2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W013093
    Uridine triphosphate trisodium salt
    Uridine triphosphate (UTP) trisodium salt is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate trisodium salt activates membrane-bound P2Y2 receptors.
    Uridine triphosphate trisodium salt
  • HY-110385
    cGAMP disodium
    		98.47%
    cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
    cGAMP disodium
  • HY-125731
    Glycodeoxycholic Acid
    		99.08%
    Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis.
    Glycodeoxycholic Acid
  • HY-113407A
    D-Fructose-6-phosphate disodium
    		99.92%
    D-Fructose 6-phosphate disodium is an endogenous metabolite. D-Fructose 6-phosphate disodium can be obtained by hydrolysis of Fructose-1,6-bisphosphatase (FBPase). D-Fructose-6-phosphate disodium is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose-6-phosphate disodium can be used to detect glucosamine-6-phosphate synthase and TAL activities. D-Fructose 6-phosphate can be used to study Lewy body dementia.
    D-Fructose-6-phosphate disodium
  • HY-18733
    Lipoic acid
    		99.56%
    Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
    Lipoic acid
  • HY-B1811
    Vasopressin
    		99.83%
    Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.
    Vasopressin
  • HY-I0960
    Uracil
    		99.97%
    Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins.
    Uracil
  • HY-N0170
    Indole-3-carbinol
    		98.87%
    Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).
    Indole-3-carbinol
  • HY-N0144
    Piperine
    		98.73%
    Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL.
    Piperine
  • HY-113308A
    Taurolithocholic acid sodium salt
    		99.81%
    Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist.
    Taurolithocholic acid sodium salt
  • HY-N0697
    Crocin
    		99.68%
    Crocin (Crocin I) is an orally active natural product that can be isolated from the stigma of Crocus sativus. Crocin inhibits tumor cell proliferation and promotes apoptosis through JAK pathway. Crocin has anti-inflammatory, antioxidant and antitumor activities .
    Crocin
  • HY-14595
    Biochanin A
    		99.29%
    Biochanin A is a naturally occurring fatty acid amide hydrolase (FAAH) inhibitor, which inhibits FAAH with IC50s of 1.8, 1.4 and 2.4 μM for mouse, rat, and human FAAH, respectively.
    Biochanin A
  • HY-N0122
    5-Hydroxytryptophan
    		99.92%
    5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .
    5-Hydroxytryptophan
  • HY-W009362
    DL-Isocitric acid trisodium salt
    		≥98.0%
    DL-Isocitric acid trisodium salt is an endogenous metabolite. DL-Isocitric acid trisodium salt is an intermediate product in the citric acid cycle. DL-Isocitric acid trisodium salt can be used as a marker for determining the composition of isocitrates in fruit products.
    DL-Isocitric acid trisodium salt
  • HY-Y0271
    Urea
    		≥98.0%
    Urea is a powerful protein denaturant via both direct and indirect mechanisms. A potent emollient and keratolytic agent. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
    Urea
  • HY-113279
    7-Dehydrocholesterol
    		99.97%
    7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3.
    7-Dehydrocholesterol
  • HY-17427
    Emtricitabine
    		99.94%
    Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.
    Emtricitabine
  • HY-14781
    Levomefolic acid
    		98.55%
    Levomefolic acid (L-5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements.
    Levomefolic acid
  • HY-12956
    Dinoprost
    		99.63%
    Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour.
    Dinoprost
  • HY-B0964
    Riboflavin phosphate sodium
    Riboflavin phosphate sodium (FMN-Na) is a derivative of Riboflavin (vitamin B2) which is an essential nutrient for animals. Riboflavin phosphate sodium can be used for the research of progressive keratoconus, corneal ectasia and irregular astigmatism. Riboflavine phosphate sodium is a very effective NAD+-recycling agent.
    Riboflavin phosphate sodium
Cat. No. Product Name / Synonyms Application Reactivity