2. Signaling Pathways
  3. Immunology/Inflammation
  4. C-type Lectin-like Receptors (CTLRs)

C-type Lectin-like Receptors (CTLRs)

C-type Lectin-like Receptors (CTLRs)

C-type Lectin-like Receptors (CTLRs) are a class of protein receptors that contain a C-type lectin-like domain but do not necessarily rely on calcium ions to recognize ligands. They are usually classified as activating or inhibitory receptors, based on their intracellular signaling motifs. CTLRs are capable of recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), and play important roles in innate and adaptive immunity. After binding to ligands, CLRs act as antigen-uptake receptors, internalize antigens and present them to T cells, and activate multiple signaling pathways such as NF-κB, IFN, and inflammasomes to regulate the functions of immune cells. Abnormal expression or function of CLRs is closely related to cancer, infectious diseases, autoimmune diseases, and others[1][2].

C-type Lectin-like Receptors (CTLRs) Related Products (25):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P990284
    Anti-Mouse CD205 Antibody (NLDC-145)
    Anti-Mouse CD205 Antibody (NLDC-145) is a rat-derived IgG2aκ type antibody inhibitor, targeting to mouse CD205. Anti-Mouse CD205 Antibody (NLDC-145) reacts with CD205 also known as DEC-205. Anti-Mouse CD205 Antibody (NLDC-145) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as colitis, D2F2/E2 tumor and diabetes.
    Anti-Mouse CD205 Antibody (NLDC-145)
  • HY-P990258
    Anti-Mouse CLEC9A/CD370 Antibody (7H11)
    		Inhibitor
    Anti-Mouse CLEC9A/CD370 Antibody (7H11) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse CLEC9A/CD370. Anti-Mouse CLEC9A/CD370 Antibody (7H11) reacts with mouse CLEC9A (C-type lectin domain family member 9A) and blocks CLEC9A. Anti-Mouse CLEC9A/CD370 Antibody (7H11) can be used for the researches of cancer and immunology, such as B16.F10-OVA tumor.
    Anti-Mouse CLEC9A/CD370 Antibody (7H11)
  • HY-P991309
    ZM-008
    		Inhibitor
    ZM-008 is a human monoclonal antibody (mAb) targeting OCIL/CLEC2D. ZM-008 can be used in B-cell lymphoma, glioma and prostate cancer research.
    ZM-008
  • HY-P991610
    S-095029
    		Inhibitor
    S-095029 is a humanized IgG1 monoclonal antibody inhibitor targeting NKG2A. S-095029 significantly attenuates Fc-effector functions, inhibits the interaction with its ligand HLA-E, and increases the antibody-dependent cellular cytotoxicity mediated by other Fc-competent mAbs. S-095029 has a potent antitumor activity with enhancement of killing activity and cytokine secretion (IFNγ, TNF-α and CXCL9) of NK and γδ T-cells in co-culture with cancer cells.
    S-095029
  • HY-N0434R
    Astragaloside III (Standard)
    		Activator
    Astragaloside III (Standard) is the analytical standard of Astragaloside III (HY-N0434). This product is intended for research and analytical applications. Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces TACE phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer.
    Astragaloside III (Standard)