2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP

MMP

Matrix metalloproteinases

MMP

Related Products

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MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP Isoform Specific Products:

MMP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-NP103
    Highly purified Type III collagen, from bovine skin
    Highly purified Type III collagen, from bovine skin (Bovine Type III collagen, immunization grade) is an immune grade collagen derived from bovine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type III collagen, from bovine skin
  • HY-12093A
    (R)-MMP408
    		Inhibitor 99.91%
    (R)-MMP408 is an isomer of MMP408 (HY-12093). MMP408 is a potent and selective MMP-12 inhibitor that is derived from a potent matrix metalloprotease-2 and -13 inhibitor via lead optimization. MMP408 can block rhMMP-12-induced lung inflammation in vivo. MMP408 can be studied in research on COPD.
    (R)-MMP408
  • HY-P2166A
    MMP3 inhibitor 3 TFA
    		Inhibitor
    MMP3 inhibitor 3 (TFA) is an inhibitor of MMP3. MMP3 inhibitor 3 (TFA) can used to study breast cancer.
    MMP3 inhibitor 3 TFA
  • HY-RS00271
    ADAM17 Human Pre-designed siRNA Set A
    		Inhibitor

    ADAM17 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    ADAM17 Human Pre-designed siRNA Set A
  • HY-N1420R
    Rhamnose (Standard)
    		Inhibitor
    Amobam (Standard) is the analytical standard of Amobam. This product is intended for research and analytical applications. Amobam is a pesticidal.
    Rhamnose (Standard)
  • HY-NP109
    Highly purified type I collagen, from mouse skin
    		99%
    Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified type I collagen, from mouse skin
  • HY-RS08558
    Mmp9 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mmp9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp9 Mouse Pre-designed siRNA Set A
  • HY-RS08555
    Mmp8 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mmp8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp8 Mouse Pre-designed siRNA Set A
  • HY-RS08537
    MMP2 Human Pre-designed siRNA Set A
    		Inhibitor

    MMP2 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MMP2 Human Pre-designed siRNA Set A
  • HY-N0318R
    Salvianolic acid A (Standard)
    Salvianolic acid A (Standard) is the analytical standard of Salvianolic acid A. This product is intended for research and analytical applications. Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.
    Salvianolic acid A (Standard)
  • HY-13564A
    Batimastat sodium salt
    		Inhibitor 99.04%
    Batimastat sodium salt is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.
    Batimastat sodium salt
  • HY-111186
    Flocoumafen
    		99.17%
    Flocoumafen (WL 108366) is an orally active vitamin K epoxide reductase inhibitor and a multi-target ligand, which includes prostaglandin F synthase, serum albumin, glucocorticoid receptor 2, and MMP-9. Flocoumafen is a second-generation anticoagulant rodenticide (ARs) with a half-life of 177.4 hours and has deadly anticoagulant effects.
    Flocoumafen
  • HY-148124
    6-epi Doxycycline
    		Control 98.47%
    6-Epi-doxycycline is the C-6 epimer of Doxycycline (HY-N0565), formed as a degradation impurity through epimerization of Doxycycline under abnormal conditions (e.g., high temperature, pH changes, or humidity). 6-Epi-doxycycline is commonly used for the detection and analysis of impurity levels in pharmaceutical formulations.
    6-epi Doxycycline
  • HY-12170B
    (R)-Prinomastat
    		Control 98.36%
    (R)-Prinomastat ((R)-AG3340) is the R-isomer of Prinomastat (HY-12170) (a MMP Inhibitor).
    (R)-Prinomastat
  • HY-W745164
    3,3′-Bisdemethylpinoresinol
    		Inhibitor 98.96%
    3,3′-Bisdemethylpinoresinol, lignin, is a nature product and has MMP-1 inhibitory activity in UVA-irradiated human dermal fibroblasts. 3,3′-Bisdemethylpinoresinol can be isolated from the seeds of Morinda citrifolia.
    3,3′-Bisdemethylpinoresinol
  • HY-161169
    TP0628103
    		Inhibitor
    TP0628103 (compound 18) is a selective inhibitor of MMP-7, with the IC50 value of 0.17 nM that plays an important role in cancer and fibrosis.
    TP0628103
  • HY-157138
    MMP-9-IN-8
    MMP-9-IN-8 (Compound 3) is an MMP-9 inhibitor with inhibitory activities of 42.16% and 58.28% at 10 μM and 50 μM concentrations, respectively. MMP-9-IN-8 has anti-cancer activity and can induce apoptosis in MCF-7 cells with an IC50 value of 23.42 μM.
    MMP-9-IN-8
  • HY-NP126
    Highly purified Type XI collagen, from porcine articular cartilage
    Highly purified Type XI collagen, from porcine articular cartilage (Porcine Type XI collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type XI collagen, from porcine articular cartilage
  • HY-NP106
    Highly purified Type XI collagen, from bovine articular cartilage
    Highly purified Type XI collagen, from bovine articular cartilage (Bovine Type XI collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type XI collagen, from bovine articular cartilage
  • HY-NP108
    Highly purified type II collagen, from rat sternal cartilage
    Highly purified type II collagen, from rat sternal cartilage (Rat Type II collagen, immunization grade) is an immune grade collagen derived from rat sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified type II collagen, from rat sternal cartilage
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
MMP Isoform Comparison

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