2. Signaling Pathways
  3. Epigenetics
    TGF-beta/Smad
  4. PKC
  5. PKC Modulator

PKC Modulator

PKC Isoform Comparison

PKC Modulators (6):

Cat. No. Product Name Effect Purity
  • HY-B0719
    Ingenol Mebutate
    		Modulator 99.65%
    Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.
  • HY-B1029
    Danazol
    		Modulator 99.70%
    Danazol inhibits the proliferation of cancer cell MDA-MB-231 and MCF-7 with IC50 of 65 µg/mL and 31 µg/mL. Danazol arrests the cell cycle at G1 phase, induces apoptosis in MDA-MB-231 through PKCα signaling pathway.
  • HY-159115
    ART26.12
    		Modulator 99.57%
    ART26.12 is a potent, selective and orally active inhibitor of FABP5. ART26.12 can regulate lipid metabolism and activate cannabinoid receptors. ART26.12 has analgesic effects and can be used in the research of diseases such as peripheral neuropathy and psoriasis.
  • HY-105231
    Bryostatin 1
    		Modulator 99.70%
    Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Kis of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties.
  • HY-B1029R
    Danazol (Standard)
    		Modulator
    Danazol standard inhibits the proliferation of cancer cell MDA-MB-231 and MCF-7 with IC50 of 65 µg/mL and 31 µg/mL. Danazol arrests the cell cycle at G1 phase, induces apoptosis in MDA-MB-231 through PKCα signaling pathway.
  • HY-B0719R
    Ingenol Mebutate (Standard)
    		Modulator
    Ingenol Mebutate (Standard) is the analytical standard of Ingenol Mebutate. This product is intended for research and analytical applications. Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.