2. Signaling Pathways
  3. Epigenetics
    TGF-beta/Smad
  4. PKC

PKC

Protein kinase C

PKC

Related Products

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PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of otherproteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC is involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory. These functions are achieved by PKC-mediated phosphorylation of other proteins.

PKC Isoform Specific Products:

PKC Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1595A
    CREBtide TFA
    		Substrate 98.72%
    CREBtide TFA is a CREB (cAMP response element binding protein)-like peptide. CREBtide TFA a synthetic 13 amino acid peptide, has been reported as a PKA and PKC substrate.
    CREBtide TFA
  • HY-RS11146
    Prkd1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Prkd1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkd1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkd1 Rat Pre-designed siRNA Set A
  • HY-P3784
    FKKSFKL-NH2
    FKKSFKL-NH2 is a protein kinase C-selective peptide. FKKSFKL-NH2 can be used for the research of various biochemical.
    FKKSFKL-NH2
  • HY-P3764
    Protein kinase C substrate
    Protein kinase C substrate is a substrate of Protein kinase C, can be used to detect protein. Protein kinase C is a key regulatory element in signal transduction and exerts its effects by catalysing specific substrate phosphorylation.
    Protein kinase C substrate
  • HY-112681B
    PKC-theta inhibitor 2 hydrochloride
    		Inhibitor
    PKC-theta inhibitor 2 hydrochloride is a potent and selective PKC-θ inhibitor with an IC50 value of 18 nM.
    PKC-theta inhibitor 2 hydrochloride
  • HY-RS11122
    PRKCD Human Pre-designed siRNA Set A
    		Inhibitor

    PRKCD Human Pre-designed siRNA Set A contains three designed siRNAs for PRKCD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PRKCD Human Pre-designed siRNA Set A
  • HY-P1088
    [Ser25] Protein Kinase C (19-31)
    [Ser25] Protein Kinase C (19-31) is a substrate of protein kinase C (PKC) (Km: 0.3 μM). [Ser25] Protein Kinase C (19-31) is derived from the pseudo-substrate regulatory domain of PKCα (19-31) with a Serine at position 25 replacing the wild-type Alanine.
    [Ser25] Protein Kinase C (19-31)
  • HY-RS11121
    Prkcb Rat Pre-designed siRNA Set A
    		Inhibitor

    Prkcb Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkcb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkcb Rat Pre-designed siRNA Set A
  • HY-118834
    Teleocidin A1
    		Activator
    Teleocidin A1 (Lyngbyatoxin A), a highly toxic skin irritant, is a potent activator of protein kinase C (PKC). Teleocidin A1 shows antiproliferative activity against HeLa cancer cells (IC50=9.2 nM).
    Teleocidin A1
  • HY-155619
    Protein kinase inhibitor 7
    		Inhibitor
    Protein kinase inhibitor 7 is an inhibitor for protein kinase A and protein kinase C. Protein kinase inhibitor 7 affects autocrine motility factor (AMF) signaling pathway, without affecting the cell motility.
    Protein kinase inhibitor 7
  • HY-W782599
    Senkyunolide B
    		Inhibitor
    Senkyunolide B is a phthalide found in Angelica sinensis. Senkyunolide B has broad antifungal activities. Senkyunolide B affects the spore germination and hyphae growth of Aspergillus fumigatus via down-regulating phosphatidylinositol-PKC-calcineurin axis and the expression of ENG genes.
    Senkyunolide B
  • HY-13502S
    Mitoxantrone-d8
    		Inhibitor
    Mitoxantrone-d8 (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM.
    Mitoxantrone-d<sub>8</sub>
  • HY-RS11129
    Prkcg Mouse Pre-designed siRNA Set A
    		Inhibitor

    Prkcg Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkcg gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkcg Mouse Pre-designed siRNA Set A
  • HY-RS11130
    Prkcg Rat Pre-designed siRNA Set A
    		Inhibitor

    Prkcg Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkcg gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkcg Rat Pre-designed siRNA Set A
  • HY-N12466
    3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine
    		Inhibitor
    3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 μM.
    3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine
  • HY-N0281R
    Daphnetin (Standard)
    		Inhibitor
    Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research.
    Daphnetin (Standard)
  • HY-156793
    hRIO2 kinase ligand-1
    		Ligand 99.95%
    hRIO2 kinase ligand-1 (compound 9) is a ligand of hRIO2 kinase, with a Kd value of 520 nM.
    hRIO2 kinase ligand-1
  • HY-P10471B
    Ala-MPSD
    Ala-MPSD is a control peptide for MPSD (HY-P10471). In Ala-MPSD, the four serine residues of MPSD are substituted by alanines.
    Ala-MPSD
  • HY-RS11118
    Prkca Rat Pre-designed siRNA Set A
    		Inhibitor

    Prkca Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkca gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkca Rat Pre-designed siRNA Set A
  • HY-P3816
    PKCε Inhibitor Scramble Peptide
    		Inhibitor
    PKCε Inhibitor Scramble Peptide is a scrambled peptide with identical amino acid composition to PKCε inhibitor peptide.
    PKCε Inhibitor Scramble Peptide
Cat. No. Product Name / Synonyms Application Reactivity
PKC Isoform Comparison

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