2. Signaling Pathways
  3. Immunology/Inflammation
  4. CD3

CD3

Cluster of differentiation 3

CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P99146
    Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)
    		Inhibitor
    Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) is an anti-mouse TCR gamma/delta IgG monoclonal antibody. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can enter the blood-brain barrier. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) effectively depletes γδ T cells and reduces macrophage and neutrophil infiltration. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can reduce the immune response of transplants. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can be used for research on inflammation conditions, virus infection and cancer such as arthritis, JHM virus and breast cancer.
    Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)
  • HY-P990095
    Vonsetamig
    		Inhibitor
    Vonsetamig is a humanised immunoglobulin G4-kappa, anti-TNFRSF17 and CD3E bispecific antibody. Vonsetamig is an antineoplastic.
    Vonsetamig
  • HY-P990608
    Alpitatug
    		99.13%
    Alpitatug (IMC 3C5) is a CHO-expressed human antibody that targets KLK2/Kallikrein 2. Alpitatug has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.3 kDa. The isotype control for Alpitatug can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Alpitatug
  • HY-P99776
    Plamotamab
    		Inhibitor 99.12%
    Plamotamab (XmAb-13676) is a human bispecific antibody (bsAb) that binds CD3 and CD20. Plamotamab recruits cytotoxic T cells to kill CD20+ expressing tumor cells. Plamotamab induces a mild hematologic reaction (MR), and results in tumor regression in vivo.
    Plamotamab
  • HY-P990920
    Gocatamig
    		Inhibitor ≥99.0%
    HY-P990920 is an CD3E/ALB/DLL3-targeting (scFv-heavy-lamdba)-VH-VH' type chimeric humanized antibody.
    Gocatamig
  • HY-P990717
    Brenetafusp
    		Inhibitor
    Brenetafusp is an anti-CD3E/PRAME monoclonal antibody.
    Brenetafusp
  • HY-P990272
    Anti-Mouse CD3ε Antibody (KT3)
    		Inhibitor
    Anti-Mouse CD3ε Antibody (KT3) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse CD3ε. Anti-Mouse CD3ε Antibody (KT3) increases thymocytes proliferation. Anti-Mouse CD3ε Antibody (KT3) can be used for the research of immunology.
    Anti-Mouse CD3ε Antibody (KT3)
  • HY-P991088
    HPN536
    		Inhibitor
    HPN536 is a trispecific, T-cell-activating protein-based construct, which binds to mesothelin-expressing tumor cells, CD3ε on T cells, and to serum albumin. HPN536 specifically redirects T cells for potent redirected lysis of mesothelin-expressing cancer cells with concomitant T-cell activation.
    HPN536
  • HY-P991055
    Forimtamig
    		Inhibitor
    Forimtamig (RG-6324) is a GPRC5DxCD3 T-cell-engaging bispecific antibody. Forimtamig has a 2 + 1 format, comprising two high-affinity GPRC5D binding moieties and one CD3 binder. Forimtamig further features a P329G LALA mutated Fc domain that inhibits Fcγ receptor and C1q binding, yet retains binding to the neonatal Fc receptor. The isotype control for Forimtamig can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Forimtamig
  • HY-P990932
    Obrixtamig
    		Inhibitor
    HY-P990932 is an CD3E/DLL3-targeting L-κ-G1-h-CH2-CH3_L-λ-G1-h-CH2-CH3 type human antibodychimeric antibody.
    Obrixtamig
  • HY-P991015
    Pasritamig
    		Inhibitor
    HY-P991015 is an KLK2/CD3E-targeting (H-γ1_L-κ)_scFvkh-G1(h-CH2-CH3) type bispecific antibody.
    Pasritamig
  • HY-P991209
    Nebratamig
    		Inhibitor
    Nebratamig (GNC-035) is an anti-ROR1/anti-CD3/anti-PD-L1/anti-4-1BB tetra-specific antibody with potential immunostimulatory and antineoplastic activities.
    Nebratamig
  • HY-P991183
    SAR-442257
    		Inhibitor
    SAR442257 is a humanized IgG4-S228P, kappa monoclonal antibody targeting CD38 and CD28 on multiple myeloma cells and co-stimulates CD3 and CD28 on T cells.
    SAR-442257
  • HY-P99562
    Tidutamab
    		99.96%
    Tidutamab (XmAb-18087) is a humanized and affinity-optimized bispecific antibody (bsAb) targeting SSTR2 binding domain and T-cell binding domain (CD3). Tidutamab possesses a full Fc domain to maintain long serum half-life.Tidutamab eliminates SSTR+ tumor cells by stimulating redirected T cellmediated cytotoxicity (RTcC).
    Tidutamab
  • HY-P990925
    Linclatamig
    		Inhibitor
    HY-P990925 is an CD3E-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
    Linclatamig
  • HY-P990955
    Ebribafusp alfa
    		Inhibitor
    HY-P990955 is an CD3E-targeting IgG4κ type chimeric antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Ebribafusp alfa
  • HY-P990928
    Mipletamig
    		Inhibitor
    HY-P990928 is an CD3E-targeting [(scFv -κ-heavy) G1-h-CH2-CH3 (scFv-heavy -κ)]2 type chimeric human and humanized antibody.
    Mipletamig
  • HY-P990953
    Zubotamig
    		Inhibitor
    HY-P990953 is an CD3E/VTCN1-targeting Ig(G1 -κ_G1 -λ2) type chimeric human antibody.
    Zubotamig
  • HY-P990969
    Amtabafusp alfa
    		Inhibitor
    HY-P990969 is an CD3E/CD4-targeting IgG1 λ1 type humanized antibody, the recommed isotype control is Human IgG1 lambda1, Isotype Control (HY-P99992).
    Amtabafusp alfa
  • HY-P990862
    Anti-CD326/EpCAM Antibody (Ber-EP4)
    Anti-CD326/EpCAM Antibody (Ber-EP4) is a kind of mouse IgG1, κ chimeric antibody, targeting to human CD326/EpCAM. The recommend isotype control of Anti-CD326/EpCAM Antibody (Ber-EP4): Mouse IgG1 kappa, Isotype Control (HY-P99977).
    Anti-CD326/EpCAM Antibody (Ber-EP4)
Cat. No. Product Name / Synonyms Application Reactivity