2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP

MMP

Matrix metalloproteinases

MMP

Related Products

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MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP Isoform Specific Products:

MMP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS08527
    Mmp13 Rat Pre-designed siRNA Set A
    		Inhibitor

    Mmp13 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp13 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp13 Rat Pre-designed siRNA Set A
    Mmp13 Rat Pre-designed siRNA Set A
  • HY-122106
    RS-104966
    		Inhibitor
    RS-104966 is a potent collagenase-1 (MMP-1) inhibitor. RS-104966 induces a conformational change in the side chains of the S10 pocket of MMP-1.
    RS-104966
  • HY-RS08519
    Mmp10 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mmp10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp10 Mouse Pre-designed siRNA Set A
    Mmp10 Mouse Pre-designed siRNA Set A
  • HY-162079
    Anticancer agent 183
    		Inhibitor
    Anticancer agent 183 (compound 4h) inhibits the matrix metalloproteinase-9 (MMP-9) viability than 75% at 100 μg/mL. Anticancer agent 183 has anticancer activity with an IC50 value of <0.14 μM on the A549 cell line. Anticancer agent 183 induces apoptotic.
    Anticancer agent 183
  • HY-114396
    BR351
    		Inhibitor
    BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively.
    BR351
  • HY-P5250
    Palmitoyl tripeptide-5
    		Inhibitor
    Palmitoyl tripeptide-5 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient.
    Palmitoyl tripeptide-5
  • HY-147936
    TP0556351
    		Inhibitor
    TP0556351 is a potent and selective matrix metalloproteinase-2 (MMP2) inhibitor with an IC50 value of 0.2 nM. TP0556351 reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model. TP0556351 can be used for researching idiopathic pulmonary fibrosis (IPF).
    TP0556351
  • HY-N12960
    Artobiloxanthone
    		Inhibitor
    Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). Artobiloxanthone inhibits Akt/mTOR pathway and STAT3 pathway, inhibits proliferation of SAS and T.Tn (with IC50 of 11 and 22 μM), and inhibits the cancer cell migration. Artobiloxanthone arrests cell cycle at S phase, and induces apoptosis in OSCC cells through activation of caspase 3/9.
    Artobiloxanthone
  • HY-B0261A
    Meloxicam sodium
    		Inhibitor
    Meloxicam sodium is a non-steroidal anti-inflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.
    Meloxicam sodium
  • HY-NP105
    Highly purified Type IX collagen, from bovine articular cartilage
    Highly purified Type IX collagen, from bovine articular cartilage (Bovine Type IX collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type IX collagen, from bovine articular cartilage
  • HY-149700
    ROCK2-IN-7
    ROCK2-IN-7 is a kinase inhibitor targeting to ROCK2. ROCK2-IN-7 inhibits ROCK2/pSTAT3 Signaling. ROCK2-IN-7 suppresses systemic immunity activation and attenuates inflammation in psoriasis model.
    ROCK2-IN-7
  • HY-168560
    MMP Inhibitor 4
    		Inhibitor
    MMP Inhibitor 4 (compound 4 B) is a potent MMP inhibitor. MMP Inhibitor 4 shows antiproliferative activity. MMP Inhibitor 4 induces cell cycle arrest at subG1 phase. MMP Inhibitor 4 decreases the mRNA expression of MMP2, MMP9 and VEGFA.
    MMP Inhibitor 4
  • HY-162453
    Anticancer agent 204
    		Inhibitor
    Anticancer agent 204 (Compound 6), a cinnamide fluorinated derivative, possesses anticancer activity. Anticancer agent 204 can arrest the cell cycle of HepG2 cells in the G1 phase and induce apoptosis by reducing the level of mitochondrial membrane polarization (MMP).
    Anticancer agent 204
  • HY-123736
    Ro 32-7315
    		Inhibitor
    Ro 32-7315 is a TNF-α converting enzyme (TACE) inhibitor.
    Ro 32-7315
  • HY-P991478
    RLVT-14-02
    		Inhibitor
    RLVT-14-02 is a human monoclonal antibody (mAb) targeting MMP14. RLVT-14-02 can be used in neuropathic pain research.
    RLVT-14-02
  • HY-172088
    Tubulin/MMP-IN-3
    		Inhibitor
    Tubulin/MMP-IN-3 (Compound 15j) is the dual inhibitor for tubulin polymerization and MMP, and inhibits MMP-2 and MMP-9 with IC50 of 21.13 μM and 19.24 μM. Tubulin/MMP-IN-3 inhibits NF-κB signaling pathway, causes mitochondrial dysfunction and the apoptosis through a mitochondrial-dependent pathway. Tubulin/MMP-IN-3 exhibits antiproliferative activity in a variety of cancer cells, arrests the cell cycle at G2/M phase, and exhibits antitumor efficacy in mouse models.
    Tubulin/MMP-IN-3
  • HY-P10174
    ADAM-17 Substrate
    ADAM-17 Substrate is a fluorescent substrate of ADAM.
    ADAM-17 Substrate
  • HY-171776
    OPB-3206
    		Inhibitor
    OPB-3206 is a selective matrix metalloproteinase (MMP) inhibitor. OPB-3206 inhibits interstitial collagenase, gelatinase A (MMP-2), gelatinase B (MMP-9) and stromelysin with IC50 values of 7×10-7 M, 5×10-6 M, 5×10-7 M and 2×10-6 M, respectively. OPB-3206 reversibly binds to the zinc-binding region of MMPs, preventing the activation of MMP-9 and reducing extracellular matrix degradation to inhibit tumor lung metastasis. OPB-3206 is promising for research of lung metastasis of osteosarcoma.
    OPB-3206
  • HY-NP130
    Highly purified Type II collagen, from goat articular cartilage
    Highly purified Type II collagen, from goat articular cartilage (Goat Type II collagen, immunization grade) is an immune grade collagen derived from goat articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type II collagen, from goat articular cartilage
  • HY-RS00272
    Adam17 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Adam17 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Adam17 Mouse Pre-designed siRNA Set A
    Adam17 Mouse Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
MMP Isoform Comparison

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