2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N14443
    Haliangicin C
    		Inhibitor
    Haliangicin C has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
    Haliangicin C
  • HY-N14585
    Ramulosin
    		Inhibitor
    Ramulosin has an antifungal effect and inhibits the germination of fungal meristems.
    Ramulosin
  • HY-123096R
    Silthiofam (Standard)
    Silthiofam (Standard) is the analytical standard of Silthiofam. This product is intended for research and analytical applications. Silthiofam (Silthiopham) is a wheat fungicide used to control take-all disease caused by the soil-borne fungus Gaeumannomyces graminis.
    Silthiofam (Standard)
  • HY-173452
    DT-23
    		Inhibitor
    DT-23 is a potent antifungal agent with an MIC50 of 15 μg/mL. DT-23 inhibits recombinant Arg1 and Kcs1 with IC50s of 0.6 and 0.68 μM, respectively.
    DT-23
  • HY-N14995
    Frenolicin
    		Inhibitor
    Frenolicin is an antibiotic with antibacterial activity. Frenolicin also exhibits cytotoxicity against tumor cells.
    Frenolicin
  • HY-N15082
    Hypnophilin
    		Inhibitor
    Hypnophilin has a variety of activities, including anti-Gram-positive bacteria, negative bacteria, yeast, mold and tumor activities.
    Hypnophilin
  • HY-N14799
    Mycobacillin
    		Inhibitor
    Mycobacillin is a peptide antibiotic with anti-antifungal activity.
    Mycobacillin
  • HY-108547R
    Alexidine dihydrochloride (Standard)
    		Inhibitor
    Alexidine (dihydrochloride) (Standard) is the analytical standard of Alexidine (dihydrochloride). This product is intended for research and analytical applications. Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens.
    Alexidine dihydrochloride (Standard)
  • HY-N13906
    Alliacol B
    		Inhibitor
    Alliacol B is an antibiotic shows weak antibacterial and antifungal activity. Alliacol B inhibits DNA synthesis in cells of the ascitic form of Ehrlich carcinoma.
    Alliacol B
  • HY-N14729
    De-N-methylpamamycin-593A
    De-N-methylpamamycin-593A is a 16-membered ring macrocyclic dilactone. De-N-methylpamamycin-593A has Aerial Mycelium-inducing activity.
    De-N-methylpamamycin-593A
  • HY-B1838A
    Asulam potassium
    		Inhibitor
    Asulam (potassium salt) is a chitin synthase inhibitor against plant pathogenic fungi. Asulam (potassium salt) interferes with the biosynthesis of chitin in the fungal cell wall to destroy the integrity and normal growth and reproduction of fungal cells, thereby exerting bacteriostatic activity. Asulam (potassium salt) is promising for research of fungal diseases such as downy mildew and gray mold in spinach, tulips, daffodils and lilies.
    Asulam potassium
  • HY-157218
    PPm
    		Inhibitor
    PPm, a derivative of penthiopyrad and hapten, is a representative member of the succinate dehydrogenase inhibitors group of fungicides.
    PPm
  • HY-125152
    Candicidin D
    		Inhibitor
    Candicidin D (CndD) is an antibiotic, which exhibits antifungal activity through interaction with steroids in cell membranes. Candicidin D inhibits S. cerevisiae, Candida albicans and other Candida spp. with MIC of 0.25-1 μg/mL in RPMI-1640 medium.
    Candicidin D
  • HY-N15319
    Eupolauridine
    		Inhibitor
    Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC50 values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases.
    Eupolauridine
  • HY-109125
    SPK-843
    		Inhibitor
    SPK-843 is an antifungal agent. SPK-843 shows inhibitory activity against A. fumigatus MF-13, A. flavus TIMM 0057, and A. niger TIMM 2814 with MICs of 0.5 μg/mL, 0.25 μg/mL, and 0.0625 μg/mL, respectively. SPK-843 exhibits dose-dependent efficacy in murine models of pulmonary aspergillosis. SPK-843 can be used for the research of related fungal infections.
    SPK-843
  • HY-178196
    SDH-IN-32
    		Inhibitor
    SDH-IN-32 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 2.74 μM. SDH-IN-32 exhibits excellent antifungal activity. SDH-IN-32 can destroy the cell membrane structure and increase the permeability of the cell membrane. SDH-IN-32 can decrease the mitochondrial membrane potential (MMP), thereby inducing cell apoptosis and inhibiting the normal growth of mycelia. SDH-IN-32 can be used for the research of infection.
    SDH-IN-32
  • HY-W042181R
    N-Decyl-N,N-dimethyldecan-1-aminium chloride (Standard)
    		Inhibitor
    N-Decyl-N,N-dimethyldecan-1-aminium (chloride) (Standard) is the analytical standard of N-Decyl-N,N-dimethyldecan-1-aminium (chloride). This product is intended for research and analytical applications. N-Decyl-N,N-dimethyldecan-1-aminium chloride (Didecyldimethylammonium chloride) is a dialkyl-quaternary ammonium compound that is used in numerous products for its bactericidal, virucidal and fungicidal properties.
    N-Decyl-N,N-dimethyldecan-1-aminium chloride (Standard)
  • HY-N14557
    1,6-Dihydroxy-2-chlorophenazine
    		Inhibitor
    1,6-Dihydroxy-2-chlorophenazine has weak anti-fungal and anti-yeast activity.
    1,6-Dihydroxy-2-chlorophenazine
  • HY-N14020
    Glidobactin C
    		Inhibitor
    Glidobactin C (GlbC) is an anti-tumor antibiotic. Glidobactin C (GlbC) has the activity against pathogenic fungi and yeast. Glidobactin C has anti-Candida albicans and Aspergillus fumigatus activity with a MIC of 0.8 μg/mL. Glidobactin C also extends the survival of mice inoculated with leukemia P388 cells.
    Glidobactin C
  • HY-W018025R
    5,6-Dihydroxyindole (Standard)
    		Inhibitor
    5,6-Dihydroxyindole (Standard) is the analytical standard of 5,6-Dihydroxyindole. This product is intended for research and analytical applications. 5,6-Dihydroxyindole, a melanin precursor, has a broad-spectrum antibacterial, antifungal, antiviral, antiparasitic activity. 5,6-Dihydroxyindole has cytotoxic effects and is strongly toxic against various pathogens.
    5,6-Dihydroxyindole (Standard)
Cat. No. Product Name / Synonyms Application Reactivity