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Alendronate sodium  (Synonyms: Alendronic acid monosodium salt)

Cat. No.: HY-108685 Purity: 98.0%
COA
SDS
Handling Instructions Technical Support

Alendronate sodium is an orally active nitrogen-containing bisphosphonate. Alendronate sodium potently inhibits bone resorption. Alendronate sodium is used for the research of postmenopausal osteoporosis.

For research use only. We do not sell to patients.

Alendronate sodium

Alendronate sodium Chemical Structure

CAS No. : 129318-43-0

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Based on 10 publication(s) in Google Scholar

Other Forms of Alendronate sodium:

Alendronate sodium Related Antibodies

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Description

Alendronate sodium is an orally active nitrogen-containing bisphosphonate. Alendronate sodium potently inhibits bone resorption. Alendronate sodium is used for the research of postmenopausal osteoporosis[1].

Cellular Effect
Cell Line Type Value Description References
BMDM IC50
3.7 μM
Compound: Alen
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
[PMID: 31257875]
BMMC IC50
1.71 μM
Compound: Alendronate
Anti-osteoporosis activity in C57BL/6 mouse BMM cells assessed as inhibition of M-CSF/RANKL-induced osteoclastogenesis by measuring reduction in multinucleated TRAP+ cells incubated for 5 days with media replenishment for every 48 hrs measured by TRAP-sta
Anti-osteoporosis activity in C57BL/6 mouse BMM cells assessed as inhibition of M-CSF/RANKL-induced osteoclastogenesis by measuring reduction in multinucleated TRAP+ cells incubated for 5 days with media replenishment for every 48 hrs measured by TRAP-sta
[PMID: 33485256]
RAW264.7 IC50
0.084 μM
Compound: AS
Antiosteoclast activity in mouse RAW264.7 cells assessed as inhibition of RANKL-induced osteoclast differentiation after 5 days by TRAP assay
Antiosteoclast activity in mouse RAW264.7 cells assessed as inhibition of RANKL-induced osteoclast differentiation after 5 days by TRAP assay
10.1039/C5MD00482A
Clinical Trial
Molecular Weight

271.08

Formula

C4H12NNaO7P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(O)C(CCCN)(O)P(O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (92.22 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6889 mL 18.4447 mL 36.8895 mL
5 mM 0.7378 mL 3.6889 mL 7.3779 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.0%

SDS (393 KB)

COA (251 KB) HNMR (260 KB) CNMR (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.6889 mL 18.4447 mL 36.8895 mL 92.2237 mL
5 mM 0.7378 mL 3.6889 mL 7.3779 mL 18.4447 mL
10 mM 0.3689 mL 1.8445 mL 3.6889 mL 9.2224 mL
15 mM 0.2459 mL 1.2296 mL 2.4593 mL 6.1482 mL
20 mM 0.1844 mL 0.9222 mL 1.8445 mL 4.6112 mL
25 mM 0.1476 mL 0.7378 mL 1.4756 mL 3.6889 mL
30 mM 0.1230 mL 0.6148 mL 1.2296 mL 3.0741 mL
40 mM 0.0922 mL 0.4611 mL 0.9222 mL 2.3056 mL
50 mM 0.0738 mL 0.3689 mL 0.7378 mL 1.8445 mL
60 mM 0.0615 mL 0.3074 mL 0.6148 mL 1.5371 mL
80 mM 0.0461 mL 0.2306 mL 0.4611 mL 1.1528 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Alendronate sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alendronate129318-43-0Alendronic acid monosodiumOthersosteoporosisosteogenesisadipogenesisoralbisphosphonateInhibitorinhibitorinhibit

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