2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W093399S
    Ammonium bicarbonate-15N
    		Inhibitor
    Ammonium bicarbonate-15N is the 15N labeled isotope of Ammonium bicarbonate,AR,99% (HY-W093399). Ammonium bicarbonate,AR,99% is an analytical reagent-grade ammonium bicarbonate. Ammonium bicarbonate has antifungal activity. Ammonium bicarbonate is widely used in laboratory analysis, food processing, agricultural fertilization and other fields.
    Ammonium bicarbonate-<sup>15</sup>N
  • HY-N14212
    Polyoxin G
    		Inhibitor
    Polyoxin G is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
    Polyoxin G
  • HY-138035
    Tenellin
    Tenellin is a fungal metabolite that has been found in Beauveria. It inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocytes by 51, 57, and 74%, respectively, when used at a concentration of 200 μg/mL.1 Tenellin is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of- 4.84 and 11.95 μM, respectively.
    Tenellin
  • HY-N14737
    Dunaimycin A1
    		Inhibitor
    Dunaimycin A1 is a 24-membered macrolide compound with immunosuppressive activity and antifungal activity against Aspergillus niger. Dunaimycin A1 is promising for research of autoimmune diseases.
    Dunaimycin A1
  • HY-N14436
    Pradimicin Tl
    		Inhibitor
    Pradimicin T1 is an antibiotic. Pradimicin Tl has activity against filamentous fungi and yeast-like fungi.
    Pradimicin Tl
  • HY-N14604
    Chandrananimycin B
    		Inhibitor
    Chandrananimycin B has anti-mucor activity, as well as anti-tumor cell activity such as CCL HT29, MFXF 529L, MACL McF-7.
    Chandrananimycin B
  • HY-122448A
    (Rac)-Sativan
    		Inhibitor
    (Rac)-Sativan is an isoflavanoid with a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi. (Rac)-Sativan exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 µg/mL.
    (Rac)-Sativan
  • HY-139161R
    Penflufen (Standard)
    		Inhibitor
    Penflufen (Standard) is the analytical standard of Penflufen. This product is intended for research and analytical applications. Penflufen is a highly efficient, broad-spectrum succinate dehydrogenase inhibitor (SDHI). Penflufen can be used as a fungicide and has broad bioactivity against many fungal diseases, including potato black scurf, wheat sharp eyespot, rice sheath blight, and root rot in peanut and other similar fungal diseases.
    Penflufen (Standard)
  • HY-W104752
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol
    		Inhibitor 99.34%
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol (Compound 3n) is an antimicrobial and antioxidant agent, that inhibits Escherichia coli and Staphylococcus epidermidis, with MIC of 8 and 4 μg/mL. 5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol exhibits antioxidant activity with IC50 of 17.47 μM using DPPH free radical-scavenging method.
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol
  • HY-161813
    Antibacterial agent 229
    		Inhibitor
    Antibacterial agent 229 (compound 8a) is a potent antibacterial agent. Antibacterial agent 229 shows antibacterial and antifungal abilities. Antibacterial agent 229 disrupts the integrity of the bacterial membrane, intercalates into DNA. Antibacterial agent 229 inhibits topoisomerase IV with an IC50 value of 10.88 µM.
    Antibacterial agent 229
  • HY-W741557
    Griseofulvic Acid
    		Inhibitor
    Griseofulvic acid is a metabolite of the antifungal Griseofulvin (HY-17583). It induces protein aggregation and tubulin polymerization in cell-free assays.
    Griseofulvic Acid
  • HY-W780198
    Endophenazine A
    Endophenazine A has activity against Gram-positive bacteria and filamentous fungi such as mucor and Penicillium. Its weeding ability to Lemna minor is relatively low.
    Endophenazine A
  • HY-111222
    PD 113270
    		Inhibitor
    PD 113270 (CL 1565-B) is an antitumor agent. PD 113270 exhibits inhibitory effects to yeasts.
    PD 113270
  • HY-N14552
    Quadrilineatin
    		Inhibitor
    Quadrilineatin has antifungal and bacterial effects.
    Quadrilineatin
  • HY-173283
    Antifungal agent 129
    		Inhibitor
    Antifungal agent 129 (Compound 4g) is an inhibitor targeting Rhizoctonia solani, with an EC50 value of 4.27 mg/L. It has a good control effect against rice sheath blight in in vitro and in vivo experiments. Preliminary exploration through scanning electron microscopy, molecular docking, enzyme activity determination, and cytotoxicity experiments has revealed that Antifungal agent 129 may exert its inhibitory activity by affecting the cell structure or physiological processes of Rhizoctonia solani. Antifungal agent 129 can be used in the research of plant diseases in the agricultural field, such as rice sheath blight, which are caused by Rhizoctonia solani.
    Antifungal agent 129
  • HY-N1347R
    Robinetin (Standard)
    		Inhibitor
    Robinetin (Standard) is the analytical standard of Robinetin. This product is intended for research and analytical applications. Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation.
    Robinetin (Standard)
  • HY-174388
    Antifungal agent 134
    		Inhibitor
    Antifungal agent 134 (Compound B13) is an antifungal agent with EC50s of 3.24, 1.89, 1.70, 0.36, 4.27, and 1.50 μg/mL for Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia solani, Colletotrichum orbiculare, and Alternaria alternata, respectively. Antifungal agent 134 can disrupt the cell membrane and mitochondria of the hyphae, leading to significant ROS accumulation. Antifungal agent 134 also has significant herbicidal activities against field weeds, such as Amaranthus retroflexus L and Abutilon theophrasti Medicus. Antifungal agent 134 can be used for crop diseases and field weeds research.
    Antifungal agent 134
  • HY-N14191
    Malonylniphimycin
    		Inhibitor
    Malonylniphimycin is a macrolide antibiotic found in Streptomyces str. hygroscopicus B-7. Malonylniphimycin is resistant to Gram-positive bacteria, fungi and yeasts.
    Malonylniphimycin
  • HY-N1422R
    Hecogenin (Standard)
    		Inhibitor
    Hecogenin (Standard) is the analytical standard of Hecogenin. This product is intended for research and analytical applications. Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects.
    Hecogenin (Standard)
  • HY-W010549R
    2-Methylcyclohexanone (Standard)
    3-tert-Butyl-4-methoxyphenol (Standard) is the analytical standard of 3-tert-Butyl-4-methoxyphenol. This product is intended for research and analytical applications. 3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system.
    2-Methylcyclohexanone (Standard)
Cat. No. Product Name / Synonyms Application Reactivity