2. Signaling Pathways
  3. Others
  4. Others

Others

 
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-115510
    SPR inhibitor 3
    		Inhibitor 99.84%
    SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels.
    SPR inhibitor 3
  • HY-137464A
    OATD-01
    		99.11%
    OATD-01 is a highly potent, first-in-class, orally active and selective chitinase inhibitor with low nanomolar activity toward CHIT1 (hCHIT1,IC50=23 nM). OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets. OATD-01 exhibits significant antifibrotic efficacy in vivo and can be used for pulmonary fibrosis (IPF) research.
    OATD-01
  • HY-150014
    AMT-NHS
    		98.55%
    AMT-NHS is an RNA-protein crosslinker. AMT-NHS is composed of a psoralen derivative and an N-hydroxysuccinimide ester group which react with RNA bases and primary amines of protein, respectively. AMT-NHS can penetrate into living yeast cells and crosslink Cbf5 to H/ACA snoRNAs with high specificity. AMT-NHS induces different crosslinking patterns and targets both single- and double-stranded regions of RNA. AMT-NHS can be used for capturing diverse RNA-protein interactions in cells.
    AMT-NHS
  • HY-147056
    PKRA83
    		98.04%
    PKRA83 (PKRA7) is a potent prokineticin (PK2) antagonist, which can compete for the binding of PK2 to its receptors PKR1 and PKR2. PKRA83 potently inhibits PK2 receptors, with IC50 values of 5.0 nM and 8.2 nM for PKR1 and PKR2, respectively. PKRA83 has anticancer, anti-arthritis and anti-angiogenic activities. PKRA83 can penetrate the blood-brain barrier.
    PKRA83
  • HY-139065
    AMPC
    		99.87%
    AMPC is a potent and effective TFF3 inhibitor. AMPC inhibits cell proliferation, survival, oncogenicity, and CSC-like behaviour in TFF3-positive CMS4 CRC cells. AMPC acts as a potential anti-cancer agent alone or in combination with 5-FU, and can be used for cancer research.
    AMPC
  • HY-109520
    Glatiramer acetate
    		≥98.0%
    Glatiramer acetate, a synthetic analogue of myelin basic protein and an immunomodulating agent, inhibits Experimental autoimmune encephalomyelitis (EAE), and can be used for the research of multiple sclerosis. Glatiramer acetate exhibits strong and promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type that migrate to the brain and lead to in situ bystander suppression.
    Glatiramer acetate
  • HY-14905
    Uridine triacetate
    		99.95%
    Uridine triacetate (Tri-O-acetyl uridine) is an orally active proagent of Uridine (HY-B1449). Uridine triacetate is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridine. Uridine triacetate is used for the research of 5-fluorouracil (5-FU) and capecitabine toxicity, or early-onset cardiac or central nervous system (CNS).
    Uridine triacetate
  • HY-N7698B
    Hexa-N-acetylchitohexaose
    		99.81%
    Hexa-N-acetylchitohexaose is an inducer of disease resistance in crop plants, which could elicit an increase of lignification-related and antioxidative enzymes in soybean plants. Hexa-N-acetylchitohexaose is a substrate of lysozyme. Hexa-N-acetylchitohexaose shows antitumor effect.
    Hexa-N-acetylchitohexaose
  • HY-107794
    Clodronate disodium tetrahydrate
    		99.86%
    Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain.
    Clodronate disodium tetrahydrate
  • HY-137978A
    Ezurpimtrostat hydrochloride
    		Inhibitor 99.29%
    Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases .
    Ezurpimtrostat hydrochloride
  • HY-15642
    TD-198946
    		99.93%
    TD-198946, a thienoindazole derivative, is a potent chondrogenic agent.
    TD-198946
  • HY-102081
    2OH-BNPP1
    		99.65%
    2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer.
    2OH-BNPP1
  • HY-W176171
    PU.1-IN-1
    		99.72%
    PU.1-IN-1 (compound A11) is a potent PU.1 inhibitor with an IC50 of 2 nM. PU.1-IN-1 has anti-inflammatory properties.
    PU.1-IN-1
  • HY-148226
    20-5,14-HEDGE
    		98.74%
    20-5,14-HEDGE is a 20-HETE analog. 20-5,14-HEDGE protects against lung ischemic reperfusion injury in rats.
    20-5,14-HEDGE
  • HY-111365
    TES-1025
    		Inhibitor 98.12%
    TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13 nM.
    TES-1025
  • HY-125145
    AA92593
    		98.60%
    AA92593 is a selective and competitive melanopsin OPN4 antagonist.
    AA92593
  • HY-148788
    Osivelotor
    		99.83%
    Osivelotor is an orally effective small molecule. Osivelotor is an allosteric regulator of deoxyhemoglobin S (HbS). Osivelotor increases the affinity of HbS to oxygen, inhibits HbS polymerization, and thus prevents erythrocyte sickling in the blood. Osivelotor can be used for research of sickle cell disease (SCD) .
    Osivelotor
  • HY-112902
    OGG1-IN-08
    		Inhibitor 99.60%
    OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1.
    OGG1-IN-08
  • HY-156483
    TT-012
    		99.89%
    TT-012 specifically binds to dynamic MITF and destroys the latter's dimer formation and DNA-binding ability. TT-012 inhibits the transcriptional activity of MITF in B16F10 melanoma cells. TT-012 inhibits the growth of high-MITF melanoma cells, and inhibits the tumor growth and metastasis with tolerable toxicity to liver and immune cells in animal models.
    TT-012
  • HY-102074
    ERDRP-0519
    		Inhibitor 99.90%
    ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency..
    ERDRP-0519
Cat. No. Product Name / Synonyms Application Reactivity