • HY-P990862
    Anti-CD326/EpCAM Antibody (Ber-EP4)
    Anti-CD326/EpCAM Antibody (Ber-EP4) is a kind of mouse IgG1, κ chimeric antibody, targeting to human CD326/EpCAM. The recommend isotype control of Anti-CD326/EpCAM Antibody (Ber-EP4): Mouse IgG1 kappa, Isotype Control (HY-P99977).
    Anti-CD326/EpCAM Antibody (Ber-EP4)
  • HY-P991172
    JNJ-70218902
    JNJ-70218902 is a bispecific antibody that binds to human TMEFF2 on cancer cells and to human CD3 on T cells. JNJ-70218902 induces an exposure-dependent proinflammatory response and targeted tumor cell lysis, and promotes T cell-mediated tumor cell killing (EC50: 1.4 nM). JNJ-70218902 has a promising potential for prostate cancer research. The recommended isotype control is human IgG4 kappa, isotype control (HY-P99003).
    JNJ-70218902
  • HY-P991490
    ISB2001
    		Inhibitor
    ISB2001 is a human trispecific antibody (tsAb) targeting CD38 & CD3 & BCMA. BI-765423 can be used in relapsed/refractory multiple myeloma (RRMM) research. Recommended isotype control: IgG1-kappa-IgG1-Fab.
    ISB2001
  • HY-P991463
    MS133
    		Inhibitor
    MS133 is a human bispecific antibody (bsAb) targeting CD133/PROM1 & CD3E. MS133 can be used in colon cancer research.
    MS133
  • HY-N10446
    Maydispenoid B
    Maydispenoid B is a potent immunosuppressor. Maydispenoid B can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation.
    Maydispenoid B
  • HY-P990272
    Anti-Mouse CD3ε Antibody (KT3)
    		Inhibitor
    Anti-Mouse CD3ε Antibody (KT3) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse CD3ε.
    Anti-Mouse CD3ε Antibody (KT3)
Cat. No. Product Name / Synonyms Application Reactivity