2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP

MMP

Matrix metalloproteinases

MMP

Related Products

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MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP Isoform Specific Products:

MMP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1912
    Alpha 1(I) Collagen (614-639), human
    		98.63%
    Alpha 1(I) Collagen (614-639), human is a peptide fragment of alpha-1 type I collagen.
    Alpha 1(I) Collagen (614-639), human
  • HY-163129
    BPU
    		99.04%
    BPU arrests cell cycle progression in the sub-G1 phase. BPU is an anticancer agent through inhibiting blood vessel formation in tumor tissues.
    BPU
  • HY-P4373
    Hepcidin-1 (mouse)
    		Inducer
    Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation.
    Hepcidin-1 (mouse)
  • HY-14240
    PG 116800
    		Inhibitor 99.81%
    PG 116800 (PG 530742) is an orally avtive MMP inhibitor. PG 116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, while having substantially lower affinity for MMP-1 and -7. PG 116800 can be used for knee osteoarthritis research.
    PG 116800
  • HY-P10359A
    TAT-QFNP12 acetate
    		Inhibitor
    TAT-QFNP12 acetate is a peptide that blocks the NDRG2-PPM1A binding and reduces Smad2/3 phosphorylation, decreases astrocytic MMP-9 production and BBB disruption after subarachnoid hemorrhage (SAH).
    TAT-QFNP12 acetate
  • HY-P990251
    Anti-Human/Mouse denatured collagen type-I Antibody (XL313)
    Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to human/mouse denatured collagen type-I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) selectively binds to proteolyzed collagen type I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) reduces PD L1 levels in tumor cells. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) can be used for the researches of cancer and inflammation, such as such as ovarian tumor.
    Anti-Human/Mouse denatured collagen type-I Antibody (XL313)
  • HY-NP103
    Highly purified Type III collagen, from bovine skin
    Highly purified Type III collagen, from bovine skin (Bovine Type III collagen, immunization grade) is an immune grade collagen derived from bovine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type III collagen, from bovine skin
  • HY-12093A
    (R)-MMP408
    		Inhibitor 99.91%
    (R)-MMP408 is an isomer of MMP408 (HY-12093). MMP408 is a potent and selective MMP-12 inhibitor that is derived from a potent matrix metalloprotease-2 and -13 inhibitor via lead optimization. MMP408 can block rhMMP-12-induced lung inflammation in vivo. MMP408 can be studied in research on COPD.
    (R)-MMP408
  • HY-P2166A
    MMP3 inhibitor 3 TFA
    		Inhibitor
    MMP3 inhibitor 3 (TFA) is an inhibitor of MMP3. MMP3 inhibitor 3 (TFA) can used to study breast cancer.
    MMP3 inhibitor 3 TFA
  • HY-B0261S4
    Meloxicam-13C6
    		Inhibitor
    Meloxicam-13C6 is 13C6-labeled Meloxicam (HY-B0261). Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively.
    Meloxicam-<sup>13</sup>C<sub>6</sub>
  • HY-RS00271
    ADAM17 Human Pre-designed siRNA Set A
    		Inhibitor

    ADAM17 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    ADAM17 Human Pre-designed siRNA Set A
  • HY-NP109
    Highly purified type I collagen, from mouse skin
    		99%
    Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified type I collagen, from mouse skin
  • HY-N2503
    Ginsenoside F4
    		Inhibitor 98.54%
    Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis. Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues.
    Ginsenoside F4
  • HY-RS08558
    Mmp9 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mmp9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp9 Mouse Pre-designed siRNA Set A
  • HY-N0785R
    Ginkgolide C (Standard)
    		Activator
    Ginkgolide C (Standard) is the analytical standard of Ginkgolide C. This product is intended for research and analytical applications. Ginkgolide C is a flavone isolated from Ginkgo biloba leaves, possessing multiple biological functions, such as decreasing platelet aggregation and ameliorating Alzheimer disease.
    Ginkgolide C (Standard)
  • HY-RS08555
    Mmp8 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mmp8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp8 Mouse Pre-designed siRNA Set A
  • HY-RS08537
    MMP2 Human Pre-designed siRNA Set A
    		Inhibitor

    MMP2 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MMP2 Human Pre-designed siRNA Set A
  • HY-177590
    14-3-3-IN-2
    		Inhibitor 98.41%
    14-3-3-IN-2 is a 14-3-3 protein inhibitor with an IC50 of 15 nM. 14-3-3-IN-2 can disrupt the interaction of 14-3-3α with aminopeptidase N and down-regulate 14-3-3α increased MMP-1 mRNA levels.
    14-3-3-IN-2
  • HY-148124
    6-epi Doxycycline
    		Control 98.47%
    6-Epi-doxycycline is the C-6 epimer of Doxycycline (HY-N0565), formed as a degradation impurity through epimerization of Doxycycline under abnormal conditions (e.g., high temperature, pH changes, or humidity). 6-Epi-doxycycline is commonly used for the detection and analysis of impurity levels in pharmaceutical formulations.
    6-epi Doxycycline
  • HY-12170B
    (R)-Prinomastat
    		Control 98.36%
    (R)-Prinomastat ((R)-AG3340) is the R-isomer of Prinomastat (HY-12170) (a MMP Inhibitor).
    (R)-Prinomastat
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
MMP Isoform Comparison

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